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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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High impact information on Combretum


Biological context of Combretum

  • Hepatoprotective effect of MeOH, MeOH-H2O (1:1) and H2O extracts of Combretum quadrangulare seeds were examined on D-galactosamine (D-GalN)/tumor necrosis factor-alpha(TNF-alpha)-induced cell death in primary cultured mouse hepatocytes [6].

Anatomical context of Combretum


Associations of Combretum with chemical compounds

  • This explains the well-known difference in emulsification functionality between gum arabic, in which all rhamnose and uronic acid groups chain-terminal, and gum combretum which is, in addition, markedly hygroscopic and characterized commercially by its tendency to 'block' in transit and storage [5].
  • The lowest IC(50) value was 0.04 mg ml(-1) obtained with an ethanol bark extract of Combretum kraussii [8].
  • Extracts of different parts of Combretum hartmannianum (Combretaceae) possessed significant activity against the chloroquine-sensitive P. falciparum strain (NF54) with IC(50) values of 0.2 microg/ml (bark), 0.4 microg/ml (stem) and 4.3 microg/ml (leaves) [9].

Gene context of Combretum

  • None of the tested extracts except the acetone fraction obtained from the stem bark of Combretum molle (R. Br. ex G. Don.) Engl & Diels (Combretaceae) showed significant inhibitory action against this strain [10].


  1. 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-beta-D-glucose, a new hepatoprotective constituent from Combretum quadrangulare. Adnyana, I.K., Tezuka, Y., Awale, S., Banskota, A.H., Tran, K.Q., Kadota, S. Planta Med. (2001) [Pubmed]
  2. Cyclobutanes from Combretum albopunctatum. Katerere, D.R., Gray, A.I., Kennedy, A.R., Nash, R.J., Waigh, R.D. Phytochemistry (2004) [Pubmed]
  3. Bioactive compounds from Combretum erythrophyllum. Schwikkard, S., Zhou, B.N., Glass, T.E., Sharp, J.L., Mattern, M.R., Johnson, R.K., Kingston, D.G. J. Nat. Prod. (2000) [Pubmed]
  4. Methyl quadrangularates A-D and related triterpenes from Combretum quadrangulare. Banskota, A.H., Tezuka, Y., Tran, K.Q., Tanaka, K., Saiki, I., Kadota, S. Chem. Pharm. Bull. (2000) [Pubmed]
  5. The gum exudate from Combretum nigricans gum, the major source of West African 'gum combretum'. Anderson, D.M., Millar, J.R., Weiping, W. Food additives and contaminants. (1991) [Pubmed]
  6. Hepatoprotective constituents of the seeds of Combretum quadrangulare. Adnyana, I.K., Tezuka, Y., Banskota, A.H., Tran, K.Q., Kadot, S. Biol. Pharm. Bull. (2000) [Pubmed]
  7. Composition of the gum from Combretum paniculatum and four other gums which are not permitted food additives. Anderson, D.M., Wang, W.P. Phytochemistry (1990) [Pubmed]
  8. Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine. Eldeen, I.M., Elgorashi, E.E., van Staden, J. Journal of ethnopharmacology. (2005) [Pubmed]
  9. Evaluation of selected Sudanese medicinal plants for their in vitro activity against hemoflagellates, selected bacteria, HIV-1-RT and tyrosine kinase inhibitory, and for cytotoxicity. Ali, H., König, G.M., Khalid, S.A., Wright, A.D., Kaminsky, R. Journal of ethnopharmacology. (2002) [Pubmed]
  10. Investigations on antimycobacterial activity of some Ethiopian medicinal plants. Asres, K., Bucar, F., Edelsbrunner, S., Kartnig, T., Höger, G., Thiel, W. Phytotherapy research : PTR. (2001) [Pubmed]
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