Disease relevance of phosphonomethylphosphonic acid

• A clinical comparison of Tc-99m HEDP and Tc-99m MDP in the detection of bone metastases: concise communication [1].
• In the other two studies, the scintigrams were falsely interpreted as indicating osteomyelitis and showed congruent, increased accumulation of both Tc-99m MDP and Ga-67 (with the latter of similar or greater intensity) [2].
• Of 18 studies in patients with infarction, the combined scintigrams were correctly interpreted in 16 and showed either no local accumulation of Ga-67 or less accumulation than that of Tc-99m MDP at symptomatic sites [2].
• Soft-tissue uptake of Tc-99m MDP in secondary scrotal lymphedema [3].
• Twenty-four symptomatic patients with symptoms of active Paget's disease of bone were evaluated, during the course of their therapy, a total of 71 times (24 baseline and 47 follow-up examinations) by serial alkaline phosphatase levels (AP), Tc-99m MDP bone scans, and radionuclide blood-flow studies [4].

Psychiatry related information on phosphonomethylphosphonic acid

• Tc-99m MDP appearance and resolution in a cerebral infarct in a patient with dementia [5].

High impact information on phosphonomethylphosphonic acid

• Infected knee prosthesis: diagnosis with In-111 leukocyte, Tc-99m sulfur colloid, and Tc-99m MDP imaging [6].
• Uptake of Tc-99m MDP in muscle anticipating clinical evidence of a carcinomatous myopathy [7].
• To compare the efficacy of Tc-99m HMDP and Tc-99m MDP to define skeletal lesions, 28 adult patients were examined in a double-blind, randomized, crossover study [8].
• Comparison of tc-99m MDP, HMDP, and DPD with respect to bone-to-soft tissue ratios [9].
• Gallium-67 scintigraphy was positive earlier in the course of infection than Tc-99m MDP scintigraphy [10].

Chemical compound and disease context of phosphonomethylphosphonic acid

• This study aimed to elucidate the potential role of FDG-PET compared with technetium-99m methylene diphosphonate (Tc-99m MDP) bone scintigraphy in the evaluation of bony metastasis in esophageal carcinoma patients [11].
• A case of calcifying soft tissue malignant fibrous histiocytoma (MFH) which showed a concentration of Tc-99m MDP and Ga-67 citrate, is presented [12].
• Incidental visualization of hepatic hemangioma during Tc-99m (v) DMSA, Tl-201, and Tc-99m MDP imaging [13].
• Demonstration of spinal osteomyelitis with Ga-67 citrate, Tc-99m MDP, and Tc-99m ciprofloxacin with provisionally negative results on MRI [14].
• The observations in this case lend credence to the hypothesis of Tc-99m MDP binding by immature collagen in the production of a super scan in metabolic bone disease, as well as that of Tc-99m MDP chemisorption to calcium hydroxyapatite crystal in fracture healing [15].

Biological context of phosphonomethylphosphonic acid

• Computer analysis of Tc-99m DPD and Tc-99m MDP kinetics in humans: concise communication [16].
• Estimation of the effect of a preinjection of Tc-99m MDP on lumbar spine bone mineral density determinations [17].
• The intense immediate accumulation of Tc-99m MDP in this case may be attributed to increased microvascular permeability [18].
• The authors conclude that Tc-99m MDP may be useful in evaluation of acute renal failure after exercise with flank pain and patchy renal vasoconstriction due to acute tubular necrosis [19].

Anatomical context of phosphonomethylphosphonic acid

• The correlation between prostaglandin E (PgE) and scintigrams of bone (Tc-99m MDP) and bone marrow (Tc-99m SC) was investigated in normal and VX-2-bearing rabbits [20].
• Localization of Tc-99m MDP in epiphyseal growth plates of rats [21].
• The initial qualitative score assigned to a joint using Tc-99m-MDP was in agreement with the calculated quantitative ratio except for the knee joint [22].
• The authors report Tc-99m pertechnetate, Tc-99m MDP and radioiodine imaging features in a 33-year-old male patient with metastatic insular carcinoma of the thyroid [23].
• Fusion lymphoscintigraphy with a 24-hour Tc-99m MDP bone scan for sentinel lymph node detection and imaging [24].

Associations of phosphonomethylphosphonic acid with other chemical compounds

• Quantitation of osteoblast-like cell mineralization on tissue culture polystyrene and Ti-6Al-4V alloy disks by Tc-99m-MDP labeling and imaging in vitro [25].
• Technetium-99m-methylene diphosphonate (Tc-99m MDP) scintimammography (SMB) was used to investigate palpable breast masses during routine presurgical bone scintigraphy, for women at high risk for cancer and who were candidates for surgery or excisional biopsy [26].
• Lutein cyst inadvertently detected on Tc-99m MDP whole-body bone scintigraphy [27].
• Comparison of Tc-99m HIG and three-phase Tc-99m MDP bone scintigraphy for evaluating the efficacy of Yttrium-90 silicate radionuclide synovectomy [28].
• Uptake of gallium within the cardiac region, in association with minimal rib uptake of Tc-99m MDP, strongly supported the existence of infection within the pericardium [29].

Gene context of phosphonomethylphosphonic acid

• Quantitative sacroiliac and lumbar spine radio-isotope (Tc-99m MDP) scans were performed in 42 patients with ankylosing spondylitis, and repeated 12 months later in 25 [30].
• Improvement using Tc-99m-MDP during the first 2 weeks of NSAID therapy was noted in the minimally inflamed wrist by joint/soft tissue measurement and in the maximally affected MCP joint by joint/bone ratio [22].
• These findings were supported by analyses of the non-invasive Tc-99m-MDP images, which demonstrated significantly greater uptake of Tc-99m-MDP adjacent to FGF-1-treated implants (P < .05) [31].
• The objective of this study was to compare the uptake behaviors of Tc-99m HIG and Tc-99m MDP in RA and variants of rheumatoid arthritis (VRA) [32].
• There were discordant results between the Tc-99m MDP bone scans and F-18 FDG CoDe PET [33].

Analytical, diagnostic and therapeutic context of phosphonomethylphosphonic acid

• Subacute and chronic bone infections: diagnosis using In-111, Ga-67 and Tc-99m MDP bone scintigraphy, and radiography [34].
• Tc-99m MDP and Tc-99m PPi concentrations in these hearts were significantly above control (undamaged) heart levels, producing positive gamma-camera images [35].
• Blood flow and tracer uptake in normal and abnormal canine bone: comparisons with Sr-85 microspheres, Kr-81m, and Tc-99m MDP [36].
• With one exception the Tc-99m MDP scans proved to be reliable in indicating the potential for continued growth after reimplantation [37].
• Asymptomatic total hip prosthesis: natural history determined using Tc-99m MDP bone scans [38].

References