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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Gene Components

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Disease relevance of Gene Components


High impact information on Gene Components


Anatomical context of Gene Components


Associations of Gene Components with chemical compounds


Gene context of Gene Components

  • Genetic evidence for interaction between components of the yeast 26S proteasome: combination of a mutation in RPN12 (a lid component gene) with mutations in RPT1 (an ATPase gene) causes synthetic lethality [9].
  • Despite the large number of cancer types now characterized for telomerase or telomerase component gene expression, only a handful of SCLC samples have been analysed [10].
  • These data indicate that the bymovirus RNA1 fits the consensus potyviral genetic map downstream of the helper component gene [11].
  • Loss of E-cadherin or its catenin partners of cellular adhesion will result in increasing invasiveness and metastatic potential of neoplastic cells but, because of several alternative routes to the same effect, incidence of lost expression for one component gene like E-cadherin does not need to be very high [12].
  • Segregation analysis of rheumatoid arthritis alone revealed that the mixed model, including both polygenic and major gene components, was the most parsimonious [13].

Analytical, diagnostic and therapeutic context of Gene Components

  • The presence of the gene components encoding production of enterotoxins Nhe, Hbl, EntT and a recently described cytotoxin K was determined by PCR [14].


  1. Ki-ras point mutation and p53 expression in human pancreatic cancer: a comparative study among Chinese, Japanese, and Western patients. Dong, M., Nio, Y., Tamura, K., Song, M.M., Guo, K.J., Guo, R.X., Dong, Y.T. Cancer Epidemiol. Biomarkers Prev. (2000) [Pubmed]
  2. Transactivation of geminivirus AR1 and BR1 gene expression by the viral AL2 gene product occurs at the level of transcription. Sunter, G., Bisaro, D.M. Plant Cell (1992) [Pubmed]
  3. Interaction of the iron-sulfur cluster assembly protein IscU with the Hsc66/Hsc20 molecular chaperone system of Escherichia coli. Hoff, K.G., Silberg, J.J., Vickery, L.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Androgen specificity of a response unit upstream of the human secretory component gene is mediated by differential receptor binding to an essential androgen response element. Verrijdt, G., Schoenmakers, E., Alen, P., Haelens, A., Peeters, B., Rombauts, W., Claessens, F. Mol. Endocrinol. (1999) [Pubmed]
  5. Lifelong angiotensin-converting enzyme inhibition, pressure natriuresis, and renin-angiotensin system gene expression in transgenic (mRen-2)27 rats. Lippoldt, A., Gross, V., Bohlender, J., Ganten, U., Luft, F.C. J. Am. Soc. Nephrol. (1996) [Pubmed]
  6. Androgen-receptor-specific DNA binding to an element in the first exon of the human secretory component gene. Haelens, A., Verrijdt, G., Callewaert, L., Peeters, B., Rombauts, W., Claessens, F. Biochem. J. (2001) [Pubmed]
  7. Interleukin-4 and interferon-gamma synergistically increase secretory component gene expression, but are additive in stimulating secretory immunoglobulin A release by Calu-3 airway epithelial cells. Loman, S., Jansen, H.M., Out, T.A., Lutter, R. Immunology (1999) [Pubmed]
  8. Mutations in genes involved in the flagellar export apparatus of the solvent-tolerant Pseudomonas putida DOT-T1E strain impair motility and lead to hypersensitivity to toluene shocks. Segura, A., Duque, E., Hurtado, A., Ramos, J.L. J. Bacteriol. (2001) [Pubmed]
  9. Genetic evidence for interaction between components of the yeast 26S proteasome: combination of a mutation in RPN12 (a lid component gene) with mutations in RPT1 (an ATPase gene) causes synthetic lethality. Takeuchi, J., Toh-e, A. Mol. Gen. Genet. (1999) [Pubmed]
  10. Is small cell lung cancer the perfect target for anti-telomerase treatment? Sarvesvaran, J., Going, J.J., Milroy, R., Kaye, S.B., Keith, W.N. Carcinogenesis (1999) [Pubmed]
  11. The complete nucleotide sequence of barley mild mosaic virus RNA1 and its relationship with other members of the Potyviridae. Meyer, M., Dessens, J.T. Virology (1996) [Pubmed]
  12. Methylation of tumor suppressor genes p16(INK4a), p27(Kip1) and E-cadherin in carcinogenesis. Auerkari, E.I. Oral Oncol. (2006) [Pubmed]
  13. Familial clustering of rheumatoid arthritis with other autoimmune diseases. Lin, J.P., Cash, J.M., Doyle, S.Z., Peden, S., Kanik, K., Amos, C.I., Bale, S.J., Wilder, R.L. Hum. Genet. (1998) [Pubmed]
  14. Psychrotolerant species from the Bacillus cereus group are not necessarily Bacillus weihenstephanensis. Stenfors, L.P., Granum, P.E. FEMS Microbiol. Lett. (2001) [Pubmed]
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