The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nerve Block

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Nerve Block


High impact information on Nerve Block

  • A controlled, double-blind investigation was conducted to determine whether the dorsal penile nerve block using lidocaine hydrochloride without epinephrine would effectively reduce behavioral distress and adrenocortical responses to routine neonatal circumcision [6].
  • How do presynaptic PLA2 neurotoxins block nerve terminals [7]?
  • Two fingers on one hand were anesthetized by local injection of lidocaine, and the effectiveness of nerve blocks was verified by plethysmography [8].
  • A decrease in GABA-related cortical inhibition was achieved by ischaemic nerve block (INB) in the hand by deafferentation/deefferentation and an increase was achieved by administration of the GABA(A) receptor agonist lorazepam [9].
  • In PC12 cells, others have shown that 6-TG blocks nerve growth factor-induced neurite outgrowth and selectively inhibits the activity of protein kinase N, a partially characterized, nerve growth factor-inducible serine-threonine kinase [10].

Chemical compound and disease context of Nerve Block


Biological context of Nerve Block


Anatomical context of Nerve Block


Associations of Nerve Block with chemical compounds

  • In summary, coencapsulation of TTX in controlled release devices containing bupivacaine and dexamethasone resulted in very prolonged nerve blocks [26].
  • The assay we describe was developed to monitor plasma concentrations of phenol in children given motor point nerve blocks with dilute phenol [27].
  • Ropivacaine (Naropin) is the pure S(-)-enantiomer of propivacaine, and is a long-acting amide local anaesthetic agent, eliciting nerve block via reversible inhibition of sodium ion influx in nerve fibres.Ropivacaine is a well tolerated regional anaesthetic effective for surgical anaesthesia as well as the relief of postoperative and labour pain [28].
  • The analgesic effects of infraorbital nerve block using 0.5% bupivacaine or 1% mepivacaine dissipated within a few days, however, the effects of nerve blocks using 4% tetracaine dissolved in 0.5% bupivacaine continued for more than 3 months [29].
  • The data available suggest that, where prophylactic use of heparin is concerned, and provided the administration of the last dose of heparin and the institution of a regional anaesthetic nerve block does not occur at the same time, use of regional anaesthesia is not contraindicated in such circumstances [30].

Gene context of Nerve Block

  • In previous work it was shown that parats (paralyzed, temperature-sensitive, 1-53.9) and napts (no action potential, temperature-sensitive, 2-56.2), two temperature-sensitive paralytic mutations that block nerve conduction at restrictive temperatures, interact synergistically in double mutants causing unconditional lethality [31].
  • Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells [32].
  • The aim of performing celiac plexus and splancnic nerve blocks was surgical anesthesia at the beginning [33].
  • Ropivacaine is a long-acting, enantiomerically pure (S-enantiomer) amide local anaesthetic with a high pKa and low lipid solubility which blocks nerve fibres involved in pain transmission (Adelta and C fibres) to a greater degree than those controlling motor function (Abeta fibres) [34].
  • Paired comparisons of rCBF were made between the patient's habitual pain (HP) state and the pain alleviated (PA) state following a successful regional nerve block (RNB) with lidocaine [35].

