Disease relevance of Post-Traumatic Headache

• Ipsilateral blockades of the C2 root and/or greater occipital nerve allow a differentiation between cervicogenic headache and primary headache syndromes such as migraine or tension-type headache [1].
• Indomethacin exerts an absolute, persistent and clearly dose-dependent effect on this headache, which differs from unilateral headache syndromes such as cluster headache and cervicogenic headache in its temporal pattern and indomethacin response [2].

High impact information on Post-Traumatic Headache

• The results may further support the theory that fibres from the C2 level (innervating the occipital part of the head) may be included in the pathogenetic mechanism in cervicogenic headache [3].
• In a series of 14 patients with cervicogenic headache, cervical nerve blockades (C2-C5 and facet joint C2/C3) have been carried out in order to elucidate possible underlying mechanisms and to evaluate the diagnostic potential of these procedures [4].
• Glycerol gangliotomy of the second dorsal cervical root in rats: an experimental study to evaluate a minimal invasive approach for the treatment of the chronic cervicogenic headache [5].
• A computer-based technique to assess the mobility of the cervical spine demonstrated a statistically pronounced hypomobility of the craniocervical joints C0/C2 and an impaired overall mobility of the upper cervical spine (C0-C5) in the cervicogenic headache group [6].
• Consistent asymmetries of ES2 latency and duration were not found among patients with (unilateral) cervicogenic headache [7].

Chemical compound and disease context of Post-Traumatic Headache

• Cervicogenic headache: responses to nitroglycerin, oxygen, ergotamine and morphine [8].
• Cervicogenic headache: prevalence and response to local steroid therapy [9].
• Nitric oxide (NO) synthase is also activated in cervicogenic headache [10].
• Cervicogenic headache. Long-term results of radiofrequency treatment of the planum nuchale [11].
• This report presents a series of 9 patients suffering from cervicogenic headache and the results achieved by means of epidural steroid (methylprednisolone 40 mg) injection into the epidural cervical space (C6-C7 or C7-T1) level [12].

Analytical, diagnostic and therapeutic context of Post-Traumatic Headache

• In our study we compared the GON and C2/C3 nerve blocks in the diagnosis and treatment of cervicogenic headache [13].

References