Disease relevance of Leukopoiesis

• Pure red cell aplasia (PRCA) represents selective failure of erythropoiesis in the absence of abnormalities in leukopoiesis or thrombocytopoiesis [1].
• The influence of N-methyl-N-beta-chloroethyl hydrazines on the mitotic index of Ehrlich ascites tumor cells and the leukopoiesis of the mouse [2].

High impact information on Leukopoiesis

• Genetic knockouts of CXCR4 and SDF-1 have delineated their critical role during embryonic cardiogenesis, leukopoiesis, and vasculogenesis [3].
• The present results demonstrate that inflammation in CNS is clearly reduced during IL-6 deficiency and this effect is likely due to significant inhibition of BM leukopoiesis [4].
• This case report demonstrates that GM-CSF might contribute to rapid reconstitution of leukopoiesis once methotrexate serum levels are in the subtoxic range [5].
• It follows from the results that diclofenac is a suitable drug for enhancing leukopoiesis impaired by sublethal fractionated irradiation [6].
• In the present study, stimulation of leukopoiesis by SMP was investigated in mice after induction of myelosuppression by the cytostatic agent cyclophosphamide (CP) [7].

Anatomical context of Leukopoiesis

• On the other hand, a simple reproducible and highly sensitive method for the evaluation of the toxic effect of the chemicals on leukopoiesis has been provided by culturing mouse bone marrow cells in a semi-solid agar medium in the presence of purified colony stimulating factor (CSF) [8].

Associations of Leukopoiesis with chemical compounds

• Effects of piracetam on erythropoiesis and leukopoiesis in rats [9].
• Lithium-carbonate action during radiation therapy has been studied, valuing the positive effect on leukopoiesis and the consequent better clinical conditions of the patients in course of treatment [10].
• The effect of the preparation "Peptichemio" on leukopoiesis and experimental tumours of animals compared with that of sarcolysin and thiophosphamide [11].
• Erythro- and leukopoiesis in rats after 10-day treatment with piracetam (2 x 200 mg/kg b.w.) were studied [9].

References