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Chemical Compound Review

Tc-99m Mdp     phosphonomethylphosphonic acid; technetium

Synonyms: AN-MDP (TN), MOLI000842, NSC-749127, NSC749127, AC1L4I1L, ...
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Disease relevance of phosphonomethylphosphonic acid

  • A clinical comparison of Tc-99m HEDP and Tc-99m MDP in the detection of bone metastases: concise communication [1].
  • In the other two studies, the scintigrams were falsely interpreted as indicating osteomyelitis and showed congruent, increased accumulation of both Tc-99m MDP and Ga-67 (with the latter of similar or greater intensity) [2].
  • Of 18 studies in patients with infarction, the combined scintigrams were correctly interpreted in 16 and showed either no local accumulation of Ga-67 or less accumulation than that of Tc-99m MDP at symptomatic sites [2].
  • Soft-tissue uptake of Tc-99m MDP in secondary scrotal lymphedema [3].
  • Twenty-four symptomatic patients with symptoms of active Paget's disease of bone were evaluated, during the course of their therapy, a total of 71 times (24 baseline and 47 follow-up examinations) by serial alkaline phosphatase levels (AP), Tc-99m MDP bone scans, and radionuclide blood-flow studies [4].

Psychiatry related information on phosphonomethylphosphonic acid


High impact information on phosphonomethylphosphonic acid


Chemical compound and disease context of phosphonomethylphosphonic acid


Biological context of phosphonomethylphosphonic acid


Anatomical context of phosphonomethylphosphonic acid

  • The correlation between prostaglandin E (PgE) and scintigrams of bone (Tc-99m MDP) and bone marrow (Tc-99m SC) was investigated in normal and VX-2-bearing rabbits [20].
  • Localization of Tc-99m MDP in epiphyseal growth plates of rats [21].
  • The initial qualitative score assigned to a joint using Tc-99m-MDP was in agreement with the calculated quantitative ratio except for the knee joint [22].
  • The authors report Tc-99m pertechnetate, Tc-99m MDP and radioiodine imaging features in a 33-year-old male patient with metastatic insular carcinoma of the thyroid [23].
  • Fusion lymphoscintigraphy with a 24-hour Tc-99m MDP bone scan for sentinel lymph node detection and imaging [24].

Associations of phosphonomethylphosphonic acid with other chemical compounds


Gene context of phosphonomethylphosphonic acid

  • Quantitative sacroiliac and lumbar spine radio-isotope (Tc-99m MDP) scans were performed in 42 patients with ankylosing spondylitis, and repeated 12 months later in 25 [30].
  • Improvement using Tc-99m-MDP during the first 2 weeks of NSAID therapy was noted in the minimally inflamed wrist by joint/soft tissue measurement and in the maximally affected MCP joint by joint/bone ratio [22].
  • These findings were supported by analyses of the non-invasive Tc-99m-MDP images, which demonstrated significantly greater uptake of Tc-99m-MDP adjacent to FGF-1-treated implants (P < .05) [31].
  • The objective of this study was to compare the uptake behaviors of Tc-99m HIG and Tc-99m MDP in RA and variants of rheumatoid arthritis (VRA) [32].
  • There were discordant results between the Tc-99m MDP bone scans and F-18 FDG CoDe PET [33].

