High impact information on Combretum

• A new gallic acid derivative, 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-beta-D-glucose (1) has been isolated from an H2O-fraction of MeOH extract of Combretum quadrangulare seeds [1].
• A dichloromethane extract of the aerial parts of Combretum albopunctatum Suesseng afforded five phenolic compounds-three known flavonoids and two novel cyclobutane chalcone dimers [2].
• A methanol extract of Combretum erythrophyllum showed inhibitory bioactivities in a yeast-based microtiter assay for DNA-damaging agents [3].
• Methyl quadrangularates A-D and related triterpenes from Combretum quadrangulare [4].
• NMR spectroscopy has also shown that the rhamnose and uronic acid contents of gum combretum are located within internal polysaccharide chains [5].

Biological context of Combretum

• Hepatoprotective effect of MeOH, MeOH-H2O (1:1) and H2O extracts of Combretum quadrangulare seeds were examined on D-galactosamine (D-GalN)/tumor necrosis factor-alpha(TNF-alpha)-induced cell death in primary cultured mouse hepatocytes [6].

Anatomical context of Combretum

• This paper presents analytical data for the gum exudates from Atalaya hemiglauca, Cassine aethiopica, Combretum paniculatum, Sclerocarya birrea, and Pseudocedrela kotschyi [7].

Associations of Combretum with chemical compounds

• This explains the well-known difference in emulsification functionality between gum arabic, in which all rhamnose and uronic acid groups chain-terminal, and gum combretum which is, in addition, markedly hygroscopic and characterized commercially by its tendency to 'block' in transit and storage [5].
• The lowest IC(50) value was 0.04 mg ml(-1) obtained with an ethanol bark extract of Combretum kraussii [8].
• Extracts of different parts of Combretum hartmannianum (Combretaceae) possessed significant activity against the chloroquine-sensitive P. falciparum strain (NF54) with IC(50) values of 0.2 microg/ml (bark), 0.4 microg/ml (stem) and 4.3 microg/ml (leaves) [9].

Gene context of Combretum

• None of the tested extracts except the acetone fraction obtained from the stem bark of Combretum molle (R. Br. ex G. Don.) Engl & Diels (Combretaceae) showed significant inhibitory action against this strain [10].

References