Disease relevance of Acquired Hyperostosis Syndrome

• In addition to OPLLS in patients of Asian origin, the condition has also been described in association with ossifying diseases, including ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) but not previously, to our knowledge, with SAPHO syndrome [1].
• In case of diagnostic doubts F-18 FDG PET could be recommended in order to discriminate bland osteomyelitis from bacterial osteomyelitis or from bone malignancy when SAPHO-syndrome is assumed [2].

High impact information on Acquired Hyperostosis Syndrome

• Successful treatment of SAPHO syndrome with zoledronic acid [3].
• Sustained response to doxycycline therapy in two patients with SAPHO syndrome [4].
• The usefulness of bone remodelling markers in predicting the efficacy of pamidronate treatment in SAPHO syndrome [5].
• METHODS: Between the years 1999 and 2003 we treated 10 patients with the SAPHO syndrome who did not respond to NSAIDs, oral corticosteroids, colchicine, methotrexate, sulphasalazine or infliximab [6].
• METHODS: A retrospective observational study of all children with SAPHO syndrome treated with pamidronate between 1996 and 2003 at a tertiary rheumatology centre [7].

Chemical compound and disease context of Acquired Hyperostosis Syndrome

• We report our clinical experience with intravenous pamidronate in SAPHO syndrome [6].
• Successful treatment of SAPHO syndrome with leflunomide. Report of two cases [8].
• CONCLUSION: Tc-99m MDP bone scanning may be helpful in diagnosing arthritis as associated with the SAPHO syndrome [9].
• The SAPHO syndrome improved considerably during the course of this pregnancy and treatment with indomethacin ceased during gestation [10].

Gene context of Acquired Hyperostosis Syndrome

• Data from patients with the diagnostic criteria of SAPHO syndrome were analysed for clinical features, biological data (HLA B antigen), and pelvic and spine x rays [11].
• Ankylosing spondylitis with exuberant sclerosis or SAPHO syndrome [12]?
• Bone scintigraphy using Tc-99m DPD and F18-FDG in a patient with SAPHO syndrome [2].
• FDG PET helpful for diagnosing SAPHO syndrome [13].
• Stress-induced SAPHO syndrome [14].

Analytical, diagnostic and therapeutic context of Acquired Hyperostosis Syndrome

• A prospective multicentre study is necessary to assess the role and long-term safety of pamidronate in the management of childhood SAPHO syndrome[7]

References