Disease relevance of Conidiobolus

• Entomophthoramycosis by Conidiobolus coronatus. Report of a case successfully treated with the combination of itraconazole and fluconazole [1].

High impact information on Conidiobolus

• 3. Half of the Basidiobolus isolates and all Conidiobolus isolates were inhibited by amphotericin B at 0.39 micrograms/ml [2].
• The protease ("N" state) from Conidiobolus macrosporus (NCIM 1298) unfolds at pH 2.0 ("U" state) through a partially unfolded "I" state at pH 3.5 that undergoes transition to a molten globule-(MG) like "I(A)" state in the presence of 0.5 M sodium sulfate [3].
• Kinetic analysis of the N-bromosuccinimide- (NBS) or p-hydroxymercuribenzoate- (PHMB) modified enzyme from Conidiobolus sp. revealed that a single Trp and Cys are essential for activity in addition to the Asp, His, and Ser residues of the catalytic triad [4].
• Desmosterol appeared to be the characteristic sterol of the Mortierellaceae (Mucorales), 24-Methyl cholesterol was the major sterol of the Entomophthorales genera Entomophthora, Conidiobolus and Basidiobolus, but cholesterol was the sole sterol detected in Delacroixia coronatus [5].
• A serine alkaline protease from the fungus Conidiobolus coronatus with a distinctly different structure than the serine protease subtilisin Carlsberg [6].

Associations of Conidiobolus with chemical compounds

• The Conidiobolus serine protease fails to obey the general rule that proteins with similar functions have similar primary sequences and, thus, are evolutionarily related [6].
• Conidiobolus coronatus infection treated with ketoconazole [7].
• We demonstrated the presence of lectins binding to glucose and N-acetylglucosamine on the surface of Conidiobolus obscurus spores by using glycosylated serum albumins substituted with fluorescent dyes and colloidal gold [8].
• A crack cocaine abuser developed disseminated infection caused by a species of Conidiobolus not known to cause disease in vertebrates [9].

Gene context of Conidiobolus

• The alkaline serine protease of Conidiobolus coronatus was shown to be involved in its conidial discharge [Phadatare, S., Srinivasan, M. C., Deshpande, M. (1989) Arch. Microbiol. 153, 47-49] [10].
• The occurrence of false positive results among sera obtained from patients with phycomycosis (zygomycosis) due to Mucor spp., Conidiobolus coronata and Pythium spp., and from patients with Penicillium marneffei infections, was not observed [11].

References