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Chemical Compound Review

DIVALPROEX SODIUM     sodium; 2-propylpentanoate; 2...

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Disease relevance of VALPROIC ACID


Psychiatry related information on VALPROIC ACID


High impact information on VALPROIC ACID


Chemical compound and disease context of VALPROIC ACID


Biological context of VALPROIC ACID

  • With Theo-Dur Sprinkle the bioavailability was reduced to 44%, and the absorption profiles became unpredictable with marked interindividual variations [20].
  • METHODS: The effect of concomitant administration of divalproex sodium on the pharmacokinetics of amitriptyline and its active metabolite, nortriptyline, was investigated in an open-label, sequential, two-period phase I study [21].
  • CONCLUSIONS: Divalproex was not significantly more effective than monitoring without drug for the prevention of postpartum episodes of bipolar disorder [22].
  • SETTING: Eight headache/neurology clinics throughout the United States. PATIENTS: One hundred seven patients randomized to divalproex or placebo (2:1 ratio): 70 receiving divalproex and 37 receiving placebo [23].
  • Divalproex decreased marijuana craving during abstinence, yet increased ratings of 'anxious', 'irritable', 'bad effect', and 'tired.' Divalproex worsened performance on psychomotor tasks, and increased food intake regardless of marijuana condition [24].

Anatomical context of VALPROIC ACID


Associations of VALPROIC ACID with other chemical compounds

  • This study assessed presynaptic dopamine function in neuroleptic- and mood-stabilizer-naive nonpsychotic first-episode manic patients before and after treatment with divalproex sodium by measuring [(18)F]6-fluoro-L-dopa ([(18)F]DOPA) uptake in the striatum with positron emission tomography (PET) [30].
  • The bioavailability and absorption pattern of theophylline from Theo-Dur Sprinkle were investigated in adults both in fasting conditions and after two different meals [31].
  • The authors designed a 21-day prospective, double-blind, randomized, placebo-controlled pilot study of divalproex sodium as add-on treatment to haloperidol in 12 hospitalized patients with acute exacerbations of chronic schizophrenia [32].
  • Effects of divalproex sodium on 5-HT1A receptor function in healthy human males: hypothermic, hormonal, and behavioral responses to ipsapirone [33].
  • To examine the effects of divalproex sodium (DVP) on 5-HT1A receptor function in humans, we measured the hypothermic, adrenocorticotropic hormone (ACTH) cortisol, and behavioral responses to ipsapirone in 10 healthy male volunteers [33].

Gene context of VALPROIC ACID

  • CYP2C19 induction by ginkgo could be a plausible explanation for the subtherapeutic levels of Dilantin and Depakote [34].
  • The following agents were used ACTH (n = 14), prednisone (n = 12), IV IgG (n = 6), immuran (n = 2), depakote (n = 1), and inderal (n = 1) [35].
  • Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium [11].
  • This study demonstrates the efficacy of divalproex sodium as monotherapy for the treatment of partial-onset seizures and supports its role as one of the first-line antiepileptic drug treatments for patients with partial epilepsy [36].
  • BACKGROUND: The aim of this study was to evaluate the efficacy of divalproex (VLP) to prevent episode recurrence in postpartum women with bipolar disorder [22].

