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Chemical Compound Review

Nitrotyrosine     (2S)-2-amino-3-(4-hydroxy-3- nitro...

Synonyms: PubChem11983, SureCN38175, CCRIS 3566, AG-F-25384, CHEBI:44454, ...
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Disease relevance of L-3-Nitrotyrosine


Psychiatry related information on L-3-Nitrotyrosine


High impact information on L-3-Nitrotyrosine


Chemical compound and disease context of L-3-Nitrotyrosine


Biological context of L-3-Nitrotyrosine


Anatomical context of L-3-Nitrotyrosine


Associations of L-3-Nitrotyrosine with other chemical compounds


Gene context of L-3-Nitrotyrosine


Analytical, diagnostic and therapeutic context of L-3-Nitrotyrosine


  1. Myeloperoxidase produces nitrating oxidants in vivo. Gaut, J.P., Byun, J., Tran, H.D., Lauber, W.M., Carroll, J.A., Hotchkiss, R.S., Belaaouaj, A., Heinecke, J.W. J. Clin. Invest. (2002) [Pubmed]
  2. Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. Jaiswal, M., LaRusso, N.F., Shapiro, R.A., Billiar, T.R., Gores, G.J. Gastroenterology (2001) [Pubmed]
  3. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Beal, M.F., Ferrante, R.J., Browne, S.E., Matthews, R.T., Kowall, N.W., Brown, R.H. Ann. Neurol. (1997) [Pubmed]
  4. Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species. Pennathur, S., Bergt, C., Shao, B., Byun, J., Kassim, S.Y., Singh, P., Green, P.S., McDonald, T.O., Brunzell, J., Chait, A., Oram, J.F., O'brien, K., Geary, R.L., Heinecke, J.W. J. Biol. Chem. (2004) [Pubmed]
  5. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. Hensley, K., Maidt, M.L., Yu, Z., Sang, H., Markesbery, W.R., Floyd, R.A. J. Neurosci. (1998) [Pubmed]
  6. NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease. Galpern, W.R., Matthews, R.T., Beal, M.F., Isacson, O. Neuroreport (1996) [Pubmed]
  7. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. Eberhardt, R.T., Forgione, M.A., Cap, A., Leopold, J.A., Rudd, M.A., Trolliet, M., Heydrick, S., Stark, R., Klings, E.S., Moldovan, N.I., Yaghoubi, M., Goldschmidt-Clermont, P.J., Farber, H.W., Cohen, R., Loscalzo, J. J. Clin. Invest. (2000) [Pubmed]
  8. Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. McKim, S.E., Gäbele, E., Isayama, F., Lambert, J.C., Tucker, L.M., Wheeler, M.D., Connor, H.D., Mason, R.P., Doll, M.A., Hein, D.W., Arteel, G.E. Gastroenterology (2003) [Pubmed]
  9. Nitric oxide, oxidants, and protein tyrosine nitration. Radi, R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  10. Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease. Pennathur, S., Jackson-Lewis, V., Przedborski, S., Heinecke, J.W. J. Biol. Chem. (1999) [Pubmed]
  11. Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerates sarcoma development in Trp53+/- mice. Tazawa, H., Tatemichi, M., Sawa, T., Gilibert, I., Ma, N., Hiraku, Y., Donehower, L.A., Ohgaki, H., Kawanishi, S., Ohshima, H. Carcinogenesis (2007) [Pubmed]
  12. In vivo formation of diiodotyrosine by extrathyroidal thyroxine ether-link cleavage and effects of mononitrotyrosine on this pathway in the rat. Meinhold, H., Buchholz, R. Endocrinology (1986) [Pubmed]
  13. Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury. Hall, E.D., Detloff, M.R., Johnson, K., Kupina, N.C. J. Neurotrauma (2004) [Pubmed]
  14. The mechanisms for nitration and nitrotyrosine formation in vitro and in vivo: impact of diet. Oldreive, C., Rice-Evans, C. Free Radic. Res. (2001) [Pubmed]
  15. Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity. Meldal, M., Svendsen, I., Breddam, K., Auzanneau, F.I. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Lu, Y., Cederbaum, A.I. Hepatology (2006) [Pubmed]
  17. Nitrotyrosine formation, apoptosis, and oxidative damage: relationships to nitric oxide production in SJL mice bearing the RcsX tumor. Gal, A., Tamir, S., Kennedy, L.J., Tannenbaum, S.R., Wogan, G.N. Cancer Res. (1997) [Pubmed]
