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Chemical Compound Review

Berotec     5-[1-hydroxy-2-[1-(4- hydroxyphenyl)propan...

Synonyms: Berotek, fenoterol, Phenoterol, Fenoterolum, Partusisten, ...
 
 
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Disease relevance of Phenoterol

 

Psychiatry related information on Phenoterol

  • Time trends in fenoterol and asthma deaths: optical illusion or reality check [6]?
  • Bronchodilatation was evaluated by measuring serial peak expiratory flow rates (PEFR) for eight hours after inhaled fenoterol and calculating the area under the time-response curves and the percentage increment from the baseline values [7].
 

High impact information on Phenoterol

 

Chemical compound and disease context of Phenoterol

 

Biological context of Phenoterol

  • Both groups showed significant improvement on forced expiratory volume in one second (FEV1), maximum expiratory flow at 25% and 50% vital capacity but those who received fenoterol therapy showed more significant bronchodilation after one hour [17].
  • In both situations the bronchodilating effect of fenoterol as measured by changes in forced expiratory volume in 1 sec, peak expiratory flow, and maximal expiratory flow at 50% vital capacity was significant (p less than 0.01) compared to placebo [18].
  • From these observations we suggest that low-dose fenoterol protects against bronchoconstriction induced by exercise, a naturally occurring stimulus reflecting airway hyperresponsiveness [19].
  • At clinic attendances, the patients had a significantly higher mean PEFR after 4 wk on terbutaline (385 L/min) than after fenoterol (316 L/min) (p less than 0.001) [20].
  • In the 15 min following the fenoterol spray the increase in the average nasal airway resistance (NAR) was significantly higher than the increase in NAR after placebo (p = 0.026), suggesting that fenoterol may also act as a vasodilator in the nose [21].
 

Anatomical context of Phenoterol

 

Associations of Phenoterol with other chemical compounds

 

Gene context of Phenoterol

 

