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Disease relevance of Osteomyelitis


High impact information on Osteomyelitis

  • CONCLUSIONS--Noninvasive testing adds significant expense to the treatment of patients with NIDDM in whom pedal osteomyelitis is suspected, and such testing may result in little improvement in health outcomes [1].
  • Predisposing factors leading to osteomyelitis included parenteral drug abuse in six patients and pelvic surgery in one patient [6].
  • Patients with nonautoimmune inflammation (osteomyelitis or tuberculosis) had normal MHC class I expression [7].
  • The commonest antibiotic used was clindamycin, and chronic osteomyelitis did not develop in patients treated with this antibiotic, whereas all 9 patients who had chronic sequelae necessitating sequestrectomy had received cloxacillin either alone or in combination with another antibiotic [8].
  • Ketoconazole and blastomycotic osteomyelitis [9].

Chemical compound and disease context of Osteomyelitis


Biological context of Osteomyelitis


Anatomical context of Osteomyelitis


Gene context of Osteomyelitis


Analytical, diagnostic and therapeutic context of Osteomyelitis


  1. Foot infections in diabetic patients. Decision and cost-effectiveness analyses. Eckman, M.H., Greenfield, S., Mackey, W.C., Wong, J.B., Kaplan, S., Sullivan, L., Dukes, K., Pauker, S.G. JAMA (1995) [Pubmed]
  2. Dysregulation of the in vivo production of interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Pathogenetic implications. Chikanza, I.C., Roux-Lombard, P., Dayer, J.M., Panayi, G.S. Arthritis Rheum. (1995) [Pubmed]
  3. Treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis with ciprofloxacin or vancomycin alone or in combination with rifampin. Henry, N.K., Rouse, M.S., Whitesell, A.L., McConnell, M.E., Wilson, W.R. Am. J. Med. (1987) [Pubmed]
  4. Efficacy of oral fleroxacin in bone and joint infections. Green, S.L. Am. J. Med. (1993) [Pubmed]
  5. Quinolone resistance. Susceptibility data from a 300-bed community hospital. Parry, M.F., Panzer, K.B., Yukna, M.E. Am. J. Med. (1989) [Pubmed]
  6. Osteomyelitis of the pubis. Report of seven cases. del Busto, R., Quinn, E.L., Fisher, E.J., Madhavan, T. JAMA (1982) [Pubmed]
  7. Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity. Fu, Y., Nathan, D.M., Li, F., Li, X., Faustman, D.L. J. Clin. Invest. (1993) [Pubmed]
  8. Acute osteomyelitis in a district general hospital. Glover, S.C., McKendrick, M.W., Padfield, C., Geddes, A.M., Dwyer, N.S. Lancet (1982) [Pubmed]
  9. Ketoconazole and blastomycotic osteomyelitis. Claflin, K., Milbauer, J., Sullivan, B. Ann. Intern. Med. (1983) [Pubmed]
  10. Ketoconazole for treatment of disseminated coccidioidomycosis. Catanzaro, A., Einstein, H., Levine, B., Ross, J.B., Schillaci, R., Fierer, J., Friedman, P.J. Ann. Intern. Med. (1982) [Pubmed]
  11. Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Chikanza, I.C., Petrou, P., Kingsley, G., Chrousos, G., Panayi, G.S. Arthritis Rheum. (1992) [Pubmed]
  12. Randomized trial of ciprofloxacin compared with other antimicrobial therapy in the treatment of osteomyelitis. Greenberg, R.N., Tice, A.D., Marsh, P.K., Craven, P.C., Reilly, P.M., Bollinger, M., Weinandt, W.J. Am. J. Med. (1987) [Pubmed]
  13. Successful oral treatment of methicillin-resistant Staphylococcus aureus osteomyelitis using ciprofloxacin. Westblom, T.U., Abele, B., Blount, R., Hyslop, D.L. Am. J. Med. (1988) [Pubmed]
  14. Osteomyelitis beneath pressure sores. Sugarman, B., Hawes, S., Musher, D.M., Klima, M., Young, E.J., Pircher, F. Arch. Intern. Med. (1983) [Pubmed]
