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Gene Review

Gdf10  -  growth differentiation factor 10

Mus musculus

Synonyms: BMP-3B, Bmp3b, Bone morphogenetic protein 3B, GDF-10, Growth/differentiation factor 10
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High impact information on Gdf10


Biological context of Gdf10


Anatomical context of Gdf10

  • In addition, GDF-10 mRNA was present in both neonatal and adult bone samples, with higher levels being detected in calvaria than in long bone [3].
  • By Northern analysis, GDF-10 mRNA was detected primarily in murine uterus, adipose tissue, and brain and to a lesser extent in liver and spleen [3].

Analytical, diagnostic and therapeutic context of Gdf10

  • In order to determine the biological function of GDF-10, we carried out a detailed analysis of the expression pattern of GDF-10 and characterized GDF-10-null mice that we generated by gene targeting [1].


  1. Characterization of GDF-10 expression patterns and null mice. Zhao, R., Lawler, A.M., Lee, S.J. Dev. Biol. (1999) [Pubmed]
  2. Localized expression of BMP and GDF mRNA in the rodent brain. Söderström, S., Ebendal, T. J. Neurosci. Res. (1999) [Pubmed]
  3. Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3. Cunningham, N.S., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Reddi, A.H., Lee, S.J. Growth Factors (1995) [Pubmed]
  4. Comparative integromics on BMP/GDF family. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
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