Analytical, diagnostic and therapeutic context of Nerve Block


  1. Lumbar radiculopathy: treatment with selective lumbar nerve blocks--comparison of effectiveness of triamcinolone and betamethasone injectable suspensions. Blankenbaker, D.G., De Smet, A.A., Stanczak, J.D., Fine, J.P. Radiology. (2005) [Pubmed]
  2. Digital vasodilatation during mental stress in patients with Raynaud's disease. Halperin, J.L., Cohen, R.A., Coffman, J.D. Cardiovasc. Res. (1983) [Pubmed]
  3. Suprascapular nerve block (using bupivacaine and methylprednisolone acetate) in chronic shoulder pain. Shanahan, E.M., Ahern, M., Smith, M., Wetherall, M., Bresnihan, B., FitzGerald, O. Ann. Rheum. Dis. (2003) [Pubmed]
  4. Delta-protein kinase C phosphorylation parallels inhibition of nerve growth factor-induced differentiation independent of changes in Trk A and MAP kinase signalling in PC12 cells. Wooten, M.W., Seibenhener, M.L., Heikkila, J.E., Mischak, H. Cell. Signal. (1998) [Pubmed]
  5. Double blind randomized clinical trial examining the efficacy of bupivacaine suprascapular nerve blocks in frozen shoulder. Dahan, T.H., Fortin, L., Pelletier, M., Petit, M., Vadeboncoeur, R., Suissa, S. J. Rheumatol. (2000) [Pubmed]
  6. Local anesthesia for neonatal circumcision. Effects on distress and cortisol response. Stang, H.J., Gunnar, M.R., Snellman, L., Condon, L.M., Kestenbaum, R. JAMA (1988) [Pubmed]
  7. How do presynaptic PLA2 neurotoxins block nerve terminals? Montecucco, C., Rossetto, O. Trends Biochem. Sci. (2000) [Pubmed]
  8. Induction of vasospastic attacks despite digital nerve block in Raynaud's disease and phenomenon. Freedman, R.R., Mayes, M.D., Sabharwal, S.C. Circulation (1989) [Pubmed]
  9. Modulation of practice-dependent plasticity in human motor cortex. Ziemann, U., Muellbacher, W., Hallett, M., Cohen, L.G. Brain (2001) [Pubmed]
  10. Axon outgrowth is regulated by an intracellular purine-sensitive mechanism in retinal ganglion cells. Benowitz, L.I., Jing, Y., Tabibiazar, R., Jo, S.A., Petrausch, B., Stuermer, C.A., Rosenberg, P.A., Irwin, N. J. Biol. Chem. (1998) [Pubmed]
  11. Hyperalgesia caused by nerve transection: long-lasting block prevents early hyperalgesia in the receptive field of the surviving nerve. Kissin, I., Lee, S.S., Bradley, E.L. Anesth. Analg. (1999) [Pubmed]
  12. Treatment of intercostal neuralgia with 10 per cent ammonium sulfate. Miller, R.D., Johnston, R.R., Hosobuchi, Y. J. Thorac. Cardiovasc. Surg. (1975) [Pubmed]
  13. The effect of pudendal block on voiding after hemorrhoidectomy. Kim, J., Lee, D.S., Jang, S.M., Shim, M.C., Jee, D.L. Dis. Colon Rectum (2005) [Pubmed]
  14. Intralesional steroid injection after nerve block anesthesia in the treatment of orofacial granulomatosis. Sakuntabhai, A., MacLeod, R.I., Lawrence, C.M. Archives of dermatology. (1993) [Pubmed]
  15. Repeated nerve blocks with clonidine, fentanyl and bupivacaine for trigeminal neuralgia. Naja, M.Z., Al-Tannir, M., Naja, H., Ziade, M.F., Zeidan, A. Anaesthesia. (2006) [Pubmed]
  16. A monoclonal antibody to Borrelia burgdorferi flagellin modifies neuroblastoma cell neuritogenesis in vitro: a possible role for autoimmunity in the neuropathy of Lyme disease. Sigal, L.H., Williams, S. Infect. Immun. (1997) [Pubmed]
  17. Meperidine and lidocaine block of recombinant voltage-dependent Na+ channels: evidence that meperidine is a local anesthetic. Wagner, L.E., Eaton, M., Sabnis, S.S., Gingrich, K.J. Anesthesiology (1999) [Pubmed]
  18. Effect of epinephrine on lidocaine clearance in vivo: a microdialysis study in humans. Bernards, C.M., Kopacz, D.J. Anesthesiology (1999) [Pubmed]
  19. Physiologic stress reduction by a local anesthetic during newborn circumcision. Williamson, P.S., Williamson, M.L. Pediatrics (1983) [Pubmed]
