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MeSH Review

Antisocial Personality Disorder

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Disease relevance of Antisocial Personality Disorder


Psychiatry related information on Antisocial Personality Disorder


High impact information on Antisocial Personality Disorder

  • RESULTS: There was an 8-fold increased risk of drug disorders among the relatives of probands with drug disorders across a wide range of specific substances, including opioids, cocaine, cannabis, and alcohol, which is largely independent from the familial aggregation of both alcoholism and antisocial personality disorder [9].
  • RESULTS: Probands had significantly higher rates than comparisons of ADHD symptoms (11% vs 1%), antisocial personality disorders (18% vs 2%), and drug abuse disorders (16% vs 4%) [10].
  • The results suggest that the 5-HTT 'S' promoter polymorphism is associated with an increased risk for early onset alcoholism associated with antisocial personality disorder and impulsive, habitually violent behavior [11].
  • Gender differences in diagnosing antisocial personality disorder in methadone patients [12].
  • Methylphenidate in the treatment of aggression in two patients with antisocial personality disorder [7].

Chemical compound and disease context of Antisocial Personality Disorder


Biological context of Antisocial Personality Disorder


Anatomical context of Antisocial Personality Disorder


Gene context of Antisocial Personality Disorder


Analytical, diagnostic and therapeutic context of Antisocial Personality Disorder