  15. In vivo comparison of Dhvar-5 and gentamicin in an MRSA osteomyelitis prevention model. Faber, C., Hoogendoorn, R.J., Stallmann, H.P., Lyaruu, D.M., van Nieuw Amerongen, A., Wuisman, P.I. J. Antimicrob. Chemother. (2004) [Pubmed]
  16. Chronic recurrent multifocal osteomyelitis (CRMO): evidence for a susceptibility gene located on chromosome 18q21.3-18q22. Golla, A., Jansson, A., Ramser, J., Hellebrand, H., Zahn, R., Meitinger, T., Belohradsky, B.H., Meindl, A. Eur. J. Hum. Genet. (2002) [Pubmed]
  17. Use of multiplex PCR to identify Staphylococcus aureus adhesins involved in human hematogenous infections. Tristan, A., Ying, L., Bes, M., Etienne, J., Vandenesch, F., Lina, G. J. Clin. Microbiol. (2003) [Pubmed]
  18. The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogenous osteomyelitis. Montes, A.H., Asensi, V., Alvarez, V., Valle, E., Ocaña, M.G., Meana, A., Carton, J.A., Paz, J., Fierer, J., Celada, A. Clin. Exp. Immunol. (2006) [Pubmed]
  19. Use of scintigraphy for assessment of fracture healing and early diagnosis of osteomyelitis following fracture repair in rabbits. Southwood, L.L., Kawcak, C.E., McIlwraith, C.W., Frisbie, D.D., Steyn, P.E. Am. J. Vet. Res. (2003) [Pubmed]
  20. Combined bone scintigraphy and indium-111 leukocyte scans in neuropathic foot disease. Schauwecker, D.S., Park, H.M., Burt, R.W., Mock, B.H., Wellman, H.N. J. Nucl. Med. (1988) [Pubmed]
  21. Enthesopathy of the patellar tendon insertion associated with isotretinoin therapy. Scuderi, A.J., Datz, F.L., Valdivia, S., Morton, K.A. J. Nucl. Med. (1993) [Pubmed]
  22. Osteomyelitis: diagnosis with (99m)Tc-labeled antigranulocyte antibodies compared with diagnosis with (111)In-labeled leukocytes--initial experience. Palestro, C.J., Kipper, S.L., Weiland, F.L., Love, C., Tomas, M.B. Radiology. (2002) [Pubmed]
  23. Regulation of monocyte chemokine and MMP-9 secretion by proinflammatory cytokines in tuberculous osteomyelitis. Wright, K.M., Friedland, J.S. J. Leukoc. Biol. (2004) [Pubmed]
  24. Cryptococcal osteomyelitis and cellular immunodeficiency associated with interleukin-2 deficiency. Sorensen, R.U., Boehm, K.D., Kaplan, D., Berger, M. J. Pediatr. (1992) [Pubmed]
  25. Differential regulation of chemokine secretion in tuberculous and staphylococcal osteomyelitis. Wright, K.M., Friedland, J.S. J. Bone Miner. Res. (2002) [Pubmed]
  26. Tumor necrosis factor-alpha, interleukin-6, and interleukin-8 secretion and the acute-phase response in patients with bacterial and tuberculous osteomyelitis. Evans, C.A., Jellis, J., Hughes, S.P., Remick, D.G., Friedland, J.S. J. Infect. Dis. (1998) [Pubmed]
  27. Human osteoclasts and osteoclast-like cells synthesize and release high basal and inflammatory stimulated levels of the potent chemokine interleukin-8. Rothe, L., Collin-Osdoby, P., Chen, Y., Sunyer, T., Chaudhary, L., Tsay, A., Goldring, S., Avioli, L., Osdoby, P. Endocrinology (1998) [Pubmed]
  28. Animal models of osteomyelitis. Mader, J.T. Am. J. Med. (1985) [Pubmed]
  29. Economic impact of oral ciprofloxacin. A pharmacist's perspective. Barriere, S.L. Am. J. Med. (1987) [Pubmed]
  30. Radionuclide diagnosis of vertebral osteomyelitis: indium-111-leukocyte and technetium-99m-methylene diphosphonate bone scintigraphy. Palestro, C.J., Kim, C.K., Swyer, A.J., Vallabhajosula, S., Goldsmith, S.J. J. Nucl. Med. (1991) [Pubmed]
  31. Treatment of fungal infections in the bones and joints with ketoconazole. Horsburgh, C.R., Cannady, P.B., Kirkpatrick, C.H. J. Infect. Dis. (1983) [Pubmed]
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