Disease relevance of Compulsive Behavior

• Dopamine agonists have been implicated in causing compulsive behaviors in patients with Parkinson's disease (PD) [1].
• Complex tics, stereotypies, and compulsive behavior as clinical presentation of a juvenile progressive dystonia suggestive of Hallervorden-Spatz disease [2].
• The occurrence of abnormal movements or perserverative/compulsive behaviors was noted in 34 (76%) of a group of 45 hyperactive boys during a double-blind crossover treatment trial of methylphenidate and dextroamphetamine given in a wide range of doses [3].
• Both of these patients were treated with fluoxetine for psychopharmacologic management of obsessive features in the form of food preoccupation and hyperphagia or for compulsive behaviors in the form of severe self-injurious behaviors [4].

Psychiatry related information on Compulsive Behavior

• Dextroamphetamine tended to produce more compulsive behaviors, which were also more likely to resemble clinical obsessive-compulsive disorder (OCD), than did methylphenidate [3].
• Manganese madness was the term used to describe the initial psychiatric syndrome (compulsive behavior, emotional lability, hallucinations) [5].

High impact information on Compulsive Behavior

• CONCLUSION: Fluoxetine was associated with a statistically significant reduction in OCD severity, including time engaged in obsessional and/or compulsive behaviors [6].
• Cocaine-induced foraging may represent a drug-induced model of a type of compulsive behavior [7].
• Group differences in CSF CRF were unrelated to current clinical ratings of depression, anxiety, tics, and obsessive compulsive behaviors [8].
• No increases were observed in obsessions or compulsive behaviors as assessed with the Yale-Brown Obsessive Compulsive Challenge Scale, neither in the pentagastrin, nor in the placebo condition [9].
• Bupropion and compulsive behavior [10].

Chemical compound and disease context of Compulsive Behavior

• Abnormal movements and compulsive behaviors tended to co-occur on methylphenidate only; no general "Tourette-OCD diathesis" was found for this population [3].
• We conclude that the 5-HT(2C) receptor null mutant mouse provides a promising model of compulsive behavior and a means to further explore the role of 5-HT in OCD [11].
• CONCLUSIONS: The present results replicated the animal findings about reduction in compulsive behavior after nicotine administration [12].
• Treatment of crack-cocaine-induced compulsive behavior with trazodone [13].
• A trial with donepezil led to significant amelioration of the compulsive behavior without adverse motor effects [14].

Gene context of Compulsive Behavior

• Obsessive compulsive behaviors in the patient was positively correlated with presence of attention deficit hyperactivity disorder and self-injurious behaviors [15].
• These genes are deleted in individuals with TI deletion and are implicated in compulsive behavior and lower intellectual ability in individuals with TI versus TII [16].
• Obsessive-compulsive disorder is a worldwide psychiatric disorder with a lifetime prevalence of 2% and mainly characterized by obsessional ideas and compulsive behaviors and rituals [17].

References