  1. Cocaine users with antisocial personality improve HIV risk behaviors as much as those without antisocial personality. Compton, W.M., Cottler, L.B., Spitznagel, E.L., Ben Abdallah, A., Gallagher, T. Drug and alcohol dependence. (1998) [Pubmed]
  2. Association studies of polymorphisms of CYP2E1 gene in alcoholics with cirrhosis, antisocial personality, and normal controls. Parsian, A., Cloninger, C.R., Zhang, Z.H. Alcohol. Clin. Exp. Res. (1998) [Pubmed]
  3. Neuroendocrine responses to a glucose challenge in substance users with high and low levels of aggression, impulsivity, and antisocial personality. Fishbein, D.H., Dax, E., Lozovsky, D.B., Jaffe, J.H. Neuropsychobiology (1992) [Pubmed]
  4. P3 event-related potential amplitude and the risk for disinhibitory disorders in adolescent boys. Iacono, W.G., Carlson, S.R., Malone, S.M., McGue, M. Arch. Gen. Psychiatry (2002) [Pubmed]
  5. Heterogeneity of psychiatric diagnosis in treated opiate addicts. Rounsaville, B.J., Weissman, M.M., Kleber, H., Wilber, C. Arch. Gen. Psychiatry (1982) [Pubmed]
  6. Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Lappalainen, J., Long, J.C., Eggert, M., Ozaki, N., Robin, R.W., Brown, G.L., Naukkarinen, H., Virkkunen, M., Linnoila, M., Goldman, D. Arch. Gen. Psychiatry (1998) [Pubmed]
  7. Methylphenidate in the treatment of aggression in two patients with antisocial personality disorder. Stringer, A.Y., Josef, N.C. The American journal of psychiatry. (1983) [Pubmed]
  8. 'Borderline personality': diagnostic attitudes at the Maudsley Hospital. Tarnopolsky, A., Berelowitz, M. The British journal of psychiatry : the journal of mental science. (1984) [Pubmed]
  9. Familial transmission of substance use disorders. Merikangas, K.R., Stolar, M., Stevens, D.E., Goulet, J., Preisig, M.A., Fenton, B., Zhang, H., O'Malley, S.S., Rounsaville, B.J. Arch. Gen. Psychiatry (1998) [Pubmed]
  10. Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. Mannuzza, S., Klein, R.G., Bessler, A., Malloy, P., LaPadula, M. Arch. Gen. Psychiatry (1993) [Pubmed]
  11. Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Hallikainen, T., Saito, T., Lachman, H.M., Volavka, J., Pohjalainen, T., Ryynänen, O.P., Kauhanen, J., Syvälahti, E., Hietala, J., Tiihonen, J. Mol. Psychiatry (1999) [Pubmed]
  12. Gender differences in diagnosing antisocial personality disorder in methadone patients. Rutherford, M.J., Alterman, A.I., Cacciola, J.S., Snider, E.C. The American journal of psychiatry. (1995) [Pubmed]
  13. Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse. Moss, H.B., Yao, J.K., Panzak, G.L. Biol. Psychiatry (1990) [Pubmed]
  14. Plasma phospholipid essential fatty acids and prostaglandins in alcoholic, habitually violent, and impulsive offenders. Virkkunen, M.E., Horrobin, D.F., Jenkins, D.K., Manku, M.S. Biol. Psychiatry (1987) [Pubmed]
  15. Insulin secretion during the glucose tolerance test in antisocial personality. Virkkunen, M. The British journal of psychiatry : the journal of mental science. (1983) [Pubmed]
  16. Manic depressive illness concomitant with antisocial personality disorder: six case reports and review of the literature. Thorneloe, W.F., Crews, E.L. The Journal of clinical psychiatry. (1981) [Pubmed]
  17. Plasma lipid levels and psychologic characteristics in men. Freedman, D.S., Byers, T., Barrett, D.H., Stroup, N.E., Eaker, E., Monroe-Blum, H. Am. J. Epidemiol. (1995) [Pubmed]
  18. The effects of psychiatric comorbidity on response to an HIV prevention intervention. Compton, W.M., Cottler, L.B., Ben-Abdallah, A., Cunningham-Williams, R., Spitznagel, E.L. Drug and alcohol dependence. (2000) [Pubmed]
  19. Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. Lu, R.B., Lin, W.W., Lee, J.F., Ko, H.C., Shih, J.C. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
  20. No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan. Lu, R.B., Ko, H.C., Lee, J.F., Lin, W.W., Huang, S.Y., Wang, T.J., Wu, Y.S., Lu, T.E., Chou, Y.H. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  21. Auditory and visual P300 evoked potentials do not predict response to valproate treatment of aggression in patients with borderline and antisocial personality disorders. Reeves, R.R., Struve, F.A., Patrick, G. Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS). (2005) [Pubmed]
  22. Effects of antisocial personality, cocaine and opioid dependence, and gender on eye movement control. Ceballos, N.A., Bauer, L.O. Psychological reports. (2004) [Pubmed]
  23. Serotonin in alcoholic violent offenders. Virkkunen, M., Goldman, D., Linnoila, M. Ciba Found. Symp. (1996) [Pubmed]
  24. Dopamine transporter and D2-receptor density in late-onset alcoholism. Repo, E., Kuikka, J.T., Bergström, K.A., Karhu, J., Hiltunen, J., Tiihonen, J. Psychopharmacology (Berl.) (1999) [Pubmed]
  25. Comorbidity of alcohol dependence with attention-deficit hyperactivity disorder: differences in phenotype with increased severity of the substance disorder, but not in genotype (serotonin transporter and 5-hydroxytryptamine-2c receptor). Johann, M., Bobbe, G., Putzhammer, A., Wodarz, N. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
  26. Association of 5-HT1B receptor gene and antisocial behavior in alcoholism. Soyka, M., Preuss, U.W., Koller, G., Zill, P., Bondy, B. Journal of neural transmission (Vienna, Austria : 1996) (2004) [Pubmed]
  27. Sequence analysis of exon 8 of MAO-A gene in alcoholics with antisocial personality and normal controls. Parsian, A. Genomics (1999) [Pubmed]
  28. Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. Leal, J., Ziedonis, D., Kosten, T. Drug and alcohol dependence. (1994) [Pubmed]
  29. Intellectual, cognitive, and academic performance among sons of alcoholics, during the early school years: differences related to subtypes of familial alcoholism. Poon, E., Ellis, D.A., Fitzgerald, H.E., Zucker, R.A. Alcohol. Clin. Exp. Res. (2000) [Pubmed]
  30. Serum cholesterol in antisocial personality. Virkkunen, M. Neuropsychobiology (1979) [Pubmed]
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