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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Program Development

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Disease relevance of Program Development


Psychiatry related information on Program Development


High impact information on Program Development


Chemical compound and disease context of Program Development


Biological context of Program Development


Anatomical context of Program Development


Associations of Program Development with chemical compounds

  • During the Phase I, II, and III clinical development program, temafloxacin has demonstrated an excellent safety profile, with reported overall rates of adverse events comparable to quinolone and nonquinolone reference agents [27].
  • This paper describes results of a pooled analysis of four placebo-controlled studies included in the development program of the antidepressant nefazodone [28].
  • The recent development program for this class of antimicrobials as antimalarials makes our proof of principle of improved efficacy of triazines (compared with the gold standard treatment, pyrimethamine) against T. gondii especially promising [29].
  • Apart from slowing the development program by lowering the temperature to 15 degrees C and shortening the incubation time to 4 min, the essential step in the modification is the combined use of an EDTA and Tris-acetate buffer solution which stops the reduction of silver ions [30].
  • The unique preclinical profile of amifostine serves as the basis for the clinical development program for this new broad-spectrum cytoprotective agent [31].

Gene context of Program Development


Analytical, diagnostic and therapeutic context of Program Development


  1. Adjuvant aminoglutethimide therapy for postmenopausal patients with primary breast cancer: progress report. Coombes, R.C., Chilvers, C., Dowsett, M., Gazet, J.C., Ford, H.T., Bettelheim, R., Gordon, C., Smith, I.E., Zava, D., Powles, T.J. Cancer Res. (1982) [Pubmed]
  2. Metabolic bone disease and total parenteral nutrition: a progress report. Jeejeebhoy, K.N. Am. J. Clin. Nutr. (1998) [Pubmed]
  3. An open, multicenter trial of recombinant tissue plasminogen activator in acute stroke. A progress report. The rt-PA Acute Stroke Study Group. del Zoppo, G.J. Stroke (1990) [Pubmed]
  4. Long-term management of polycythemia vera with hydroxyurea: a progress report. Kaplan, M.E., Mack, K., Goldberg, J.D., Donovan, P.B., Berk, P.D., Wasserman, L.R. Semin. Hematol. (1986) [Pubmed]
  5. Zoledronic acid in the treatment of hypercalcemia of malignancy: results of the international clinical development program. Major, P.P., Coleman, R.E. Semin. Oncol. (2001) [Pubmed]
  6. Medication development for addictive disorders: the state of the science. Vocci, F.J., Acri, J., Elkashef, A. The American journal of psychiatry. (2005) [Pubmed]
  7. Nicotinic acid in the treatment of schizophrenias. Canadian Mental Health Association collaborative study: progress report II. Ban, T.A., Lehmann, H.E. Canadian Psychiatric Association journal. (1975) [Pubmed]
  8. Arp2/3 complex: advances on the inner workings of a molecular machine. Cooper, J.A., Wear, M.A., Weaver, A.M. Cell (2001) [Pubmed]
  9. A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. Rosenberg, S.A., Lotze, M.T., Muul, L.M., Chang, A.E., Avis, F.P., Leitman, S., Linehan, W.M., Robertson, C.N., Lee, R.E., Rubin, J.T. N. Engl. J. Med. (1987) [Pubmed]
  10. Editorial retrospective. Meningococcal A and other polysaccharide vaccines. A five-year progress report. Lepow, M.L., Gold, R. N. Engl. J. Med. (1983) [Pubmed]
  11. Dynamin and its partners: a progress report. Schmid, S.L., McNiven, M.A., De Camilli, P. Curr. Opin. Cell Biol. (1998) [Pubmed]
  12. Thrombolytic therapy vs primary percutaneous coronary intervention for myocardial infarction in patients presenting to hospitals without on-site cardiac surgery: a randomized controlled trial. Aversano, T., Aversano, L.T., Passamani, E., Knatterud, G.L., Terrin, M.L., Williams, D.O., Forman, S.A. JAMA (2002) [Pubmed]
  13. Diploma in Hospital Infection Control: a progress report. Cookson, B.D., Jenner, E.A., Roberts, C., Drasar, B., Ridgway, G. J. Hosp. Infect. (2001) [Pubmed]
  14. Nitrendipine in older patients with isolated systolic hypertension: second progress report on the SYST-EUR trial. Staessen, J., Bert, P., Bulpitt, C., De Cort, P., Fagard, R., Fletcher, A., Kivinen, P., Lehtomaki, E., Leonetti, G., O'Brien, E. Journal of human hypertension. (1993) [Pubmed]
  15. A progress report on the New Zealand Multicentre Parkinson's disease trial. A comparison of low-dose treatment with bromocriptine or L-dopa. Wallis, W.E. Eur. Neurol. (1988) [Pubmed]
  16. Overview: medications development for the treatment of drug abuse. Vocci, F., Chiang, C.N., Cummings, L., Hawks, R. NIDA Res. Monogr. (1995) [Pubmed]
