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MeSH Review:

Rhamnaceae

Ko, W.C. et al., Abdel-Zaher, A.O. et al., Giacomelli, S.R. et al., Dunstan, C. et al., Morel, A.F. et al., et al.

Abdel-Zaher, Salim, Assaf, Abdel-Hady, Ko, Wang, Lei, Shih, Chung, Lin, Morel, Araujo, da Silva, Hoelzel, Záchia, Bastos,

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Disease relevance of Rhamnaceae

We investigated the mechanisms of action of 3-O-methylquercetin (3-MQ), isolated from Rhamnus nakaharai (Hayata) Hayata (Rhamnaceae) which is used as a folk medicine for treating constipation, inflammation, tumors and asthma in Taiwan. The tension changes of tracheal segments were isometrically recorded on a polygraph [1].

High impact information on Rhamnaceae

The isolation and structure determination of cyclic peptide alkaloids, discarine-M and discarine-N, along with seven known cyclic peptide alkaloids, adouetine-Y', franganine, frangulanine, discarines-A, -B, -C, and -D from the root bark of Discaria americana are described [2].
The cyclopeptide alkaloid, named condaline-A, was isolated from the root bark of Condalia buxifolia Reissek (Rhamnaceae), along with the known compounds adouetine-Y', scutianine-B, and scutianine-C [3].
Alphitol, a phenolic substance from Alphitonia zizyphoides which inhibits prostaglandin biosynthesis in vitro [4].
The new phenolic compound, 3,5-dihydroxy-4-methoxy phenethyl alcohol, named alphitol, and betulinic acid were from the bark of Alphitonia zizyphoides [4].
Structure elucidation of three triterpenoid saponins from Alphitonia zizyphoides using 2D NMR techniques [5].

Associations of Rhamnaceae with chemical compounds

Hepatoprotective effects of emodin from Ventilago leiocarpa [6].
The effect of the butanol extract of Zizyphus spina-christi (L.), Willd (Rhamnaceae) leaves and its major saponin glycoside, christinin-A, on the serum glucose and insulin levels was studied in non-diabetic control, type-I (insulin-dependent) and type-II (non-insulin-dependent) diabetic rats [7].

References

Mechanisms of relaxant action of 3-O-methylquercetin in isolated guinea pig trachea. Ko, W.C., Wang, H.L., Lei, C.B., Shih, C.H., Chung, M.I., Lin, C.N. Planta Med. (2002) [Pubmed]
Cyclic peptide alkaloids from the bark of Discaria americana. Giacomelli, S.R., Maldaner, G., Gonzaga, W.A., Garcia, C.M., da Silva, U.F., Dalcol, I.I., Morel, A.F. Phytochemistry (2004) [Pubmed]
Antibacterial cyclopeptide alkaloids from the bark of Condalia buxifolia. Morel, A.F., Araujo, C.A., da Silva, U.F., Hoelzel, S.C., Záchia, R., Bastos, N.R. Phytochemistry (2002) [Pubmed]
Alphitol, a phenolic substance from Alphitonia zizyphoides which inhibits prostaglandin biosynthesis in vitro. Dunstan, C., Liu, B., Welch, C.J., Perera, P., Bohlin, L. Phytochemistry (1998) [Pubmed]
Structure elucidation of three triterpenoid saponins from Alphitonia zizyphoides using 2D NMR techniques. Li, D., Owen, N.L., Perera, P., Andersson, C., Bohlin, L., Cox, P.A., Pugmire, R.J., Mayne, C.L., Grant, D.M. J. Nat. Prod. (1994) [Pubmed]
Hepatoprotective effects of emodin from Ventilago leiocarpa. Lin, C.C., Chang, C.H., Yang, J.J., Namba, T., Hattori, M. Journal of ethnopharmacology. (1996) [Pubmed]
Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. Abdel-Zaher, A.O., Salim, S.Y., Assaf, M.H., Abdel-Hady, R.H. Journal of ethnopharmacology. (2005) [Pubmed]

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