Disease relevance of Erythromelalgia

• The patient described herein had 3 features known to be associated with secondary erythermalgia: 1) onset during pregnancy, 2) hypertension, and 3) verapamil treatment (6) [1].
• The generation of thrombin appears not to be essential for the formation of these platelet thrombi, thereby giving a plausible explanation for the inefficacy of coumadin derivatives and heparin in the prevention and treatment of erythromelalgia in essential thrombocythemia [2].
• Treatment of erythromelalgia with aspirin resulted in disappearance of erythromelalgic signs and symptoms, which was paralleled by a significant decrease of beta-TG and TM levels [2].
• There were eight early syndromes (four neurotoxic, two gastrointestinal, two allergic); three late syndromes (hepatotoxic, accelerated nephrotoxic, erythromelalgia); and three delayed syndromes (delayed nephrotoxic, delayed neurotoxic, rhabdomyolysis) [3].
• Within 10 d after withdrawal of aspirin, three patients developed arterial microvascular thrombosis of extremities (erythromelalgia), which was preceded by a 3-30-fold increase in urinary thromboxane excretion as compared with patients who remained asymptomatic [4].

High impact information on Erythromelalgia

• Treatment of erythromelalgia with propranolol [5].
• Nifedipine and erythromelalgia [6].
• Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7 [7].
• The symptoms of adults with erythromelalgia are markedly relieved after treatment with a single daily dose of acetylsalicylic acid [8].
• Based on previous experience with parenteral prostanoids, we studied the effect of misoprostol treatment, an orally administered prostaglandin E1 analog, in patients with erythromelalgia [9].

Chemical compound and disease context of Erythromelalgia

• This study demonstrates that misoprostol is clinically superior to placebo in patients with erythromelalgia [9].
• Coumadin failed to improve platelet survival or symptoms caused by erythromelalgia [10].
• The increased in vivo thromboxane A2 generation existing in these patients and the selective sensitivity of erythromelalgia to aspirin suggest that platelet PGG/H synthase products may be involved in transducing the increased thrombotic risk [11].
• Successful treatment of erythromelalgia with sodium nitroprusside [12].
• Serotonin reuptake inhibitors, Raynaud's phenomenon and erythromelalgia [13].

Anatomical context of Erythromelalgia

• Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons [14].

Gene context of Erythromelalgia

• As compared with asymptomatic ET patients and control subjects erythromelalgia was characterized by significantly higher beta-TG and TM levels but no significant differences were detected in either F1 + 2 or TDP levels [2].
• Secondary erythermalgia in systemic lupus erythematosus; comment] [15].
• Presence of specific IgG antibody to the A type inclusions of erythromelalgia-related poxvirus in the sera of patients with epidemic erythromelalgia [16].
• Autonomic neurodermatology (Part I): Erythromelalgia, reflex sympathetic dystrophy, and livedo reticularis [17].
• Thus, cyclooxygenase metabolites are necessary for erythromelalgia to develop [18].

References