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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sperm Agglutination

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Disease relevance of Sperm Agglutination


High impact information on Sperm Agglutination

  • There was no correlation between the reaction of sera with FA-1 and the titers obtained through the sperm agglutination technique and the sperm immobilization technique [2].
  • The present report demonstrates the identity between the glycoprotein antigens recognized by the human H6-3C4 monoclonal antibody (mAb) and the murine S19 mAb, generated in our laboratory to sperm agglutination antigen-1 (SAGA-1) [3].
  • Sperm agglutination antigen-1 (SAGA-1) is a human male reproductive tract glycoform of CD52 [4].
  • Taken together, the data presented here demonstrated that mAb A36 cognate sperm surface antigen, encoded by SA-36 cDNA, is a GPI/NLK-like protein involved in sperm agglutination [5].
  • However, the promoting effects of these reagents were blocked when spermatozoa were pretreated with a cell-permeable Ca(2+) chelator (BAPTA-AM, 25 microM), whereas the same pretreatment with a cell-impermeable Ca(2+) chelator (BAPTA, 25 microM) had almost no influence on sperm agglutination [6].

Anatomical context of Sperm Agglutination


Associations of Sperm Agglutination with chemical compounds


Gene context of Sperm Agglutination

  • Seminal TF antigen levels correlated significantly with sperm agglutination (p = 0.03) and abnormal sperm morphology (p = 0.04) [14].
  • Addition of porcine serum albumin (PSA, 1-4 mg mL(-1)) or methyl-beta-cyclodextrin (MBC, 5-10 mg mL(-1)) instead of BSA was as effective as BSA (4 mg mL(-1)) in enhancing sperm agglutination [15].
  • In 204 patients, antisperm antibodies were also measured by serum sperm-agglutination tests: The results showed a highly significant correlation with the results of MAR testing [16].
  • A calmodulin antagonist (W-7, 2 microM), that potentially blocks the stimulator of the calcium/calmodulin-dependent phosphodiesterases, significantly enhanced the effect of bicarbonate on sperm agglutination [17].
  • The H6-3C4 S19 cognate antigen, designated Sperm Agglutination Antigen-1 (SAGA-1), was characterized as a polymorphic, highly acidic, GPI-anchored glycoprotein on the surface of human spermatozoa [18].


  1. Methylprednisolone treatment of immunologic infertility in male. Shulman, J.F., Shulman, S. Fertil. Steril. (1982) [Pubmed]
  2. Involvement of fertilization antigen (FA-1) in involuntary immunoinfertility in humans. Naz, R.K. J. Clin. Invest. (1987) [Pubmed]
  3. N-linked glycan of a sperm CD52 glycoform associated with human infertility. Diekman, A.B., Norton, E.J., Klotz, K.L., Westbrook, V.A., Shibahara, H., Naaby-Hansen, S., Flickinger, C.J., Herr, J.C. FASEB J. (1999) [Pubmed]
  4. Analysis of a human sperm CD52 glycoform in primates: identification of an animal model for immunocontraceptive vaccine development. McCauley, T.C., Kurth, B.E., Norton, E.J., Klotz, K.L., Westbrook, V.A., Rao, A.J., Herr, J.C., Diekman, A.B. Biol. Reprod. (2002) [Pubmed]
  5. Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination. Yakirevich, E., Naot, Y. Biol. Reprod. (2000) [Pubmed]
  6. Involvement of cytoplasmic free calcium in boar sperm: head-to-head agglutination induced by a cell-permeable cyclic adenosine monophosphate analog. Harayama, H., Okada, K., Miyake, M. J. Androl. (2003) [Pubmed]
  7. IgG-coated latex particles and the identification of sperm antibodies. Grobler, S., Franken, D.R., Pretorius, E. S. Afr. Med. J. (1984) [Pubmed]
  8. Sperm immunofluorescence in infertile men: Its relationship with sperm agglutination and gel agglutination. Jequier, A.M., Crich, J.P. Arch. Androl. (1980) [Pubmed]
  9. Antisperm antibodies in the polyglandular autoimmune (PGA) syndrome type I: response to cyclical steroid therapy. Tsatsoulis, A., Shalet, S.M. Clin. Endocrinol. (Oxf) (1991) [Pubmed]
  10. Histone-mediated agglutination of epididymal spermatozoa and the occurrence of histone receptors on the rat sperm surface. Majumder, G.C. J. Reprod. Fertil. (1981) [Pubmed]
  11. Antigenic cross-reactivity of human tracheal mucin with human sperm and trophoblasts correlates with the expression of mucin 8 gene messenger ribonucleic acid in reproductive tract tissues. D'Cruz, O.J., Dunn, T.S., Pichan, P., Hass, G.G., Sachdev, G.P. Fertil. Steril. (1996) [Pubmed]
  12. Treatment of infertility caused by antisperm antibodies. Kremer, J., Jager, S., Kuiken, J. Int. J. Fertil. (1978) [Pubmed]
  13. Semen analysis in an infertile man with seminal vesicles cysts associated with ipsilateral renal agenesis. Andrade-Rocha, F.T. International urology and nephrology. (2006) [Pubmed]
  14. Seminal tissue factor revisited. Lwaleed, B., Jackson, C., Greenfield, R., Stewart, A., Delves, G., Birch, B., Cooper, A. Int. J. Androl. (2006) [Pubmed]
  15. Role of cyclic adenosine 3',5'-monophosphate and serum albumin in head-to-head agglutination of boar spermatozoa. Harayama, H., Miyake, M., Kato, S. Reprod. Fertil. Dev. (2000) [Pubmed]
  16. The value of the mixed antiglobulin reaction (MAR test) as an addition to routine seminal analysis in the evaluation of the subfertile couple. Stedronska, J., Hendry, W.F. American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction. (1983) [Pubmed]
  17. Relationship between bicarbonate and cyclic nucleotide in the promoting effects on head-to-head agglutination in boar spermatozoa. Harayama, H., Kato, S. Asian J. Androl. (2002) [Pubmed]
  18. Anti-sperm antibodies from infertile patients and their cognate sperm antigens: a review. Identity between SAGA-1, the H6-3C4 antigen, and CD52. Diekman, A.B., Norton, E.J., Westbrook, V.A., Klotz, K.L., Naaby-Hansen, S., Herr, J.C. Am. J. Reprod. Immunol. (2000) [Pubmed]
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