Disease relevance of Hydatidiform Mole, Invasive

• Structural differences found in the asparagine-linked sugar chains of human chorionic gonadotropins purified from the urine of patients with invasive mole and with choriocarcinoma [1].
• Paper electrophoresis of the oligosaccharide fraction obtained by hydrazinolysis of human chorionic gonadotropin (HCG), which was purified from the urine of two patients with invasive mole, gave fractionation patterns different from those of normal and hydatidiform mole HCGs [1].

High impact information on Hydatidiform Mole, Invasive

• In contrast, no alpha 2M was detected in invasive moles or choriocarcinomas [2].
• Similarly, NEP in hydatidiform mole and invasive mole was localized on the membrane of syncytiotrophoblasts, but not on hyperplastic cytotrophoblasts [3].
• METHODS AND RESULTS: The immunohistochemical expression of p57kip2 protein was investigated using paraffin-embedded tissue sections in histologically unequivocal cases of CHM (n = 51), PHM (n = 7), invasive mole (n = 1), and hydropic miscarriage (n = 2), as well as in histologically undetermined cases (n = 9) [4].
• The present study was undertaken to evaluate the efficacy of using steroid hormone antagonists tamoxifen and Ru486 for chemotherapy or chemoprevention of choriocarcinoma or other less malignant gestational trophoblastic diseases (GTDs) such as invasive mole [5].
• Tumours with a histological diagnosis of invasive moles and choriocarcinoma showed very strong binding of EGFR [6].

Chemical compound and disease context of Hydatidiform Mole, Invasive

• Complete remission was achieved in 84.9% of cases of invasive mole and in 59.3% of cases of choriocarcinoma when 5-fluorouracil was used as the initial treatment [7].
• However, the incidence of invasive mole in the bestatin group (2/25, 8%) was significantly lower than that of the non-bestatin group (7/24, 29.2%) [8].
• The present report describes our experience with serious complications of a vincristine overdose in an 18-year-old female who had methotrexate-resistant invasive mole [9].
• This study was performed to determine whether bestatin (Ubenimex) has clinical prophylactic effects on the onset of invasive mole and a direct inhibitory effect on the growth of hydatidiform molar cells [8].

Biological context of Hydatidiform Mole, Invasive

• Relaxin was identified in the syncytiotrophoblast of normal placenta at all stages of gestation and also, for the first time, in hydatidiform mole, invasive mole, and choriocarcinoma [10].

Gene context of Hydatidiform Mole, Invasive

• But hMSH2 expression in the invasive moles (36.5%, 4 out of 11) was weaker than that in complete hydatidiform moles (P = 0.044) [11].
• 7. These same components were also observed in the sera of patients with hydatidform mole and invasive mole [12].
• 3. Localization and activities of Al-p, HSAP, Ac-p, and LDH in invasive mole are closely similar to those in H. mole [13].
• Experience gained in the management of 24 patients with choriocarcinoma and invasive mole admitted to Groote Schuur Hospital, Cape Town, during the past 10 years is analysed [14].
• Tumors with histological diagnosis of invasive moles and choriocarcinoma showed very strong binding of EGF and thus EGF has the potential of identifying high risk lesions [15].

Analytical, diagnostic and therapeutic context of Hydatidiform Mole, Invasive

• Prolactin was found by immunoperoxidase technique in the syncytiotrophoblast of normal placenta throughout gestation, and also in hydatidiform mole, invasive mole and choriocarcinoma [16].

References