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Disease relevance of Zanthoxylum

  • OBJECTIVE: To define the nature and mechanisms of neuromuscular effects of toxic principles in bark of Southern Prickly Ash tree (Zanthoxylum clava-herculis) that might contribute to its clinical toxicity in cattle [1].
  • In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug ef flux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis [2].

High impact information on Zanthoxylum


Biological context of Zanthoxylum


Associations of Zanthoxylum with chemical compounds

  • The most abundant classes of compounds found in Zanthoxylum leaf oils are acyclic and menthane monoterpenoids as well as simple alcohols, aldehydes, and ketones [3].
  • Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium [8].
  • Anthelmintic properties of alpha-sanshool from Zanthoxylum liebmannianum [9].
  • Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolated as new natural products from the stem barks of Zanthoxylum hyemale, together with seven known compounds [10].
  • Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids, 1-hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae) [11].

Gene context of Zanthoxylum


  1. Neuromuscular effects of toxins isolated from southern prickly ash (Zanthoxylum clava-herculis) bark. Bowen, J.M., Cole, R.J., Bedell, D., Schabdach, D. Am. J. Vet. Res. (1996) [Pubmed]
  2. Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA). Gibbons, S., Leimkugel, J., Oluwatuyi, M., Heinrich, M. Phytotherapy research : PTR. (2003) [Pubmed]
  3. Leaf essential oil composition of five Zanthoxylum species from Monteverde, Costa Rica. Setzer, W.N., Noletto, J.A., Lawton, R.O., Haber, W.A. Mol. Divers. (2005) [Pubmed]
  4. Soil moisture redistribution as a mechanism of facilitation in savanna tree-shrub clusters. Zou, C.B., Barnes, P.W., Archer, S., McMurtry, C.R. Oecologia (2005) [Pubmed]
  5. Monoamine oxidase inhibitory coumarin from Zanthoxylum schinifolium. Jo, Y.S., Huong, D.T., Bae, K., Lee, M.K., Kim, Y.H. Planta Med. (2002) [Pubmed]
  6. Effect of methanol extract of Zanthoxylum piperitum leaves and of its compound, protocatechuic acid, on hepatic drug metabolizing enzymes and lipid peroxidation in rats. Hur, J.M., Park, J.G., Yang, K.H., Park, J.C., Park, J.R., Chun, S.S., Choi, J.S., Choi, J.W. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
  7. The essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen species. Paik, S.Y., Koh, K.H., Beak, S.M., Paek, S.H., Kim, J.A. Biol. Pharm. Bull. (2005) [Pubmed]
  8. Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium. Tsai, I.L., Lin, W.Y., Teng, C.M., Ishikawa, T., Doong, S.L., Huang, M.W., Chen, Y.C., Chen, I.S. Planta Med. (2000) [Pubmed]
  9. Anthelmintic properties of alpha-sanshool from Zanthoxylum liebmannianum. Navarrete, A., Hong, E. Planta Med. (1996) [Pubmed]
  10. Alkaloids, amides and antispasmodic activity of Zanthoxylum hyemale. de Moura, N.F., Morel, A.F., Dessoy, E.C., Zanatta, N., Bürger, M.M., Ahlert, N., Porto, G.P., Baldisserotto, B. Planta Med. (2002) [Pubmed]
  11. Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. Sheen, W.S., Tsai, I.L., Teng, C.M., Ko, F.N., Chen, I.S. Planta Med. (1996) [Pubmed]
  12. Tyrosinase inhibitor isolated from the leaves of Zanthoxylum piperitum. Jeong, C.H., Shim, K.H. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
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