Analytical, diagnostic and therapeutic context of VALPROIC ACID


  1. Olanzapine versus divalproex in the treatment of acute mania. Tohen, M., Baker, R.W., Altshuler, L.L., Zarate, C.A., Suppes, T., Ketter, T.A., Milton, D.R., Risser, R., Gilmore, J.A., Breier, A., Tollefson, G.A. The American journal of psychiatry. (2002) [Pubmed]
  2. Anticonvulsant hypersensitivity syndrome from addition of lamotrigine to divalproex. Rahman, M., Haider, N. The American journal of psychiatry. (2005) [Pubmed]
  3. Successful treatment of persistent migraine aura with divalproex sodium. Rothrock, J.F. Neurology (1997) [Pubmed]
  4. The effect of hemodialysis and hemoperfusion on serum valproic acid concentration. Kandrotas, R.J., Love, J.M., Gal, P., Oles, K.S. Neurology (1990) [Pubmed]
  5. A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors. Glantz, M.J., Cole, B.F., Friedberg, M.H., Lathi, E., Choy, H., Furie, K., Akerley, W., Wahlberg, L., Lekos, A., Louis, S. Neurology (1996) [Pubmed]
  6. A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group. Bowden, C.L., Calabrese, J.R., McElroy, S.L., Gyulai, L., Wassef, A., Petty, F., Pope, H.G., Chou, J.C., Keck, P.E., Rhodes, L.J., Swann, A.C., Hirschfeld, R.M., Wozniak, P.J. Arch. Gen. Psychiatry (2000) [Pubmed]
  7. Relation of serum valproate concentration to response in mania. Bowden, C.L., Janicak, P.G., Orsulak, P., Swann, A.C., Davis, J.M., Calabrese, J.R., Goodnick, P., Small, J.G., Rush, A.J., Kimmel, S.E., Risch, S.C., Morris, D.D. The American journal of psychiatry. (1996) [Pubmed]
  8. Impact of trait impulsivity and state aggression on divalproex versus placebo response in borderline personality disorder. Hollander, E., Swann, A.C., Coccaro, E.F., Jiang, P., Smith, T.B. The American journal of psychiatry. (2005) [Pubmed]
  9. Differential effect of number of previous episodes of affective disorder on response to lithium or divalproex in acute mania. Swann, A.C., Bowden, C.L., Calabrese, J.R., Dilsaver, S.C., Morris, D.D. The American journal of psychiatry. (1999) [Pubmed]
  10. Pilot comparison of extended-release and standard preparations of divalproex sodium in patients with bipolar and schizoaffective disorders. Centorrino, F., Kelleher, J.P., Berry, J.M., Salvatore, P., Eakin, M., Fogarty, K.V., Fellman, V., Baldessarini, R.J. The American journal of psychiatry. (2003) [Pubmed]
  11. Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium. Scheffer, R.E., Kowatch, R.A., Carmody, T., Rush, A.J. The American journal of psychiatry. (2005) [Pubmed]
  12. A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorder. Calabrese, J.R., Shelton, M.D., Rapport, D.J., Youngstrom, E.A., Jackson, K., Bilali, S., Ganocy, S.J., Findling, R.L. The American journal of psychiatry. (2005) [Pubmed]
  13. Lower effectiveness of divalproex versus valproic acid in a prospective, quasi-experimental clinical trial involving 9,260 psychiatric admissions. Wassef, A.A., Winkler, D.E., Roache, A.L., Abobo, V.B., Lopez, L.M., Averill, J.P., Mian, A.I., Overall, J.E. The American journal of psychiatry. (2005) [Pubmed]
  14. Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47-week study. Tohen, M., Ketter, T.A., Zarate, C.A., Suppes, T., Frye, M., Altshuler, L., Zajecka, J., Schuh, L.M., Risser, R.C., Brown, E., Baker, R.W. The American journal of psychiatry. (2003) [Pubmed]
  15. U.S. experience with valproate in manic depressive illness: a multicenter trial. Brown, R. The Journal of clinical psychiatry. (1989) [Pubmed]
  16. A comparison of divalproex with propranolol and placebo for the prophylaxis of migraine without aura. Kaniecki, R.G. Arch. Neurol. (1997) [Pubmed]
  17. Generalized edema with risperidone: divalproex sodium treatment. Baldassano, C.F., Ghaemi, S.N. The Journal of clinical psychiatry. (1996) [Pubmed]
  18. Divalproex sodium in headache: literature review and clinical guidelines. Silberstein, S.D. Headache. (1996) [Pubmed]