Analytical, diagnostic and therapeutic context of Phenoterol

References

  1. Diurnal expiratory flow after inhalation of Freons and fenoterol in childhood asthma. Graff-Lonnevig, V. J. Allergy Clin. Immunol. (1979) [Pubmed]
  2. Fenoterol dose-response study in children with asthma. Feldman, C.H., Sher, T.H., Hutchinson, V.E., Feldman, B.R., Davis, W.J. J. Allergy Clin. Immunol. (1984) [Pubmed]
  3. Inhibition of the immediate allergic reaction in the nose by the beta-2 adrenostimulant fenoterol. Borum, P., Mygind, N. J. Allergy Clin. Immunol. (1980) [Pubmed]
  4. Comparative dose-response study of three anticholinergic agents and fenoterol using a metered dose inhaler in patients with chronic obstructive pulmonary disease. Ikeda, A., Nishimura, K., Koyama, H., Izumi, T. Thorax (1995) [Pubmed]
  5. Fenoterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Heel, R.C., Brogden, R.N., Speight, T.M., Avery, G.S. Drugs (1978) [Pubmed]
  6. Time trends in fenoterol and asthma deaths: optical illusion or reality check? Pearce, N., Crane, J., Beasley, R. Journal of clinical epidemiology. (1998) [Pubmed]
  7. Oral sustained-release aminophylline and bronchodilator response to inhaled fenoterol in patients with chronic airflow obstruction. Carpentiere, G., Marino, S., Castello, F., Zarcone, P., Cipolla, G., Baldanza, C. Chest (1985) [Pubmed]
  8. The use of beta-agonists and the risk of death and near death from asthma. Spitzer, W.O., Suissa, S., Ernst, P., Horwitz, R.I., Habbick, B., Cockcroft, D., Boivin, J.F., McNutt, M., Buist, A.S., Rebuck, A.S. N. Engl. J. Med. (1992) [Pubmed]
  9. Effect of fenoterol on bromine-containing oxidants from eosinophils. Green, W.F., Rimmer, S.J. Lancet (1993) [Pubmed]
  10. Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma. Wong, C.S., Pavord, I.D., Williams, J., Britton, J.R., Tattersfield, A.E. Lancet (1990) [Pubmed]
  11. Hypokalaemia induced by inhalation of fenoterol. Haalboom, J.R., Deenstra, M., Struyvenberg, A. Lancet (1985) [Pubmed]
  12. Effects of ipratropium bromide and fenoterol aerosols in pulmonary emphysema. Hughes, J.A., Tobin, M.J., Bellamy, D., Hutchison, D.C. Thorax (1982) [Pubmed]
  13. Cardiovascular safety of high doses of inhaled fenoterol and albuterol in acute severe asthma. Newhouse, M.T., Chapman, K.R., McCallum, A.L., Abboud, R.T., Bowie, D.M., Hodder, R.V., Paré, P.D., Mesic-Fuchs, H., Molfino, N.A. Chest (1996) [Pubmed]
  14. beta-agonistic bronchodilators: comparison of dose/response in working rat hearts. Zimmer, G., Dahinten, A., Fitzner, A., Halbig, S., Noll, T., Treusch, F., Libertus, H. Chest (2000) [Pubmed]
  15. The treatment of threatened premature labor by betamimetic drugs: a comparison of fenoterol and ritodrine. Richter, R., Hinselmann, M.J. Obstetrics and gynecology. (1979) [Pubmed]
  16. Effect of fenoterol (Th1165a) infusion on uterine and umbilical blood flow in pregnant sheep. Ehrenkranz, R.A., Walker, A.M., Oakes, G.K., Hamilton, L.A., Chez, R.A. Am. J. Obstet. Gynecol. (1977) [Pubmed]
  17. Nebulized isoetharine and fenoterol in acute attacks of asthma. König, P., Hurst, D.J. Arch. Intern. Med. (1983) [Pubmed]
  18. Intranasal fenoterol in asthmatic subjects: an alternative route of administration. Groth, S., Dirksen, H., Mygind, N. J. Allergy Clin. Immunol. (1984) [Pubmed]
  19. The protective effect of low-dose inhaled fenoterol against methacholine and exercise-induced bronchoconstriction in asthma: a dose-response study. Magnussen, H., Rabe, K.F. J. Allergy Clin. Immunol. (1992) [Pubmed]
  20. Comparison of four weeks' treatment with fenoterol and terbutaline aerosols in adult asthmatics. A double-blind crossover study. Trembath, P.W., Greenacre, J.K., Anderson, M., Dimmock, S., Mansfield, L., Wadsworth, J., Green, M. J. Allergy Clin. Immunol. (1979) [Pubmed]
  21. Effect of a beta-adrenergic agonist, fenoterol, on nasal sensitivity to allergen. Schumacher, M.J. J. Allergy Clin. Immunol. (1980) [Pubmed]
  22. Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization. Seybold, J., Newton, R., Wright, L., Finney, P.A., Suttorp, N., Barnes, P.J., Adcock, I.M., Giembycz, M.A. J. Biol. Chem. (1998) [Pubmed]
  23. Up-regulation of airway smooth muscle histamine H(1) receptor mRNA, protein, and function by beta(2)-adrenoceptor activation. Mak, J.C., Roffel, A.F., Katsunuma, T., Elzinga, C.R., Zaagsma, J., Barnes, P.J. Mol. Pharmacol. (2000) [Pubmed]
  24. Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling. Frambach, T., Müller, T., Freund, S., Engelhardt, S., Sütterlin, M., Lohse, M.J., Dietl, J. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  25. Kinetic analysis of agonist-induced down-regulation of the beta(2)-adrenergic receptor in BEAS-2B cells reveals high- and low-affinity components. Williams, B.R., Barber, R., Clark, R.B. Mol. Pharmacol. (2000) [Pubmed]
  26. Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats. Ryall, J.G., Plant, D.R., Gregorevic, P., Sillence, M.N., Lynch, G.S. J. Physiol. (Lond.) (2004) [Pubmed]
  27. Comparison of ipratropium solution, fenoterol solution, and their combination administered by nebulizer and face mask to children with acute asthma. Watson, W.T., Becker, A.B., Simons, F.E. J. Allergy Clin. Immunol. (1988) [Pubmed]
  28. Beta-agonists: what is the evidence that their use increases the risk of asthma morbidity and mortality? Beasley, R., Pearce, N., Crane, J., Burgess, C. J. Allergy Clin. Immunol. (1999) [Pubmed]
  29. Desensitization of beta2-adrenoceptor and hypersensitization to phosphodiesterase inhibitors elicited by beta2-agonists in guinea pig eosinophils. Mio, M., Kirino, Y., Kamei, C. J. Allergy Clin. Immunol. (2000) [Pubmed]
  30. Beta-adrenergic agonists and bronchial hyperreactivity: role of beta2-adrenergic and tachykinin neurokinin-2 receptors. Katsunuma, T., Fujita, K., Mak, J.C., Barnes, P.J., Ueno, K., Iikura, Y. J. Allergy Clin. Immunol. (2000) [Pubmed]
  31. Fenoterol but not dobutamine increases erythropoietin production in humans. Gleiter, C.H., Becker, T., Schreeb, K.H., Freudenthaler, S., Gundert-Remy, U. Clin. Pharmacol. Ther. (1997) [Pubmed]
  32. beta2-Adrenoceptor agonist modulates endothelin-1 receptors in human isolated bronchi. Faisy, C., Pinto, F., Danel, C., Naline, E., Risse, P.A., Leroy, I., Israel-Biet, D., Fagon, J.Y., Candenas, M.L., Advenier, C. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  33. Exposure to TARC alters beta2-adrenergic receptor signaling in human peripheral blood T lymphocytes. Heijink, I.H., Vellenga, E., Oostendorp, J., de Monchy, J.G., Postma, D.S., Kauffman, H.F. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  34. Role of cyclic AMP in the modulation of IgE production by the beta 2-adrenoceptor agonist, fenoterol. Coqueret, O., Demarquay, D., Lagente, V. Eur. Respir. J. (1996) [Pubmed]
  35. Prescribed fenoterol and death from asthma in New Zealand, 1981-83: case-control study. Crane, J., Pearce, N., Flatt, A., Burgess, C., Jackson, R., Kwong, T., Ball, M., Beasley, R. Lancet (1989) [Pubmed]
  36. End of the New Zealand asthma mortality epidemic. Pearce, N., Beasley, R., Crane, J., Burgess, C., Jackson, R. Lancet (1995) [Pubmed]
  37. Aerosol fenoterol by intermittent positive pressure breathing in asthmatic patients. Ruffin, R.E., Montgomery, J.M., Newhouse, M.T. Clin. Pharmacol. Ther. (1979) [Pubmed]
 
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