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MeSH Review:

Pneumonia, Progressive Interstitial, of Sheep

Woodall, C.J. et al., Salvatori, D. et al., Davies, J.M. et al., Quérat, G. et al., Legastelois, I. et al., et al.

Villet, Faure, Bouzar, Morin, Verdier, Chebloune, Legras,

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Disease relevance of Pneumonia, Progressive Interstitial, of Sheep

Ovine and caprine lentiviruses share the capacity to induce slowly progressive and inflammatory diseases of the central nervous system (leukoencephalitis or visna), lungs (progressive pneumonia or maedi), and joints (arthritis) in their natural hosts [1].
Lack of trans-activation function for Maedi Visna virus and Caprine arthritis encephalitis virus Tat proteins [2].
Synthesized compounds, along with other purine nucleoside analogues previously synthesized in our laboratory, have been tested for their antiviral activity against Bovine herpesvirus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV), the latter being an in vitro and in vivo model of Human Immunodeficiency Virus (HIV) [3].
The retroviruses reviewed include the oncovirus, bovine leukosis virus, and the lentiviruses, equine infectious anemia virus; maedi/visna virus, caprine arthritis-encephalitis virus and bovine visna-like virus [4].

High impact information on Pneumonia, Progressive Interstitial, of Sheep

The alpha chemokine interleukin-8 (IL-8) was detected in cell free bronchoalveolar lavage fluid from naturally infected animals, confirmed by RT-PCR, presenting typical lesions of maedi and elevated total alveolar cell counts [5].
The relative levels of selected cytokine, interleukin-2 receptor, class II DR and DQ RNAs, and maedi visna virus (MVV) RNA were measured by reverse-transcriptase polymerase chain reaction (RT-PCR) in the lungs of sheep with natural maedi visna virus infection (n = 8) and a group of age/sex/breed-matched MVV seronegative sheep (n = 4) [6].
Weise and Carnegie (1988) found a region of sequence similarity between the pol gene of the Maedi Visna virus (MVV), which induces demyelinating encephalitis in sheep, and myelin basic protein (MBP), which is known to induce experimental allergic encephalitis (EAE) in laboratory animals [7].
Experimental maedi virus infection in sheep: early cellular and humoral immune response following parenteral inoculation [8].

References

Highly lytic and persistent lentiviruses naturally present in sheep with progressive pneumonia are genetically distinct. Quérat, G., Barban, V., Sauze, N., Filippi, P., Vigne, R., Russo, P., Vitu, C. J. Virol. (1984) [Pubmed]
Lack of trans-activation function for Maedi Visna virus and Caprine arthritis encephalitis virus Tat proteins. Villet, S., Faure, C., Bouzar, B.A., Morin, T., Verdier, G., Chebloune, Y., Legras, C. Virology (2003) [Pubmed]
Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1. Salvatori, D., Volpini, R., Vincenzetti, S., Vita, A., Costanzi, S., Lambertucci, C., Cristalli, G., Vittori, S. Bioorg. Med. Chem. (2002) [Pubmed]
Comparative features of retroviral infections of livestock. Evermann, J.F. Comp. Immunol. Microbiol. Infect. Dis. (1990) [Pubmed]
Alveolar macrophages from sheep naturally infected by visna-maedi virus contribute to IL-8 production in the lung. Legastelois, I., Cottin, V., Mornex, J.F., Cordier, G. Vet. Immunol. Immunopathol. (1997) [Pubmed]
Differential levels of mRNAs for cytokines, the interleukin-2 receptor and class II DR/DQ genes in ovine interstitial pneumonia induced by maedi visna virus infection. Woodall, C.J., Maclaren, L.J., Watt, N.J. Vet. Pathol. (1997) [Pubmed]
Mimicry of a 21.5 kDa myelin basic protein peptide by a Maedi Visna virus polymerase peptide does not contribute to the pathogenesis of encephalitis in sheep. Davies, J.M., Watt, N.J., Torsteinsdottir, S., Carnegie, P.R. Vet. Immunol. Immunopathol. (1996) [Pubmed]
Experimental maedi virus infection in sheep: early cellular and humoral immune response following parenteral inoculation. Larsen, H.J., Hyllseth, B., Krogsrud, J. Am. J. Vet. Res. (1982) [Pubmed]

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