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MeSH Review

Platycodon

 
 
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Disease relevance of Platycodon

 

High impact information on Platycodon

  • A novel triterpenoid saponin, deapioplatycoside E (1) was isolated from the root extract of Platycodon grandiflorum, together with the seven known saponins 2 - 8, i. e., platycoside E (2), deapioplatycodin D3 (3), platycodin D3 (4), polygalacin D2 (5), platycodin D2 (6), deapioplatycodin D (7) and platycodin D (8) [2].
  • In this study, we investigated the effect of platycodin D and D3, the saponin components that are anti-inflammatory components in Platycodon grandiflorum [3].
  • Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells [4].
  • Antioxidant activity of phenylpropanoid esters isolated and identified from Platycodon grandiflorum A. DC [5].
  • Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity [6].
 

Associations of Platycodon with chemical compounds

  • Platycodin D, isolated from the root of Platycodon grandiflorum A [7].
  • The sulfite content in the simulated Platycodon radix sample determined by alkali extraction followed by ion-exclusion chromatography with electrochemical detection (AOAC 990.31) was approximately 17% lower on average than the MW results [8].
  • Although there was no statistical significance, the crude glucose transporter 4 protein level of obese rats fed Platycodon grandiflorum tended to increase when compared with that of obese control rats [9].
  • Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice [10].
  • Dietary Platycodon grandiflorum feeding for 4 weeks resulted in a significant decrease in the concentration of plasma triglyceride in both lean and obese Zucker rats [9].
 

Gene context of Platycodon

 

Analytical, diagnostic and therapeutic context of Platycodon

References

  1. Suppressive effects of Platycodon grandiflorum on the progress of carbon tetrachloride-induced hepatic fibrosis. Lee, K.J., Kim, J.Y., Jung, K.S., Choi, C.Y., Chung, Y.C., Kim, D.H., Jeong, H.G. Arch. Pharm. Res. (2004) [Pubmed]
  2. Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines. Kim, Y.S., Kim, J.S., Choi, S.U., Kim, J.S., Lee, H.S., Roh, S.H., Jeong, Y.C., Kim, Y.K., Ryu, S.Y. Planta Med. (2005) [Pubmed]
  3. Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters. Shin, C.Y., Lee, W.J., Lee, E.B., Choi, E.Y., Ko, K.H. Planta Med. (2002) [Pubmed]
  4. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Ahn, K.S., Noh, E.J., Zhao, H.L., Jung, S.H., Kang, S.S., Kim, Y.S. Life Sci. (2005) [Pubmed]
  5. Antioxidant activity of phenylpropanoid esters isolated and identified from Platycodon grandiflorum A. DC. Lee, J.Y., Yoon, J.W., Kim, C.T., Lim, S.T. Phytochemistry (2004) [Pubmed]
  6. Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity. Lee, K.J., Choi, C.Y., Chung, Y.C., Kim, Y.S., Ryu, S.Y., Roh, S.H., Jeong, H.G. Toxicol. Lett. (2004) [Pubmed]
  7. Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum. Kim, Y.P., Lee, E.B., Kim, S.Y., Li, D., Ban, H.S., Lim, S.S., Shin, K.H., Ohuchi, K. Planta Med. (2001) [Pubmed]
  8. Determination of sulfite in Oriental herbal medicines. Kim, Y.K., Koh, E., Park, S.Y., Chang, S.Y., Park, S.J., Na, W.I., Kim, H.J. Journal of AOAC International. (2000) [Pubmed]
  9. Effect of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats. Kim, K.S., Seo, E.K., Lee, Y.C., Lee, T.K., Cho, Y.W., Ezaki, O., Kim, C.H. J. Nutr. Biochem. (2000) [Pubmed]
  10. Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice. Lee, K.J., You, H.J., Park, S.J., Kim, Y.S., Chung, Y.C., Jeong, T.C., Jeong, H.G. Cancer Lett. (2001) [Pubmed]
  11. Activation of mitogen-activated protein kinases and AP-1 by polysaccharide isolated from the radix of Platycodon grandiflorum in RAW 264.7 cells. Yoon, Y.D., Kang, J.S., Han, S.B., Park, S.K., Lee, H.S., Kang, J.S., Kim, H.M. Int. Immunopharmacol. (2004) [Pubmed]
  12. Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells. Wang, C., Schuller Levis, G.B., Lee, E.B., Levis, W.R., Lee, d.a. .W., Kim, B.S., Park, S.Y., Park, E. Int. Immunopharmacol. (2004) [Pubmed]
  13. Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells. Han, S.B., Park, S.H., Lee, K.H., Lee, C.W., Lee, S.H., Kim, H.C., Kim, Y.S., Lee, H.S., Kim, H.M. Int. Immunopharmacol. (2001) [Pubmed]
 
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