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Chemical Compound Review

temephos     [4-(4- dimethoxyphosphinothioyloxyphe nyl)su...

Synonyms: Abathion, Biothion, Abaphos, Bithion, Difenphos, ...
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Disease relevance of Temefos

  • In the present study, four populations of the same field mosquito species, Ochlerotatus cataphylla, were sampled over the Rh6ne-Alpes region (France), and their respective sensitivity to the organophosphate temephos and the bacterio-insecticide Bacillus thuringiensis var. israelensis (Bti) was measured [1].
  • Temephos (Abate) metabolism and toxicity in rats [2].
  • Use of temephos larvicide in solid form for the control of onchocerciasis in Guatemala [3].
  • Resistance of the dengue vector to temephos stimulated its substitution for Bacillus thuringiensis var. israelensis (Bti) since 2001 in Brazil [4].
  • A study to evaluate the impact of different dose/frequency of temephos 50% ec for control of Cx. quinquefasciatus vector of bancroftian filariasis [5].

High impact information on Temefos

  • The present study identifies an alpha 1AT allele (referred to as "Null(isola di procida")) caused by complete deletion of the alpha 1AT coding exons [6].
  • Larvicidal efficacy against Aedes aegypti mosquitoes of zedoary oil and its formulated preparation, zedoary oil-impregnated sand granules, were investigated and compared with that of Abate(R)sand (temephos) [7].
  • In July 1997, telemedicine services were established for two islands, Procida and Ischia, in the Bay of Naples [8].
  • Efficacy of polyvinyl chloride collars containing temephos [0,0'-(thiodi-4,1-phenylene) 0,0,0',0'-tetramethyl bis-(phosphorothioate)] was elevaluated in dogs and cats against the cat flea (Ctenocephalides felis) [9].
  • The selected larvicides included, two organophosphate (OP) compounds (temephos and pirimiphos-methyl), two microbial larvicides (Bacillus thuringiensis spp. israelensis [Bti] de Barjac and Bacillus sphaericus [Bs] Neide), and an insect growth regulator (IGR) (s-methoprene) [10].

Chemical compound and disease context of Temefos

  • Larvicides remain as an important salt-marsh integrated pest management tool with the greatest acreage being treated with temephos, followed by Bacillus thuringiensis israelensis and methoprene [11].
  • Additionally, the treated population has demonstrated resistance to temephos (Abate), the larvicide currently utilized in the Onchocerciasis Control Programme. Other species of Simulium were somewhat less affected by the treatment; living larvae were found 4 km downstream of the treatment point [12].

Biological context of Temefos

  • Cloning and mapping of the Null(isola di procida) gene demonstrated a deletion of a 17-kb fragment that included exons II-V of the alpha 1AT structural gene [6].
  • The impact of mosquito control on nontarget organisms using Abate-4-E was investigated in terms of immediate mortality and residual activity [13].
  • In this same year the Brazilian Health Foundation started the coordination of the Ae. aegypti Insecticide Resistance Monitoring Program. In the context of this program, our group was responsible for the detection of temephos resistance in a total of 12 municipalities in the states of Rio de Janeiro (RJ), Alagoas (AL), and Sergipe (SE) during 2001 [14].
  • However, temephos at concentrations above 3.33 micro M was mutagenic to TA98NR, YG7104 and YG7108, both with and without metabolic activation [15].
  • Effects of an organophosphorus insecticide (Temephos) on gametogenesis in the leech Hirudinaria manillensis (Hirudinidae) [16].

Associations of Temefos with other chemical compounds

  • The susceptibility of Aedes aegypti (L.) larvae from several Brazilian populations to the juvenile hormone analog methoprene and the organophosphate insecticide temephos were investigated [17].
  • Both alleles provide low but significant resistance to chlorpyrifos (relative synergism ratio [RSR] > 3) and temephos (RSR = 1.4), which is consistent with the low level of gene amplification they display (15 copies for Ester9 and 4 copies for Ester8) [18].
  • Intensive use of the organophosphate insecticide malathion against adults and temephos against larvae of Aedes aegypti in Mexico over the past 30 years has led to problems requiring the use of new larvicides [19].
  • This study was conducted to investigate the preliminary environmental and mammalian toxicology of neem oil, temephos and chlorpyriphos-methyl/fenitrothion [20].
  • The larvicidal activity of chlorpyrifos-methyl and temephos was evaluated against Culex pipiens L [21].

