Disease relevance of Red-Cell Aplasia, Pure

• We treated a 74-year-old man who had B-cell chronic lymphocytic leukemia and pure red cell aplasia that was refractory to cytotoxic and corticosteroid therapy with equine antithymocyte globulin and methylprednisolone sodium succinate [1].
• Chronic pure red cell aplasia may be another extra-articular manifestation of rheumatoid arthritis and should be considered when severe anemia develops in the absence of blood loss or hemolysis [2].
• B19 parvovirus is pathogenic in humans, causing fifth disease, transient aplastic crisis, some cases of hydrops fetalis, and acquired pure red cell aplasia [3].
• From 1998 to 2004, nearly 200 epoetin-treated persons with chronic kidney disease developed antibodies to epoetin, resulting in pure red cell aplasia (PRCA) [4].
• Combined pure red cell aplasia and primary autoimmune hypothyroidism in systemic lupus erythematosus [5].

High impact information on Red-Cell Aplasia, Pure

• Successful treatment of a patient with a thymoma and pure red-cell aplasia with octreotide and prednisone [6].
• Autoantibodies against erythropoietin in a patient with pure red-cell aplasia [7].
• Pure red cell aplasia associated with sodium valproate therapy [8].
• Pure red cell aplasia caused by chlormadinone [9].
• Pure red-cell aplasia with fludarabine for chronic lymphocytic leukaemia [10].

Chemical compound and disease context of Red-Cell Aplasia, Pure

• Successful treatment of pure red-cell aplasia with cyclosporin [11].
• Pure red cell aplasia associated with sulphasalazine [12].
• This specific erythropoietic inhibitor persisted in lower titer in the patient's serum even after an azathioprine-induced remission of pure red cell aplasia, indicating the possible need for maintenance immunosuppressive therapy [2].
• Cyclosporine for pure red cell aplasia [13].
• High-dose intravenous methylprednisolone for constitutional pure red cell aplasia [14].

Biological context of Red-Cell Aplasia, Pure

• In the immunocompromised host persistent B19 infection is manifested as pure red cell aplasia and chronic anemia [15].
• Immune suppression of hematopoiesis has now been described in pure red cell aplasia, immune panleukopenia, systemic lupus erythematosus, atypical cases of aplastic anemia and miscellaneous other hematologic diseases [16].
• Demonstration of three distinct immunological disorders on erythropoiesis in a patient with pure red cell aplasia and autoimmune haemolytic anaemia associated with thymoma [17].
• Antibody-mediated pure red cell aplasia (PRCA): epidemiology, immunogenicity and risks [18].
• Spontaneous remission in pure red cell aplasia associated with thymoma [19].

Anatomical context of Red-Cell Aplasia, Pure

• Cats viremic with feline leukemia virus subgroup C (FeLV-C) develop pure red cell aplasia (PRCA) characterized by the loss of detectable late erythroid progenitors (CFU-E) in marrow culture [20].
• However, it carries additional risks of hemolytic reactions, delayed red blood cell (RBC) engraftment, and pure red cell aplasia (PRCA) [21].
• To determine whether abnormal BFUE proliferating effect of T cells could explain the pure red cell aplasia in chronic lymphocytic leukemia (CLL-PRCA), we investigated the erythropoietic function of T and null cells in four patients with CLL-PRCA and compared results to three patients with idiopathic pure red cell aplasia (I-PRCA) and normals [22].
• A 40-year-old woman with acute myeloid leukemia in first remission developed pure red cell aplasia after a T cell-depleted ABO-incompatible bone marrow transplant from her HLA-identical sister [23].
• Morphological characteristics of lymphocytes and the response to cyclosporine treatment have revealed some unique patients with pure red cell aplasia [24].

Gene context of Red-Cell Aplasia, Pure

• High-titered spontaneous interferon (IFN) antibodies were detected in a patient with pure red cell aplasia (PRCA), a benign mediastinal tumor, and recurrent cutaneous carcinomas [25].
• The data previously described by us on somatostatin receptor scintigraphy showing high uptake of indium-labelled octreotide by thymic masses and the successful treatment of a patient with thymoma and pure red cell aplasia with octreotide and prednisone has provided us the rationale for using such treatment in patients with advanced thymoma [26].
• Pure red cell aplasia in a case of Ph negative BCR/ABL rearranged CML with t(12;14)(q23;p11) [27].
• Clinical characteristics of erythropoietin-associated pure red cell aplasia [28].
• Three patients with severe, deforming, and long-standing rheumatoid arthritis developed pure red cell aplasia that did not remit after withdrawal of medications, ran a chronic course, and in two patients remitted only after cytotoxic immunosuppressive treatment [2].

Analytical, diagnostic and therapeutic context of Red-Cell Aplasia, Pure

• Anti-erythropoietin antibody-mediated pure red cell aplasia after treatment with recombinant erythropoietin products: recommendations for minimization of risk [29].
• A patient was observed who developed wheals at the sites of subcutaneous injections of epoetin-alpha before the manifestation of pure red cell aplasia (PRCA) [30].
• He initially responded well to Epoetin alpha (Eprex) but subsequently developed EPO antibodies and pure red cell aplasia (PRCA), becoming blood transfusion dependent [31].
• Long-term parvovirus B19 viraemia associated with pure red cell aplasia after allogeneic bone marrow transplantation [32].
• Azathioprine-associated pure red cell aplasia in patients with a renal allograft is a rare complication [33].

References