Analytical, diagnostic and therapeutic context of phosphonomethylphosphonic acid


  1. A clinical comparison of Tc-99m HEDP and Tc-99m MDP in the detection of bone metastases: concise communication. Fogelman, I., Citrin, D.L., McKillop, J.H., Turner, J.G., Bessent, R.G., Greig, W.R. J. Nucl. Med. (1979) [Pubmed]
  2. Osteomyelitis and infarction in sickle cell hemoglobinopathies: differentiation by combined technetium and gallium scintigraphy. Amundsen, T.R., Siegel, M.J., Siegel, B.A. Radiology. (1984) [Pubmed]
  3. Soft-tissue uptake of Tc-99m MDP in secondary scrotal lymphedema. Rao, B.R., Hodgens, D.W. J. Nucl. Med. (1983) [Pubmed]
  4. Observations on serial radionuclide blood-flow studies in Paget's disease: concise communication. Boudreau, R.J., Lisbona, R., Hadjipavlou, A. J. Nucl. Med. (1983) [Pubmed]
  5. Tc-99m MDP appearance and resolution in a cerebral infarct in a patient with dementia. Moallem, A. Clinical nuclear medicine. (1991) [Pubmed]
  6. Infected knee prosthesis: diagnosis with In-111 leukocyte, Tc-99m sulfur colloid, and Tc-99m MDP imaging. Palestro, C.J., Swyer, A.J., Kim, C.K., Goldsmith, S.J. Radiology. (1991) [Pubmed]
  7. Uptake of Tc-99m MDP in muscle anticipating clinical evidence of a carcinomatous myopathy. Lentle, B.C., Russell, A.S. J. Nucl. Med. (1984) [Pubmed]
  8. Relative lesion detection ability of Tc-99m HMDP and Tc-99m MDP: concise communication. Van Duzee, B.F., Schaefer, J.A., Ball, J.D., Chilton, H.M., Cowan, R.J., Kuni, C., Trow, R., Watson, N.E. J. Nucl. Med. (1984) [Pubmed]
  9. Comparison of tc-99m MDP, HMDP, and DPD with respect to bone-to-soft tissue ratios. Buell, U., Kirsch, C.M., Kleinhans, E., Jäger, B. J. Nucl. Med. (1983) [Pubmed]
  10. Scintigraphic detection of osteomyelitis with Tc-99m MDP and Ga-67 citrate: concise communication. Graham, G.D., Lundy, M.M., Frederick, R.J., Hartshorne, M.F., Berger, D.E. J. Nucl. Med. (1983) [Pubmed]
  11. Comparison between whole-body positron emission tomography and bone scintigraphy in evaluating bony metastases of esophageal carcinomas. Kato, H., Miyazaki, T., Nakajima, M., Takita, J., Kimura, H., Faried, A., Sohda, M., Fukai, Y., Masuda, N., Fukuchi, M., Manda, R., Ojima, H., Tsukada, K., Kuwano, H., Oriuchi, N., Endo, K. Anticancer Res. (2005) [Pubmed]
  12. Tc-99m-methylene diphosphonate (Tc-99 MDP) and Ga-67 concentration in soft tissue malignant fibrous histiocytoma (MFH): case report. Kida, T., Hoshi, K., Hoshino, R., Fujita, Y., Munakata, S., Yanagisawa, M. Annals of nuclear medicine. (1993) [Pubmed]
  13. Incidental visualization of hepatic hemangioma during Tc-99m (v) DMSA, Tl-201, and Tc-99m MDP imaging. Adalet, I., Kocak, M., Oguz, H., Alagol, F., Cantez, S. Clinical nuclear medicine. (1995) [Pubmed]
  14. Demonstration of spinal osteomyelitis with Ga-67 citrate, Tc-99m MDP, and Tc-99m ciprofloxacin with provisionally negative results on MRI. Jayaraman, S., Al-Nahhas, A.M., Vivian, G., Gilbert, T.J., Hughes, P.M. Clinical nuclear medicine. (2000) [Pubmed]
  15. Pathologic fractures in a patient with renal osteodystrophy. Failure of early detection on bone scans. Campeau, R.J., Bellah, R.D., Varma, D.G. Clinical nuclear medicine. (1987) [Pubmed]
  16. Computer analysis of Tc-99m DPD and Tc-99m MDP kinetics in humans: concise communication. Mele, M., Conte, E., Fratello, A., Pasculli, D., Pieralice, M., D'Addabbo, A. J. Nucl. Med. (1983) [Pubmed]
  17. Estimation of the effect of a preinjection of Tc-99m MDP on lumbar spine bone mineral density determinations. Rosenthall, L. Clinical nuclear medicine. (1992) [Pubmed]
  18. Increased activity on immediate phase of bone imaging does not always indicate increased blood volume. Webster, D.L., Hurwitz, G.A., DeVeber, L.L., Troster, M., Driedger, A.A. Clinical nuclear medicine. (1986) [Pubmed]
  19. Diffuse increased renal uptake on bone scintigraphy in acute tubular necrosis. Watanabe, N., Shimizu, M., Kageyama, M., Kamei, T., Seto, H., Kakishita, M. Clinical nuclear medicine. (1994) [Pubmed]
