Disease relevance of Aralia

• Rat lenses in media containing 20 mM xylose developed a distinctly opaque ring in 9h, and treatment with Aralia extract at a concentration of 1mg/ml lowered lens opacity by 36.4 and 31.3% after 24 and 48 h, respectively [1].
• The diabetic control animals developed cataracts at 11 weeks after STZ injection, while oral Aralia extract administered at 300 and 600 mg/kg body weight for 11 weeks reduced cataract formation by 15 and 12%, respectively [1].

High impact information on Aralia

• Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana [2].
• A new triterpenoid saponin, together with five known saponins, were isolated from the nonpolar n-hexane fraction of the leaves of Aralia elata [3].
• A novel triterpene saponin (1) was isolated from an ethanol extract of the root bark of Aralia dasyphylla [4].
• Bioactive saponins and glycosides. VII. On the hypoglycemic principles from the root cortex of Aralia elata Seem.: structure related hypoglycemic activity of oleanolic acid oligoglycoside [5].
• The hypoglycemic component, elatoside E, was isolated from the root cortex of Aralia elata SEEM [5].

Biological context of Aralia

• Elatosides A and B, potent inhibitors of ethanol absorption in rats from the bark of Aralia elata Seem: the structure-activity relationships of oleanolic acid oligoglycosides [6].
• The resulting IC50 value of Aralia extract in vitro as an aldose reductase inhibitor was 11.3 microg/ml and as an antioxidant was 25.1 microg/ml [1].

Anatomical context of Aralia

• Effects of saponins from the root bark of Aralia elata on the transport of chondroitin sulfate in Caco-2 cell monolayers and rats [7].

Associations of Aralia with chemical compounds

• Oleanolic acid saponins from root bark of Aralia elata [8].
• Triterpenoid saponins from the roots of Aralia spinifolia [9].
• A new inhibitor named elatosides E (which was shown to affect the elevation of plasma glucose level by oral sugar tolerance test in rats) was isolated from the root cortex of Aralia elata Seem. together with elatoside F [10].
• Three new oleanolic acid glycosides, tarasaponins I-III, were isolated as their methyl esters from the root bark of Aralia elata together with four known glycosides, the methyl esters of chikusetsusaponins IVa, IV, 28-desglucosyl-chikusetsusaponin IV and pseudoginsenoside RT1 [8].
• Purification and partial sequences of Aralia cordata cinnamyl alcohol dehydrogenase [11].

Gene context of Aralia

• Here, we investigated the aldose reductase inhibitory activity, antioxidant activity and anticataract capacity of Aralia extract using various experimental systems [1].
• Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells [12].

References