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MeSH Review:

Laurus

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Disease relevance of Laurus

The possible antiulcerogenic activity of Laurus nobilis seeds was tested on experimentally (ethanol) induced gastric ulcer in rats [1].

High impact information on Laurus

Sesquiterpenes (costunolide and zaluzanin D) were purified from laurel (Laurus nobilis L.) and identified by Mass, and 1H- and 13C-NMR [2].
Extraction and chromatographic conditions for measuring tocopherols from Laurus nobilis were optimized [3].
Optimized and validated HPLC method for alpha- and gamma-tocopherol measurement in Laurus nobilis leaves. New data on tocopherol content [3].
The methanolic extract from the leaves of Laurus nobilis (bay leaf, laurel) was found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated mouse peritoneal macrophages [4].
Preventive effect of sesquiterpenes from bay leaf on blood ethanol elevation in ethanol-loaded rat: structure requirement and suppression of gastric emptying [5].

Biological context of Laurus

Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion [6].

Associations of Laurus with chemical compounds

Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures [7].
Significant changes due to the irradiation occurred only in (+/-)-linalool and alpha-terpineol, which are typical components of, for example, coriander and bay leaf [8].
Almost complete inhibition of 3-nitrotyrosine formation (91% at 300 microg/ml) was achieved only with the essential oil obtained from the leaves of Laurus nobilis [9].
The antifungal activity of Aniba rosaeodora, Laurus nobilis, Sassafras albidum and Cinnamomum zeylanicum essential oils were investigated against 17 micromycetes [10].

Gene context of Laurus

Evaluation of the gastroprotective effect of Laurus nobilis seeds on ethanol induced gastric ulcer in rats [1].

References

Evaluation of the gastroprotective effect of Laurus nobilis seeds on ethanol induced gastric ulcer in rats. Afifi, F.U., Khalil, E., Tamimi, S.O., Disi, A. Journal of ethnopharmacology. (1997) [Pubmed]
Sesquiterpenes (costunolide and zaluzanin D) isolated from laurel (Laurus nobilis L.) induce cell death and morphological change indicative of apoptotic chromatin condensation in leukemia HL-60 cells. Hibasami, H., Yamada, Y., Moteki, H., Katsuzaki, H., Imai, K., Yoshioka, K., Komiya, T. Int. J. Mol. Med. (2003) [Pubmed]
Optimized and validated HPLC method for alpha- and gamma-tocopherol measurement in Laurus nobilis leaves. New data on tocopherol content. Gómez-Coronado, D.J., Barbas, C. J. Agric. Food Chem. (2003) [Pubmed]
Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: structure requirement and role of heat shock protein induction. Matsuda, H., Kagerura, T., Toguchida, I., Ueda, H., Morikawa, T., Yoshikawa, M. Life Sci. (2000) [Pubmed]
Preventive effect of sesquiterpenes from bay leaf on blood ethanol elevation in ethanol-loaded rat: structure requirement and suppression of gastric emptying. Matsuda, H., Shimoda, H., Uemura, T., Yoshikawa, M. Bioorg. Med. Chem. Lett. (1999) [Pubmed]
Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion. Matsuda, H., Shimoda, H., Ninomiya, K., Yoshikawa, M. Alcohol Alcohol. (2002) [Pubmed]
Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures. Sayyah, M., Valizadeh, J., Kamalinejad, M. Phytomedicine (2002) [Pubmed]
The effects of gamma-irradiation on some pure aroma compounds of spices. Sjövall, O., Honkanen, E., Kallio, H., Latva-Kala, K., Sjöberg, A.M. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. (1990) [Pubmed]
Essential oils of commonly used plants as inhibitors of peroxynitrite-induced tyrosine nitration. Chericoni, S., Prieto, J.M., Iacopini, P., Morelli, I. Fitoterapia (2005) [Pubmed]
The chemical composition of some Lauraceae essential oils and their antifungal activities. Simić, A., Soković, M.D., Ristić, M., Grujić-Jovanović, S., Vukojević, J., Marin, P.D. Phytotherapy research : PTR. (2004) [Pubmed]

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