  20. Effects of prostaglandin on experimental bone malignancy and on scintigrams of bone and marrow. Otsuka, N., Ito, Y., Nagai, K., Terashima, H., Yanagimoto, S., Muranaka, A. J. Nucl. Med. (1981) [Pubmed]
  21. Localization of Tc-99m MDP in epiphyseal growth plates of rats. Christensen, S.B., Krogsgaard, O.W. J. Nucl. Med. (1981) [Pubmed]
  22. Quantitative scintigraphy using radiophosphate and radiogallium in patients with rheumatoid arthritis. Tannenbaum, H., Rosenthall, L., Arzoumanian, A. Clinical and experimental rheumatology. (1987) [Pubmed]
  23. Metastatic insular thyroid carcinoma: visualized on Tc-99m pertechnetate, Tc-99m MDP and iodine-131 scintigraphy; a review of the literature for other radionuclide agents. Kiratli, P.O., Kara, P.P., Ergün, E.L., Gedikoğlu, G. Annals of nuclear medicine. (2004) [Pubmed]
  24. Fusion lymphoscintigraphy with a 24-hour Tc-99m MDP bone scan for sentinel lymph node detection and imaging. Tatini, V.R., Dworkin, H.J. Clinical nuclear medicine. (2001) [Pubmed]
  25. Quantitation of osteoblast-like cell mineralization on tissue culture polystyrene and Ti-6Al-4V alloy disks by Tc-99m-MDP labeling and imaging in vitro. Wang, H., Gerbaudo, V.H., Hobbs, L.W., Spector, M. Bone (2005) [Pubmed]
  26. Technetium-99m methylene diphosphonate scintimammography for evaluation of palpable breast masses. Lee, J.K., Kao, C.H., Sun, S.S. Oncol. Rep. (1999) [Pubmed]
  27. Lutein cyst inadvertently detected on Tc-99m MDP whole-body bone scintigraphy. Kida, T., Takahashi, S. Clinical nuclear medicine. (1998) [Pubmed]
  28. Comparison of Tc-99m HIG and three-phase Tc-99m MDP bone scintigraphy for evaluating the efficacy of Yttrium-90 silicate radionuclide synovectomy. Arzu Gencoglu, E., Aras, G., Kucuk, O., Atay, G., Tutak, I., Ataman, S., Soylu, A., Ibis, E. Clinical nuclear medicine. (2003) [Pubmed]
  29. Detection of postcardiotomy bacterial pericarditis with gallium-67 citrate. Zuckier, L.S., Weissmann, H.S., Goldman, M.J., Brodman, R., Kamholz, S.L., Freeman, L.M. Clinical nuclear medicine. (1986) [Pubmed]
  30. Quantitative radio-isotope scanning in ankylosing spondylitis: a clinical, laboratory and computerised tomographic study. Taylor, H.G., Gadd, R., Beswick, E.J., Venkateswaran, M., Dawes, P.T. Scand. J. Rheumatol. (1991) [Pubmed]
  31. Analysis of Ti-6Al-4V implants placed with fibroblast growth factor 1 in rat tibiae. McCracken, M., Lemons, J.E., Zinn, K. The International journal of oral & maxillofacial implants. (2001) [Pubmed]
  32. Comparison of Tc-99m MDP, Tc-99m HSA and Tc-99m HIG uptake in rheumatoid arthritis and its variants. Sahin, M., Bernay, I., Basoglu, T., Canturk, F. Annals of nuclear medicine. (1999) [Pubmed]
  33. Dichotomy between Tc-99m MDP bone scan and fluorine-18 fluorodeoxyglucose coincidence detection positron emission tomography in patients with non-Hodgkin's lymphoma. Lee, J., Park, C.H., Kim, H.C., Kim, H.S. Clinical nuclear medicine. (2000) [Pubmed]
  34. Subacute and chronic bone infections: diagnosis using In-111, Ga-67 and Tc-99m MDP bone scintigraphy, and radiography. Al-Sheikh, W., Sfakianakis, G.N., Mnaymneh, W., Hourani, M., Heal, A., Duncan, R.C., Burnett, A., Ashkar, F.S., Serafini, A.N. Radiology. (1985) [Pubmed]
  35. Myocardial uptake of Tc-99m skeletal agents in the rat after experimental induction of microscopic foci of injury. Miller, D.G., Gilmour, R.F., Grossman, Z.D., Mallov, S., Wistow, B.W., Rohner, R.F. J. Nucl. Med. (1977) [Pubmed]
  36. Blood flow and tracer uptake in normal and abnormal canine bone: comparisons with Sr-85 microspheres, Kr-81m, and Tc-99m MDP. Lavender, J.P., Khan, R.A., Hughes, S.P. J. Nucl. Med. (1979) [Pubmed]
  37. The use of Tc-99m MDP bone scanning in the study of vascularized bone implants: concise communication. Dee, P., Lambruschi, P.G., Hiebert, J.M. J. Nucl. Med. (1981) [Pubmed]
  38. Asymptomatic total hip prosthesis: natural history determined using Tc-99m MDP bone scans. Utz, J.A., Lull, R.J., Galvin, E.G. Radiology. (1986) [Pubmed]
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