Gene context of Temefos

  • The esterase inhibitor (S,S,S-tributyl phosphorotrithioate, DEF) or synergist implicated detoxifying esterase in all the temephos selected groups and the presence of elevated esterase were confirmed by biochemical assay [22].
  • While R. culicivorax did not adapt to the leaf axil habitat, all plants were without larvae for 5 weeks after treatment with temephos [23].
  • Adult A. sundaicus were found highly susceptible to DDT and larvae to Temephos (Abate) [24].

Analytical, diagnostic and therapeutic context of Temefos


  1. Differential sensitivity to Bacillus thuringiensis var. israelensis and temephos in field mosquito populations of Ochlerotatus cataphylla (Diptera: Culicidae): toward resistance? Boyer, S., Tilquin, M., Ravanel, P. Environ. Toxicol. Chem. (2007) [Pubmed]
  2. Temephos (Abate) metabolism and toxicity in rats. Ferguson, P.W., Medon, P.J., Nasri, E. Arch. Environ. Contam. Toxicol. (1985) [Pubmed]
  3. Use of temephos larvicide in solid form for the control of onchocerciasis in Guatemala. Matsuo, K. Bulletin of the Pan American Health Organization. (1984) [Pubmed]
  4. Residual effect of two Bacillus thuringiensis var. israelensis products assayed against Aedes aegypti (Diptera: Culicidae) in laboratory and outdoors at Rio de Janeiro, Brazil. Lima, J.B., de Melo, N.V., Valle, D. Rev. Inst. Med. Trop. Sao Paulo (2005) [Pubmed]
  5. A study to evaluate the impact of different dose/frequency of temephos 50% ec for control of Cx. quinquefasciatus vector of bancroftian filariasis. Patnaik, S.K., Kanhekar, L.J., Rao, P.K., Raina, V.K., Kumar, A. The Journal of communicable diseases. (1997) [Pubmed]
  6. Alpha 1-antitrypsin Null(isola di procida): an alpha 1-antitrypsin deficiency allele caused by deletion of all alpha 1-antitrypsin coding exons. Takahashi, H., Crystal, R.G. Am. J. Hum. Genet. (1990) [Pubmed]
  7. Larvicidal efficacy and biological stability of a botanical natural product, zedoary oil-impregnated sand granules, against Aedes aegypti (Diptera, Culicidae). Champakaew, D., Choochote, W., Pongpaibul, Y., Chaithong, U., Jitpakdi, A., Tuetun, B., Pitasawat, B. Parasitol. Res. (2007) [Pubmed]
  8. Telemedicine services for two islands in the Bay of Naples. Bracale, M., Cesarelli, M., Bifulco, P. Journal of telemedicine and telecare. (2002) [Pubmed]
  9. Temephos collars for control of fleas on dogs and cats. Baker, N.F., Miller, J.E. Am. J. Vet. Res. (1977) [Pubmed]
  10. Sublethal effects of mosquito larvicides on swimming performance of larvivorous fish Melanotaenia duboulayi (Atheriniformes: Melanotaeniidae). Hurst, T.P., Kay, B.H., Ryan, P.A., Brown, M.D. J. Econ. Entomol. (2007) [Pubmed]
  11. Florida's salt-marsh management issues: 1991-98. Carlson, D.B., O'Bryan, P.D., Rey, J.R. J. Am. Mosq. Control Assoc. (1999) [Pubmed]
  12. Large river treatment with Bacillus thuringiensis (H-14) for the control of Simulium damnosum s.l. in the Onchocerciasis Control Programme. Lacey, L.A., Escaffre, H., Philippon, B., Sékétéli, A., Guillet, P. Tropenmedizin und Parasitologie. (1982) [Pubmed]
  13. The residual effect of temephos (Abate 4-E) on nontarget communities. Fortin, C., Maire, A., Leclair, R. J. Am. Mosq. Control Assoc. (1987) [Pubmed]