  20. Nociceptive quality of the laser-evoked blink reflex in humans. Romaniello, A., Valls-Solé, J., Iannetti, G.D., Truini, A., Manfredi, M., Cruccu, G. J. Neurophysiol. (2002) [Pubmed]
  21. Sprouting of active nerve terminals in partially inactive muscles of the rat. Betz, W.J., Caldwell, J.H., Ribchester, R.R. J. Physiol. (Lond.) (1980) [Pubmed]
  22. Detrusor bladder neck dyssynergia revisited. Schurch, B., Yasuda, K., Rossier, A.B. J. Urol. (1994) [Pubmed]
  23. Percutaneous-guided pain control: exploiting the neural basis of pain sensation. Adolph, M.D., Benedetti, C. Gastroenterol. Clin. North Am. (2006) [Pubmed]
  24. Mitogen activated protein kinase inhibition by PD98059 blocks nerve growth factor stimulated axonal outgrowth from adult mouse dorsal root ganglia in vitro. Sjögreen, B., Wiklund, P., Ekström, P.A. Neuroscience (2000) [Pubmed]
  25. Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block. Kinirons, B.P., Bouaziz, H., Paqueron, X., Ababou, A., Jandard, C., Cao, M.M., Bur, M.L., Laxenaire, M.C., Benhamou, D. Anesth. Analg. (2000) [Pubmed]
  26. Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Kohane, D.S., Smith, S.E., Louis, D.N., Colombo, G., Ghoroghchian, P., Hunfeld, N.G., Berde, C.B., Langer, R. Pain (2003) [Pubmed]
  27. Microtechnique for quantifying phenol in plasma by gas chromatography-mass spectrometry. Harrison, L.M., Morrison, J.E., Fennessey, P.V. Clin. Chem. (1991) [Pubmed]
  28. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Simpson, D., Curran, M.P., Oldfield, V., Keating, G.M. Drugs (2005) [Pubmed]
  29. The long lasting effects of peripheral nerve blocks for trigeminal neuralgia using high concentration of tetracaine dissolved in bupivacaine. Goto, F., Ishizaki, K., Yoshikawa, D., Obata, H., Arii, H., Terada, M. Pain (1999) [Pubmed]
  30. Perioperative management of drug therapy, clinical considerations. Smith, M.S., Muir, H., Hall, R. Drugs (1996) [Pubmed]
  31. Neurogenetic analysis of Drosophila mutations affecting sodium channels: synergistic effects on viability and nerve conduction in double mutants involving tip-E. Ganetzky, B. J. Neurogenet. (1986) [Pubmed]
  32. Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells. Kalman, D., Whittaker, K., Bishop, J.M., O'Lague, P.H. Mol. Biol. Cell (1993) [Pubmed]
  33. Celiac ganglion block. Erdine, S. Aǧrı : Ağrı (Algoloji) Derneği'nin Yayın organıdır = The journal of the Turkish Society of Algology. (2005) [Pubmed]
  34. Ropivacaine: an update of its use in regional anaesthesia. McClellan, K.J., Faulds, D. Drugs (2000) [Pubmed]
  35. Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Hsieh, J.C., Belfrage, M., Stone-Elander, S., Hansson, P., Ingvar, M. Pain (1995) [Pubmed]
  36. A comparison between bupivacaine instillation versus ilioinguinal/iliohypogastric nerve block for postoperative analgesia following inguinal herniorrhaphy in children. Casey, W.F., Rice, L.J., Hannallah, R.S., Broadman, L., Norden, J.M., Guzzetta, P. Anesthesiology (1990) [Pubmed]
  37. Quantitative assessment of differential sensory nerve block after lidocaine spinal anesthesia. Liu, S., Kopacz, D.J., Carpenter, R.L. Anesthesiology (1995) [Pubmed]
  38. Suprascapular nerve block prolongs analgesia after nonarthroscopic shoulder surgery but does not improve outcome. Neal, J.M., McDonald, S.B., Larkin, K.L., Polissar, N.L. Anesth. Analg. (2003) [Pubmed]
  39. Lumbar segmental nerve blocks with local anesthetics, pain relief, and motor function: a prospective double-blind study between lidocaine and ropivacaine. Wolff, A.P., Wilder Smith, O.H., Crul, B.J., van de Heijden, M.P., Groen, G.J. Anesth. Analg. (2004) [Pubmed]
  40. Evaluation of bupivacaine nerve blocks in the modification of pain and pulmonary function changes after thoracotomy. Woltering, E.A., Flye, M.W., Huntley, S., Kapp, P., Dwyer, A., McLees, B. Ann. Thorac. Surg. (1980) [Pubmed]
WikiGenes - Universities