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Gene Review

NAB1  -  NGFI-A binding protein 1 (EGR1 binding...

Homo sapiens

Synonyms: EGR-1-binding protein 1, NGFI-A-binding protein 1, Transcriptional regulatory protein p54
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Disease relevance of NAB1


High impact information on NAB1

  • This NGFI-A-binding protein, NAB1, is a 570-aa nuclear protein that bears no obvious sequence homology to known proteins [3].
  • Overexpression of Egr-2 and Egr-3 induced endogenous ligand upregulation that was inhibited by overexpression of Egr-specific inhibitor Nab1 [4].
  • The human NAB1 genomic locus was mapped to chromosome 2q32.3-33 [5].
  • Replacement mutagenesis of residues conserved between these proteins interfered with Nab1 repression, although Nab1 does not function by the same mechanism as Dr1 [5].
  • We have isolated and characterized another corepressor, NAB2, which is highly related to NAB1 within two discrete domains [6].

Biological context of NAB1


Anatomical context of NAB1


Physical interactions of NAB1

  • Therefore, we hypothesized that mutations in the EGR2-interacting domains of NAB1 and NAB2 might be associated with the pathogenesis of inherited peripheral neuropathies in currently unexplained cases [1].
  • Thus, the biological function of the inhibitory domain of Egr-1 is solely to provide a docking site for NAB1 via protein-protein interaction [8].

Other interactions of NAB1

  • Overexpression studies revealed that NAB1 is able to completely block transcription mediated by Egr-1 [8].


  1. Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. Venken, K., Di Maria, E., Bellone, E., Balestra, P., Cassandrini, D., Mandich, P., De Jonghe, P., Timmerman, V., Svaren, J. Neurogenetics (2002) [Pubmed]
  2. Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. Qiu, F.H., Devchand, P.R., Wada, K., Serhan, C.N. FASEB J. (2001) [Pubmed]
  3. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Russo, M.W., Sevetson, B.R., Milbrandt, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses. Droin, N.M., Pinkoski, M.J., Dejardin, E., Green, D.R. Mol. Cell. Biol. (2003) [Pubmed]
  5. Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. Swirnoff, A.H., Apel, E.D., Svaren, J., Sevetson, B.R., Zimonjic, D.B., Popescu, N.C., Milbrandt, J. Mol. Cell. Biol. (1998) [Pubmed]
  6. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Svaren, J., Sevetson, B.R., Apel, E.D., Zimonjic, D.B., Popescu, N.C., Milbrandt, J. Mol. Cell. Biol. (1996) [Pubmed]
  7. Therapeutic applications of the transcriptional corepressor proteins NAB1 and NAB2 in regenerative medicine. Braddock, M., Campbell, C.J., Houston, P. IDrugs : the investigational drugs journal. (2000) [Pubmed]
  8. The human transcriptional repressor protein NAB1: expression and biological activity. Thiel, G., Kaufmann, K., Magin, A., Lietz, M., Bach, K., Cramer, M. Biochim. Biophys. Acta (2000) [Pubmed]
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