  19. Cost-effectiveness of antiepileptic drugs in migraine prophylaxis. Adelman, J.U., Adelman, L.C., Von Seggern, R. Headache. (2002) [Pubmed]
  20. Effects of food on the absorption of theophylline in children. Pedersen, S. J. Allergy Clin. Immunol. (1986) [Pubmed]
  21. Effects of divalproex sodium on amitriptyline and nortriptyline pharmacokinetics. Wong, S.L., Cavanaugh, J., Shi, H., Awni, W.M., Granneman, G.R. Clin. Pharmacol. Ther. (1996) [Pubmed]
  22. Prevention of postpartum episodes in women with bipolar disorder. Wisner, K.L., Hanusa, B.H., Peindl, K.S., Perel, J.M. Biol. Psychiatry (2004) [Pubmed]
  23. Migraine prophylaxis with divalproex. Mathew, N.T., Saper, J.R., Silberstein, S.D., Rankin, L., Markley, H.G., Solomon, S., Rapoport, A.M., Silber, C.J., Deaton, R.L. Arch. Neurol. (1995) [Pubmed]
  24. Marijuana withdrawal in humans: effects of oral THC or divalproex. Haney, M., Hart, C.L., Vosburg, S.K., Nasser, J., Bennett, A., Zubaran, C., Foltin, R.W. Neuropsychopharmacology (2004) [Pubmed]
  25. Effect of divalproex-lamotrigine combination therapy in frontal lobe seizures. McCabe, P.H., McNew, C.D., Michel, N.C. Arch. Neurol. (2001) [Pubmed]
  26. Medication status and polycystic ovary syndrome in women with bipolar disorder: a preliminary report. Rasgon, N.L., Altshuler, L.L., Gudeman, D., Burt, V.K., Tanavoli, S., Hendrick, V., Korenman, S. The Journal of clinical psychiatry. (2000) [Pubmed]
  27. Divalproex sodium and other medications for headache following craniotomy for acoustic neuroma. Hendler, N., Cashen, A., Morrison, C., Long, D., Holliday, M. Headache. (1995) [Pubmed]
  28. Effects of divalproex and atypical antipsychotic drugs on dopamine and acetylcholine efflux in rat hippocampus and prefrontal cortex. Huang, M., Li, Z., Ichikawa, J., Dai, J., Meltzer, H.Y. Brain Res. (2006) [Pubmed]
  29. Maintenance therapies for classic and other forms of bipolar disorder. Bowden, C.L., Lecrubier, Y., Bauer, M., Goodwin, G., Greil, W., Sachs, G., von Knorring L, n.u.l.l. Journal of affective disorders. (2000) [Pubmed]
  30. PET study of [(18)F]6-fluoro-L-dopa uptake in neuroleptic- and mood-stabilizer-naive first-episode nonpsychotic mania: effects of treatment with divalproex sodium. Yatham, L.N., Liddle, P.F., Shiah, I.S., Lam, R.W., Ngan, E., Scarrow, G., Imperial, M., Stoessl, J., Sossi, V., Ruth, T.J. The American journal of psychiatry. (2002) [Pubmed]
  31. Absorption of Theo-Dur Sprinkle with food: importance of types of meals and medication times. Pedersen, S. J. Allergy Clin. Immunol. (1986) [Pubmed]
  32. Randomized, placebo-controlled pilot study of divalproex sodium in the treatment of acute exacerbations of chronic schizophrenia. Wassef, A.A., Dott, S.G., Harris, A., Brown, A., O'Boyle, M., Meyer, W.J., Rose, R.M. Journal of clinical psychopharmacology. (2000) [Pubmed]
  33. Effects of divalproex sodium on 5-HT1A receptor function in healthy human males: hypothermic, hormonal, and behavioral responses to ipsapirone. Shiah, I.S., Yatham, L.N., Lam, R.W., Zis, A.P. Neuropsychopharmacology (1997) [Pubmed]
  34. Fatal seizures due to potential herb-drug interactions with Ginkgo biloba. Kupiec, T., Raj, V. Journal of analytical toxicology. (2005) [Pubmed]
  35. Long-term neurologic outcome in children with opsoclonus-myoclonus associated with neuroblastoma: a report from the Pediatric Oncology Group. Russo, C., Cohn, S.L., Petruzzi, M.J., de Alarcon, P.A. Med. Pediatr. Oncol. (1997) [Pubmed]
  36. Safety and efficacy of divalproex sodium monotherapy in partial epilepsy: a double-blind, concentration-response design clinical trial. Depakote Monotherapy for Partial Seizures Study Group. Beydoun, A., Sackellares, J.C., Shu, V. Neurology (1997) [Pubmed]
  37. Divalproex treatment for youth with explosive temper and mood lability: a double-blind, placebo-controlled crossover design. Donovan, S.J., Stewart, J.W., Nunes, E.V., Quitkin, F.M., Parides, M., Daniel, W., Susser, E., Klein, D.F. The American journal of psychiatry. (2000) [Pubmed]
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