The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Leukopoiesis


High impact information on Leukopoiesis

  • Genetic knockouts of CXCR4 and SDF-1 have delineated their critical role during embryonic cardiogenesis, leukopoiesis, and vasculogenesis [3].
  • The present results demonstrate that inflammation in CNS is clearly reduced during IL-6 deficiency and this effect is likely due to significant inhibition of BM leukopoiesis [4].
  • This case report demonstrates that GM-CSF might contribute to rapid reconstitution of leukopoiesis once methotrexate serum levels are in the subtoxic range [5].
  • It follows from the results that diclofenac is a suitable drug for enhancing leukopoiesis impaired by sublethal fractionated irradiation [6].
  • In the present study, stimulation of leukopoiesis by SMP was investigated in mice after induction of myelosuppression by the cytostatic agent cyclophosphamide (CP) [7].

Anatomical context of Leukopoiesis

  • On the other hand, a simple reproducible and highly sensitive method for the evaluation of the toxic effect of the chemicals on leukopoiesis has been provided by culturing mouse bone marrow cells in a semi-solid agar medium in the presence of purified colony stimulating factor (CSF) [8].

Associations of Leukopoiesis with chemical compounds


  1. Acquired pure red cell aplasia associated with chronic lymphocytic leukemia. Yoo, D., Pierce, L.E., Lessin, L.S. Cancer (1983) [Pubmed]
  2. The influence of N-methyl-N-beta-chloroethyl hydrazines on the mitotic index of Ehrlich ascites tumor cells and the leukopoiesis of the mouse. Braun, R., Wolf, G. Experientia (1977) [Pubmed]
  3. Cutting edge: CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant. Gupta, S.K., Pillarisetti, K. J. Immunol. (1999) [Pubmed]
  4. IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment. Penkowa, M., Hidalgo, J. Exp. Neurol. (2000) [Pubmed]
  5. GM-CSF in the treatment of a patient with severe methotrexate intoxication. Steger, G.G., Mader, R.M., Gnant, M.F., Marosi, C., Lenz, K., Jakesz, R. J. Intern. Med. (1993) [Pubmed]
  6. Modulation of haemopoietic radiation response of mice by diclofenac in fractionated treatment. Hofer, M., Pospísil, M., Pipalová, I., Holá, J. Physiological research / Academia Scientiarum Bohemoslovaca. (1996) [Pubmed]
  7. Stimulation of neutropoiesis by a special standardized mistletoe preparation after cyclophosphamide chemotherapy in mice. Weber, K., Mengs, U., Schwarz, T., Becker, H., Lentzen, H. Arzneimittel-Forschung. (1996) [Pubmed]
  8. Effects of various therapeutic agents on leukocytes in vivo and in vitro: competition between the cytotoxic drugs and colony stimulating factors (CSF) in the action on the proliferation of myeloid stem cells (CFU-C). Onoda, M., Shimizu, M., Shinoda, M., Tsuneoka, K., Shikita, M. J. Pharmacobio-dyn. (1980) [Pubmed]
  9. Effects of piracetam on erythropoiesis and leukopoiesis in rats. Nyagolov, Y., Dyankov, E., Ganchev, T. Acta physiologica et pharmacologica Bulgarica. (1993) [Pubmed]
  10. Role of radiotherapy in the management of cervical carcinoma. Traina, V., Restaino, A., Putignano, G., Miniello, G., Malvasi, A., Martulli, B. Eur. J. Gynaecol. Oncol. (1988) [Pubmed]
  11. The effect of the preparation "Peptichemio" on leukopoiesis and experimental tumours of animals compared with that of sarcolysin and thiophosphamide. Balitsky, K.P., Veksler, I.G., Tsapenko, V.F., Kavetsky, R.E. Giornale italiano di chemioterapia. (1980) [Pubmed]
WikiGenes - Universities