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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Fgf20  -  fibroblast growth factor 20

Rattus norvegicus

Synonyms: FGF-20, Fibroblast growth factor 20
 
 
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Disease relevance of Fgf20

  • To examine the biological activity of FGF-20, recombinant rat FGF-20 was produced by insect cells infected with recombinant baculovirus containing rat FGF-20 cDNA [1].
  • No toxicity was noted during administration of FGF-20 to normal controls [2].
  • CONCLUSIONS: FGF-20, having demonstrated therapeutic activity in 2 experimental models of intestinal inflammation, represents a promising new candidate for the treatment of human inflammatory bowel disease [2].
  • In the indomethacin-small bowel ulceration/inflammation model, administration of FGF-20 reduced small intestinal weight gain, necrosis, inflammation, and weight loss (36%-53% relative to vehicle control) [2].
  • RESULTS: In the DSS-colitis model, prophylactic administration of FGF-20 significantly reduced the severity and extent of mucosal damage as indicated by a 55%-93% reduction in luminal blood loss, distal colonic edema, histologic inflammation, and epithelial cell loss relative to animals administered vehicle control [2].
 

High impact information on Fgf20

  • We hereby provide evidence that FGF-20, a growth factor of the FGF family, is expressed in the adult and 6-OHDA-lesioned striatum and substantia nigra, but is not expressed by VM glia or DA neurons, suggesting that FGF-20 may work on DA neurons in a paracrine- or target-derived manner [3].
  • RT-PCR showed, that both, Schwann cells and Nurr1-NSCs (differentiated or not), expressed the FGF-1 receptor suggesting that both direct and indirect actions of FGF-20 are possible [3].
  • FGF-20 slightly enhanced the survival of total neurons of the midbrain, indicating that it preferentially enhanced the survival of dopaminergic neurons [4].
  • Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c [4].
 

Anatomical context of Fgf20

  • Recombinant rat FGF-20 enhanced the survival of midbrain dopaminergic neurons [1].
 

Analytical, diagnostic and therapeutic context of Fgf20

References

  1. FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain. Ohmachi, S., Watanabe, Y., Mikami, T., Kusu, N., Ibi, T., Akaike, A., Itoh, N. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. A novel human fibroblast growth factor treats experimental intestinal inflammation. Jeffers, M., McDonald, W.F., Chillakuru, R.A., Yang, M., Nakase, H., Deegler, L.L., Sylander, E.D., Rittman, B., Bendele, A., Sartor, R.B., Lichenstein, H.S. Gastroenterology (2002) [Pubmed]
  3. Fibroblast growth factor-20 promotes the differentiation of Nurr1-overexpressing neural stem cells into tyrosine hydroxylase-positive neurons. Grothe, C., Timmer, M., Scholz, T., Winkler, C., Nikkhah, G., Claus, P., Itoh, N., Arenas, E. Neurobiol. Dis. (2004) [Pubmed]
  4. Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c. Ohmachi, S., Mikami, T., Konishi, M., Miyake, A., Itoh, N. J. Neurosci. Res. (2003) [Pubmed]
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