Disease relevance of Maximal Expiratory Flow Rate

• CONCLUSION: MIFR are less sensitive than MEFR to detect airway obstruction in COPD patients [1].

High impact information on Maximal Expiratory Flow Rate

• Leukotriene D was, on average, 5,900 times more potent than histamine on a molar basis in producing an identical decrement in maximal expiratory flow rate at 30% of control vital capacity above residual volume [2].
• All animals were injected with capsaicin (16 micrograms/kg iv), and changes in respiratory compliance and maximal expiratory flow rate were used as indicators of bronchoconstriction [3].
• Compared to placebo, no deterioration in pulmonary function occurred with pindolol and in three tests--maximum voluntary ventilation (MVV) (L/min), MVV%, midexpiratory flow rate (MEFR) (L/min)--significant improvement occurred [4].
• While propranolol produced slight deterioration in pulmonary function, pindolol and chlorthalidone produced slight but significant improvement (p less than 0.05) with maximum MEFR (L/sec) [4].
• FEV1, FVC, and MEFR decreased during the day in two crab processors, and precipitins were evident in sera from nine, but findings were normal in the fish packers [5].

Biological context of Maximal Expiratory Flow Rate

• FVC, FEV1.0, MEFR and sGaw increased significantly after inhalation of fenoterol in both asthmatic patients and healthy subjects [6].
• Increases in maximal expiratory flow rate induced by atropine and glycopyrrolate were significant at one-half hour, while atropine alone induced a significant increase in one second forced expiratory volume [7].

Associations of Maximal Expiratory Flow Rate with chemical compounds

• The anti-pyretic effect of MEFR was comparable to that of paracetamol (150 mg/kg body wt., p.o.), a standard anti-pyretic agent [8].
• We have measured in 16 healthy volunteers (mean +/- SD age, 23.7 +/- 1.6 yr) specific airway conductance (SGaw), maximal inspiratory (MIFR) and expiratory (MEFR) flow rates before and 15, 35, and 45 min after extensive upper airway anesthesia (UAA) with 10% lidocaine [9].
• At the 1-, 3-, 6- and 15-minute intervals the response to the isoproterenol dose was significantly greater than the response to the SCH 1000 dose for FEV1, FVC and MEFR [10].

Gene context of Maximal Expiratory Flow Rate

• Pulmonary function tests (ERV, IC, VC, MVV FEV1% and MEFR) were studied on one hundred and sixty six subjects of either sex, age group ranging from 17 years to 25 years [11].

References