  18. Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite. Implications for tyrosine modification by nitric oxide/superoxide in vivo. Pfeiffer, S., Schmidt, K., Mayer, B. J. Biol. Chem. (2000) [Pubmed]
  19. Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase. Schmidt, P., Youhnovski, N., Daiber, A., Balan, A., Arsic, M., Bachschmid, M., Przybylski, M., Ullrich, V. J. Biol. Chem. (2003) [Pubmed]
  20. Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection. Shigenaga, M.K., Lee, H.H., Blount, B.C., Christen, S., Shigeno, E.T., Yip, H., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  21. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Bruijn, L.I., Beal, M.F., Becher, M.W., Schulz, J.B., Wong, P.C., Price, D.L., Cleveland, D.W. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  22. Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis. Tohgi, H., Abe, T., Yamazaki, K., Murata, T., Ishizaki, E., Isobe, C. Ann. Neurol. (1999) [Pubmed]
  23. Myeloperoxidase-positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide-mediated reactions. Wu, C.T., Eiserich, J.P., Ansari, A.A., Coppel, R.L., Balasubramanian, S., Bowlus, C.L., Gershwin, M.E., Van De Water, J. Hepatology (2003) [Pubmed]
  24. Endothelial dysfunction and peroxynitrite formation are early events in angiotensin-induced cardiovascular disorders. Wattanapitayakul, S.K., Weinstein, D.M., Holycross, B.J., Bauer, J.A. FASEB J. (2000) [Pubmed]
  25. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. Yang, L., Matthews, R.T., Schulz, J.B., Klockgether, T., Liao, A.W., Martinou, J.C., Penney, J.B., Hyman, B.T., Beal, M.F. J. Neurosci. (1998) [Pubmed]
  26. Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase. Kessova, I.G., Ho, Y.S., Thung, S., Cederbaum, A.I. Hepatology (2003) [Pubmed]
  27. Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury. Song, Y., Wang, J., Li, Y., Du, Y., Arteel, G.E., Saari, J.T., Kang, Y.J., Cai, L. Am. J. Pathol. (2005) [Pubmed]
  28. Superoxide fluxes limit nitric oxide-induced signaling. Thomas, D.D., Ridnour, L.A., Espey, M.G., Donzelli, S., Ambs, S., Hussain, S.P., Harris, C.C., DeGraff, W., Roberts, D.D., Mitchell, J.B., Wink, D.A. J. Biol. Chem. (2006) [Pubmed]
  29. Inducible nitric oxide synthase mediates prostaglandin h2 synthase nitration and suppresses eicosanoid production. Deeb, R.S., Shen, H., Gamss, C., Gavrilova, T., Summers, B.D., Kraemer, R., Hao, G., Gross, S.S., Lainé, M., Maeda, N., Hajjar, D.P., Upmacis, R.K. Am. J. Pathol. (2006) [Pubmed]
  30. Nitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary disease. Barreiro, E., Gea, J., Corominas, J.M., Hussain, S.N. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  31. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease. Mohmmad Abdul, H., Sultana, R., Keller, J.N., St Clair, D.K., Markesbery, W.R., Butterfield, D.A. J. Neurochem. (2006) [Pubmed]
  32. Diffusion of peroxynitrite into the human platelet inhibits cyclooxygenase via nitration of tyrosine residues. Boulos, C., Jiang, H., Balazy, M. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  33. Lack of tyrosine nitration by hypochlorous acid in the presence of physiological concentrations of nitrite. Implications for the role of nitryl chloride in tyrosine nitration in vivo. Whiteman, M., Siau, J.L., Halliwell, B. J. Biol. Chem. (2003) [Pubmed]
  34. Lack of tyrosine nitration by peroxynitrite generated at physiological pH. Pfeiffer, S., Mayer, B. J. Biol. Chem. (1998) [Pubmed]
  35. Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry. Kanski, J., Hong, S.J., Schöneich, C. J. Biol. Chem. (2005) [Pubmed]
  36. Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase. Nam, K.T., Oh, S.Y., Ahn, B., Kim, Y.B., Jang, D.D., Yang, K.H., Hahm, K.B., Kim, D.Y. Gut (2004) [Pubmed]
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