  14. Aedes aegypti resistance to temephos during 2001 in several municipalities in the states of Rio de Janeiro, Sergipe, and Alagoas, Brazil. Braga, I.A., Lima, J.B., Soares, S.d.a. .S., Valle, D. Mem. Inst. Oswaldo Cruz (2004) [Pubmed]
  15. Genotoxic evaluation of the organophosphorous pesticide temephos. Aiub, C.A., Coelho, E.C., Sodré, E., Pinto, L.F., Felzenszwalb, I. Genet. Mol. Res. (2002) [Pubmed]
  16. Effects of an organophosphorus insecticide (Temephos) on gametogenesis in the leech Hirudinaria manillensis (Hirudinidae). Singhal, R.N., Davies, R.W. J. Invertebr. Pathol. (1996) [Pubmed]
  17. Effectiveness of methoprene, an insect growth regulator, against temephos-resistant Aedes aegypti populations from different Brazilian localities, under laboratory conditions. Braga, I.A., Mello, C.B., Montella, I.R., Lima, J.B., Martins, A.d.e. .J., Medeiros, P.F., Valle, D. J. Med. Entomol. (2005) [Pubmed]
  18. Identification and characterization of novel organophosphate detoxifying esterase alleles in the Guangzhou area of China. Weill, M., Marquine, M., Berthomieu, A., Dubois, M.P., Bernard, C., Qiao, C.L., Raymond, M. J. Am. Mosq. Control Assoc. (2001) [Pubmed]
  19. Laboratory evaluation of Vectobac as against Aedes aegypti in Monterrey, Nuevo León, Mexico. Ponce G, G., Flores, A.E., Badii, M.H., Rodríguez-Tovar, M.L., Fernández-Salas, I. J. Am. Mosq. Control Assoc. (2002) [Pubmed]
  20. Operational use of neem oil as an alternative anopheline larvicide. Part B: Environmental impact and toxicological potential. Awad, O.M. Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ. (2003) [Pubmed]
  21. Evaluation of temephos and chlorpyrifos-methyl against Culex pipiens (Diptera: Culicidae) larvae in septic tanks in Antalya, Turkey. Cetin, H., Yanikoglu, A., Kocak, O., Cilek, J.E. J. Med. Entomol. (2006) [Pubmed]
  22. Temephos resistance in two forms of Aedes aegypti and its significance for the resistance mechanism. Paeporn, P., Komalamisra, N., Deesin, V., Rongsriyam, Y., Eshita, Y., Thongrungkiat, S. Southeast Asian J. Trop. Med. Public Health (2003) [Pubmed]
  23. Distribution of breeding and control of the filariasis vector Aedes samoanus in leaf axils of Pandanus in Samoa. Samarawickrema, W.A., Sone, F., Self, L.S., Cummings, R.F., Paulson, G.S. Med. Vet. Entomol. (1992) [Pubmed]
  24. Studies on malaria and filariasis vectors in Kamorta and Great Nicobar Islands. Das, S.C., Nath, D.R., Bhuyan, M., Das, N.G., Baruah, I., Talukdar, P.K. Indian journal of malariology. (1989) [Pubmed]
  25. Residual concentration and efficacy of three temephos formulations for control of larval Aedes aegypti. Cilek, J.E., Webb, J.D., Knapp, F.W. J. Am. Mosq. Control Assoc. (1991) [Pubmed]
  26. Transmission of Onchocerca volvulus and prospects for the elimination of its vector, the blackfly Simulium neavei in the Mpamba-Nkusi focus in Western Uganda. Lakwo, T.L., Ndyomugyenyi, R., Onapa, A.W., Twebaze, C. Med. Vet. Entomol. (2006) [Pubmed]
  27. Cross-resistance to pyrethroid and organophosphorus insecticides induced by selection with temephos in Aedes aegypti (Diptera: Culicidae) from Cuba. Rodríguez, M.M., Bisset, J., Ruiz, M., Soca, A. J. Med. Entomol. (2002) [Pubmed]
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