  17. Studies on dapsone-resistant Mycobacterium leprae in leprosy patients of Gudiyatham Taluk, the leprosy control area of the Schieffelin Leprosy Research and Training Centre, Karigiri. 2. A progress report. Almeida, J.G., Christian, M., Chacko, C.J., Taylor, P.M., Fritschi, E.P. Leprosy review. (1983) [Pubmed]
  18. Geriatrics program development at Bowman Gray School of Medicine of Wake Forest University. Ettinger, W.H. Am. J. Med. (1994) [Pubmed]
  19. Ibandronate in osteoporosis: preclinical data and rationale for intermittent dosing. Bauss, F., Russell, R.G. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2004) [Pubmed]
  20. Myosin expression in hypertrophied fast twitch and slow tonic muscles of normal and dystrophic chickens. Kennedy, J.M., Zak, R., Gao, L. Muscle Nerve (1991) [Pubmed]
  21. Deconstructing the molecular mechanisms of cell cycle control in a mouse adrenocortical cell line: roles of ACTH. Rocha, K.M., Forti, F.L., Lepique, A.P., Armelin, H.A. Microsc. Res. Tech. (2003) [Pubmed]
  22. Zebrafish Hsp70 is required for embryonic lens formation. Evans, T.G., Yamamoto, Y., Jeffery, W.R., Krone, P.H. Cell Stress Chaperones (2005) [Pubmed]
  23. Absorption of isosorbide-5-mononitrate at specific sites in the gastrointestinal tract. Kramer, W.G. Journal of clinical pharmacology. (1994) [Pubmed]
  24. Engineering of the extracellular matrix: working toward neural stem cell programming and neurorestoration--concept and progress report. Liu, C.Y., Apuzzo, M.L., Tirrell, D.A. Neurosurgery (2003) [Pubmed]
  25. A progress report of the Marshall Islands nationwide thyroid study: an international cooperative scientific study. Takahashi, T., Simon, S.L., Trott, K.R., Fujimori, K., Nakashima, N., Arisawa, K., Schoemaker, M.J. Tohoku J. Exp. Med. (1999) [Pubmed]
  26. Pantographic records on TMJ dysfunction subjects treated with occlusal splints: a progress report. Roura, N., Clayton, J.A. The Journal of prosthetic dentistry. (1975) [Pubmed]
  27. Temafloxacin: a safe antibiotic for the elderly, patients with comorbidities, and other special populations. Pernet, A.G. Am. J. Med. (1991) [Pubmed]
  28. Nefazodone in the treatment of severe, melancholic, and recurrent depression. Marcus, R.N., Mendels, J. The Journal of clinical psychiatry. (1996) [Pubmed]
  29. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Mui, E.J., Jacobus, D., Milhous, W.K., Schiehser, G., Hsu, H., Roberts, C.W., Kirisits, M.J., McLeod, R. Antimicrob. Agents Chemother. (2005) [Pubmed]
  30. Differentiation of proteins in polyacrylamide gels by a modification of silver staining for the PhastSystem and a laser densitometer. Kierdorf, H., Melzer, H., Mann, H., Sieberth, H.G. Electrophoresis (1993) [Pubmed]
  31. The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine. Capizzi, R.L. Semin. Oncol. (1999) [Pubmed]
  32. Probing the structure of the mitochondrial channel, VDAC, by site-directed mutagenesis: a progress report. Blachly-Dyson, E., Peng, S.Z., Colombini, M., Forte, M. J. Bioenerg. Biomembr. (1989) [Pubmed]
  33. Celiac disease: a progress report. Antonioli, D.A. Mod. Pathol. (2003) [Pubmed]
  34. Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. West, A.B., Zimprich, A., Lockhart, P.J., Farrer, M., Singleton, A., Holtom, B., Lincoln, S., Hofer, A., Hill, L., Müller-Myhsok, B., Wszolek, Z.K., Hardy, J., Gasser, T. Eur. J. Hum. Genet. (2001) [Pubmed]
  35. Structure-function studies of aromatase and its inhibitors: a progress report. Chen, S., Zhang, F., Sherman, M.A., Kijima, I., Cho, M., Yuan, Y.C., Toma, Y., Osawa, Y., Zhou, D., Eng, E.T. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  36. The National Large Bowel Cancer Project: a progress report. Copeland, M.M. Cancer (1980) [Pubmed]
  37. A review of preclinical program development for evaluating injectable carriers for osteogenic factors. Seeherman, H., Li, R., Wozney, J. The Journal of bone and joint surgery. American volume. (2003) [Pubmed]
  38. Validation of new aromatase monoclonal antibodies for immunohistochemistry: progress report. Sasano, H., Edwards, D.P., Anderson, T.J., Silverberg, S.G., Evans, D.B., Santen, R.J., Ramage, P., Simpson, E.R., Bhatnagar, A.S., Miller, W.R. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  39. Parenteral nutrition: hospital to home. McCrae, J.D., O'Shea, R., Udine, L.M. Journal of the American Dietetic Association. (1993) [Pubmed]
  40. Transgenerational health promotion. Watson, N., Pulliam, L. Holistic nursing practice. (2000) [Pubmed]
  41. The Oregon Center for Complementary and Alternative Medicine career development program: innovation in research training for complementary and alternative medicine. Shaw, K.B., Mist, S., Dixon, M.W., Goldby, M., Weih, J., Bauer, V.K., Ritenbaugh, C. Teaching and learning in medicine. (2003) [Pubmed]
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