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MeSH Review:

Leishmaniasis, Diffuse Cutaneous

Ulrich, M. et al., Ritter, U. et al., Akuffo, H. et al., Cabrera, M. et al., Convit, J. et al., et al.

Convit, Ulrich, Polegre, Avila, Rodríguez, Mazzedo, Blanco,

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Disease relevance of Leishmaniasis, Diffuse Cutaneous

We recently demonstrated that monocyte chemotactic protein-1 (MCP-1) is strongly expressed in lesions of patients with self-healing localized cutaneous leishmaniasis (LCL) whereas it is scarce in those of chronic diffuse cutaneous leishmaniasis (DCL) [1].
Leishmania-specific IgG4 antibodies predominated in 19/20 sera from patients with diffuse cutaneous leishmaniasis, and IgG1 antibodies predominated in 9/10 cases of untreated visceral leishmaniasis [2].
Soluble CD23 was increased in the four patient groups (0.001<P<0.05) compared by the Mann-Whitney test to healthy subjects, particularly in mucocutaneous leishmaniasis (MCL) and diffuse cutaneous leishmaniasis (DCL) patients [3].
Diabetes mellitus associated with pentamidine isethionate in diffuse cutaneous leishmaniasis [4].

High impact information on Leishmaniasis, Diffuse Cutaneous

Treatment of diffuse cutaneous leishmaniasis with chlorpromazine ointment [5].
In contrast, stimulation of the same cells with promastigotes derived from patients with the persistent, disseminated form of the disease (diffuse cutaneous leishmaniasis; DCL) stimulated the expression of IL-10 rather than IFN-gamma [6].
Traditionally, the mainstay of visceral and diffuse cutaneous leishmaniasis therapy has been pentavalent antimony, with pentamidine and amphotericin B reserved for refractory cases [7].
The efficacy of pentamidine combined with allopurinol and immunotherapy for the treatment of patients with diffuse cutaneous leishmaniasis [8].
Aminosidine and its combination with sodium stibogluconate in the treatment of diffuse cutaneous leishmaniasis caused by Leishmania aethiopica [9].

Chemical compound and disease context of Leishmaniasis, Diffuse Cutaneous

Therapy of Venezuelan patients with severe mucocutaneous or early lesions of diffuse cutaneous leishmaniasis with a vaccine containing pasteurized Leishmania promastigotes and bacillus Calmette-Guerin: preliminary report [10].

Gene context of Leishmaniasis, Diffuse Cutaneous

High serum-soluble interleukin-2 receptor is not associated with the immunosuppression in diffuse cutaneous leishmaniasis [11].

Analytical, diagnostic and therapeutic context of Leishmaniasis, Diffuse Cutaneous

The use of pairs of enriched polyclonal sera from mucocutaneous and diffuse cutaneous leishmaniasis permits the preliminary classification of isolates in the L. mexicana or L. braziliensis complexes by a simple, inexpensive, and quantitative immunoassay [12].

References

Monocyte chemotactic protein-1 stimulates the killing of leishmania major by human monocytes, acts synergistically with IFN-gamma and is antagonized by IL-4. Ritter, U., Moll, H. Eur. J. Immunol. (2000) [Pubmed]
Differing antibody IgG isotypes in the polar forms of leprosy and cutaneous leishmaniasis characterized by antigen-specific T cell anergy. Ulrich, M., Rodriguez, V., Centeno, M., Convit, J. Clin. Exp. Immunol. (1995) [Pubmed]
Variations in the serum levels of soluble CD23, nitric oxide and IgE across the spectrum of American cutaneous leishmaniasis. Cabrera, M., Rodriguez, O., Monsalve, I., Tovar, R., Hagel, I. Acta Trop. (2003) [Pubmed]
Diabetes mellitus associated with pentamidine isethionate in diffuse cutaneous leishmaniasis. Costa, J.M., Moraes, M.S., Saldanha, A.C., Barral, A., Burattini, M.N. Rev. Soc. Bras. Med. Trop. (1995) [Pubmed]
Treatment of diffuse cutaneous leishmaniasis with chlorpromazine ointment. Henriksen, T.H., Lende, S. Lancet (1983) [Pubmed]
Leishmania aethiopica derived from diffuse leishmaniasis patients preferentially induce mRNA for interleukin-10 while those from localized leishmaniasis patients induce interferon-gamma. Akuffo, H., Maasho, K., Blostedt, M., Höjeberg, B., Britton, S., Bakhiet, M. J. Infect. Dis. (1997) [Pubmed]
The role of interferon-gamma in the treatment of visceral and diffuse cutaneous leishmaniasis. Badaro, R., Johnson, W.D. J. Infect. Dis. (1993) [Pubmed]
The efficacy of pentamidine combined with allopurinol and immunotherapy for the treatment of patients with diffuse cutaneous leishmaniasis. Becker, I., Volkow, P., Velasco-Castrejon, O., Salaiza-Suazo, N., Berzunza-Cruz, M., Dominguez, J.S., Morales-Vargas, A., Ruiz-Remigio, A., Perez-Montfort, R. Parasitol. Res. (1999) [Pubmed]
Aminosidine and its combination with sodium stibogluconate in the treatment of diffuse cutaneous leishmaniasis caused by Leishmania aethiopica. Teklemariam, S., Hiwot, A.G., Frommel, D., Miko, T.L., Ganlov, G., Bryceson, A. Trans. R. Soc. Trop. Med. Hyg. (1994) [Pubmed]
Therapy of Venezuelan patients with severe mucocutaneous or early lesions of diffuse cutaneous leishmaniasis with a vaccine containing pasteurized Leishmania promastigotes and bacillus Calmette-Guerin: preliminary report. Convit, J., Ulrich, M., Polegre, M.A., Avila, A., Rodríguez, N., Mazzedo, M.I., Blanco, B. Mem. Inst. Oswaldo Cruz (2004) [Pubmed]
High serum-soluble interleukin-2 receptor is not associated with the immunosuppression in diffuse cutaneous leishmaniasis. Akuffo, H., Maasho, K. Scand. J. Immunol. (1994) [Pubmed]
Serological patterns and specificity in American cutaneous leishmaniasis. Ulrich, M., Centeno, M., Mattout, Z., Convit, J. Am. J. Trop. Med. Hyg. (1988) [Pubmed]

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