Disease relevance of Candidiasis, Vulvovaginal

• Complete absence of the entrance signs and symptoms of vulvovaginal candidiasis was noted in 82% of patients receiving butoconazole and 72% of patients receiving clotrimazole [1].
• Pattern of Candida species isolated from patients with diabetes mellitus and vulvovaginal candidiasis and their response to single dose oral fluconazole therapy [2].
• Fluconazole (Diflucan((R)), Pfizer) is a triazole that has established an exceptional therapeutic record for candida infections including oropharyngeal and esophageal candidiasis, vulvovaginal candidiasis, candidemia and disseminated candidiasis [3].

High impact information on Candidiasis, Vulvovaginal

• It appears that maintenance prophylactic therapy with oral ketoconazole is effective in preventing recurrent episodes of vulvovaginal candidiasis, but that relapse is common after withdrawal of the drug [4].
• Two therapeutic regimens were used to treat vulvovaginal candidiasis with clotrimazole vaginal tablets [5].
• Immunoglobulin G (IgG) and T-cell-derived antigen binding molecules (TABM) specific to whole Candida extract and to Candida-derived mannans prepared by both the cetryltrimethylammonium bromide (CTAB) and alkaline degradation (PEAT) methods were measured in the sera of women with vulvovaginal candidiasis and controls [6].
• Evidence for a role for secreted aspartate proteinase of Candida albicans in vulvovaginal candidiasis [7].
• Single-dose tioconazole compared with 3-day clotrimazole treatment in vulvovaginal candidiasis [8].

Chemical compound and disease context of Candidiasis, Vulvovaginal

• CONCLUSION: We recommend that a single oral dose of 150 mg of fluconazole be given as an alternative method of treating vulvovaginal candidiasis, but the cost is higher than for clotrimazole [9].
• Topical antifungal agents of the imidazole class are superior to polyenes in treating vulvovaginal candidiasis [10].
• A randomized multiregimen clinical study was undertaken using Monistat Cream for the treatment of vulvovaginal candidiasis [11].
• Three-day treatment with butoconazole nitrate for vulvovaginal candidiasis [1].
• Patient acceptance of a new, compact, prefilled disposable vaginal applicator was tested in an open study in which 2% butoconazole cream was used for the treatment of vulvovaginal candidiasis [12].

Anatomical context of Candidiasis, Vulvovaginal

• SUMMARY: Instead of vulvovaginal candidiasis being caused by defective or dysfunctional CD4 T helper 1-type cell-mediated immune reactivity, data suggest that symptomatic vulvovaginal candidiasis is associated with an aggressive response by polymorphonuclear neutrophils, whereas protection appears to be innate and noninflammatory [13].

Gene context of Candidiasis, Vulvovaginal

• Over-the-counter (OTC) antifungal products for vulvovaginal candidiasis (VVC) have gained tremendous popularity, as evidenced by staggering increases in sales since the products were switched from prescription-only to OTC status [14].
• BACKGROUND: Recurrent vulvovaginal candidiasis (VVC) has been linked to allergic disease, particularly allergic rhinitis [15].
• OBJECTIVE: We differentiated women with vulvar vestibulitis syndrome into subgroups on the basis of the time of symptom onset, a history of recurrent vulvovaginal candidiasis, and the interleukin-1 receptor antagonist gene polymorphism [16].
• In this study the prevalence of vulvovaginal candidiasis (VVC), antifungal susceptibility and proteinase production of isolated Candida species were investigated [17].
• However, the risk of developing vulvovaginal candidiasis was increased 6.8 times for women with CD4 counts less than 200 cells/mm3 at baseline [18].

Analytical, diagnostic and therapeutic context of Candidiasis, Vulvovaginal

• Clotrimazole 1 per cent vaginal cream administered daily over a seven-day period was compared with miconazole nitrate 2 per cent vaginal cream administered daily over a 14 day period for the treatment of vulvovaginal candidiasis in a double-blind study of 65 women with clinical symptoms of this condition,, for whom treatment was randomly allocated [19].

References