High impact information on Spatial Behavior

• Rats with cytotoxic N-methyl-D-aspartate (NMDA) RS lesions or surgical CG transection were tested on two spatial tasks in the Morris water task; a place learning task, sensitive to nonspatial and spatial behavior, and a matching-to-place task, sensitive to spatial behavior [1].
• Dissociation of the effect of spatial behaviors on the phosphorylation of cAMP-response element binding protein (CREB) within the nucleus accumbens [2].
• This work shows that glutamate receptors in both NAC subregions are important for spatial behavior [3].
• Accuracy of spatial behavior was highly correlated to percentage ChAT depletion (r = 0.75) [4].
• The authors investigated the effects on spatial behavior of coadministrations of a benzodiazepine, chlordiazepoxide (CDP), with a noncompetitive N-methyl-d-aspartate receptor antagonist (NMDAR), dizocilpine (DZP), and a muscarinic cholinergic receptor antagonist, scopolamine (SCP) [5].

Anatomical context of Spatial Behavior

• Retrograde tracing methods were used to identify forebrain projections to NCL and to suggest a possible role of this area in mediating spatial behavior [6].
• To better define the role of the avian caudolateral neostriatum (NCL) in spatial behavior, we used homing pigeons to explore the effects of NCL lesions on a sun compass based spatial learning task [7].

Associations of Spatial Behavior with chemical compounds

• In addition, these results also suggest that the lateral septum may play a possible role in some form of spatial behavior easily disrupted by atropine methylnitrate [8].
• Chronic exposure to caffeine during early development modifies spatial behavior in juvenile jewel fish schools [9].
• In a first experiment, diazepam (0.25 mg/kg) improves the performance of subordinate mice toward the female, as shown by the increase of proxemic behavior, anogenital sniffing, and social grooming of the female [10].
• These findings suggest sex-specific patterns of relationships between circulating testosterone and spatial processing, which apply to everyday spatial behavior [11].

Gene context of Spatial Behavior

• The LPC-1 and LPC-2 are likely to correspond to the processes represented by P3a and P3b, based on their temporal and spatial behavior [12].
• NCL is therefore suited to participate in a neural circuit that regulates spatial behavior [6].
• Thus, we show that RS cortex is part of an extended neural circuit involved in spatial behavior in both Long-Evans and Dark Agouti rats, but its role in the place task may be masked by an innate nonspatial deficit in Dark Agouti rats [13].

References