Disease relevance of Tchh

• Unique distribution of trichohyalin was detected in psoriasis [1].
• Further, trichohyalin was also detected in scattered granular cells of a number of hyperplastic skin diseases [2].

High impact information on Tchh

• The human hornerin gene was mapped between trichohyalin and filaggrin on chromosome 1q21.3, the region being completely syntenic with the counterpart of the mouse [3].
• Trichohyalin mechanically strengthens the hair follicle: multiple cross-bridging roles in the inner root shealth [4].
• Together, our new data document that trichohyalin is a multi-functional cross-bridging protein that functions in the inner root sheath and perhaps in other specialized epithelial tissues by conferring to and coordinating mechanical strength between their peripheral cell envelope barrier structures and their cytoplasmic keratin filament networks [4].
• The expression level of the very arginine-rich skin protein trichohyalin was not affected in transgenic mice [5].
• Treatment of CBA mice with AHF increased the graft survival and inhibited antibody formation to sheep erythrocytes [6].

Biological context of Tchh

• Cytochemistry of trichohyalin granules: a possible role for cornification of inner root sheath cell in the hair follicle [7].

Anatomical context of Tchh

• BACKGROUND: Recently, in the filiform papillae epithelium of mouse dorsal tongue, we showed the presence of hybrid granules in which filaggrin and trichohyalin were both present, but physically segregated [2].
• The low-molecular-weight polypeptide factors were obtained from bovine thymus (TF), pineal gland (PF) and anterior hypothalamus (AHF) [6].

Analytical, diagnostic and therapeutic context of Tchh

• Here we examine the effect of CTSL deficiency on hair follicle development and cycling in ctsl(-/-) mice by light and electron microscopy, Ki67/terminal dUTP nick-end labeling, and trichohyalin immunofluorescence [8].

References