Disease relevance of LRIG2

• A double blind clinical study demonstrated an approximately 2.0- and 1.6-fold increase in average percentage improvement in healing of the lesions in patients suffering from HSV-1 and HSV-2 diseases, respectively, when treated with LIG-2 compared with PIG-2 [1].
• A comparative double blind clinical pilot study of optimized LIG-2 gel was carried out for eight weeks and compared with PIG-2 on 20 Herpes simplex patients (10 patients each for HSV-1 and HSV-2, divided into two groups each of 5 patients) [1].

High impact information on LRIG2

• We have searched for additional members of the human LRIG family and identified LRIG2 () [2].
• N-glycosidase F treatment resulted in a reduction of the apparent molecular weight to 107 kDa, showing that LRIG2 was a glycoprotein carrying N-linked oligosaccharides [2].
• The LRIG2 gene was localized to chromosome 1p13 and had an open reading frame of 1065 amino acids [2].
• Immunoblotting of COS-7 cell lysates demonstrated that heterologously expressed human LRIG2 had an apparent molecular weight of 132 kDa under reducing gel-running conditions [2].
• Cell surface biotinylation experiments and confocal fluorescence laser microscopy demonstrated expression of LRIG2 both at the cell surface and in the cytoplasm [2].

Biological context of LRIG2

• In conclusion, LRIG2 was found to be a glycoprotein which was encoded by a gene on human chromosome 1p13 and its mRNA was present in all tissues analyzed [2].

Associations of LRIG2 with chemical compounds

• The LRIG2 protein was predicted to have the same domain organization as LRIG1 with a signal peptide, an extracellular part containing15 leucine-rich repeats and three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail [2].

Other interactions of LRIG2

• Approximately 2.2- and 2.5-fold increase in skin drug retention in LIG-1 and LIG-2, respectively, was determined [1].

Analytical, diagnostic and therapeutic context of LRIG2

• LRIG2 was detected in tissue lysates from stomach, prostate, lung, and fetal brain by immunoblotting [2].
• Northern blotting and RT-PCR revealed LRIG2 transcripts in all tissues analyzed [2].
• We obtained the highest sensitivity in PCR using our Lig1/Lig2 primers with a detection of 6 leptospires [3].

References