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Chemical Compound Review

deltamethrin     [cyano-(3- phenoxyphenyl)methyl] 3-(2,2...

Synonyms: NRDC 16, AGN-PC-00JVP8, NRDC 156, NRDC 158, AG-K-23851, ...
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Disease relevance of deltamethrin

  • Deltamethrin spray is effective for fly control and may be useful for reducing trachoma and diarrhoea in some situations, but further research on sustainable fly-control methods is needed [1].
  • Phentolamine reduced glucagon release (IC(50) = 1.2 microm) from intact islets by 40%, an effect abolished by pertussis toxin, cyclosporin A, and deltamethrin [2].
  • The combined effects on sand fly feeding and survival indicate that epidemiologic, community-based trials are warranted to test whether deltamethrin collars could reduce the incidence of canine and, hence, human leishmaniasis [3].
  • Stabilization of sodium channel states by deltamethrin in mouse neuroblastoma cells [4].
  • Treated animals did not recover during the time-course of the experiment (365 days after treatment); however, deltamethrin did not affect the body weight of the treated animals during the course of the study [5].

Psychiatry related information on deltamethrin

  • Results from the interaction studies indicate dose-addition of the effects of picrotoxin and deltamethrin on motor activity and the ASR [6].
  • Additionally, route-response (i.p., oral and s.c.), time-response (6, 24 and 48 h) and acute-chronic (24 versus 120 h) studies were conducted for the induction of chromosome aberrations by the highest dose (20 mg/kg) of deltamethrin [7].
  • Avoidance behavior appears to be an innate behavior of mosquitoes, as indicated by the general avoidance response detected in all 4 species, regardless of deltamethrin susceptibility status, age, or nutritional and physiological status [8].

High impact information on deltamethrin


Chemical compound and disease context of deltamethrin


Biological context of deltamethrin


Anatomical context of deltamethrin


Associations of deltamethrin with other chemical compounds


Gene context of deltamethrin


Analytical, diagnostic and therapeutic context of deltamethrin

  • Whole cell recording showed that deltamethrin prolonged sodium currents in neuroblastoma cells by several orders of magnitude [4].
  • Finally, considering reports about the genotoxicity of deltamethrin, we assessed DNA damage in children before and 24 hr after indoor spraying of deltamethrin; we found no differences in the comet assay end points [33].
  • The inferred presence of kdr-type resistance in the four E4 clones was subsequently confirmed by bioassays that showed this to be the primary mechanism of resistance to deltamethrin and DDT, although the esterase-based mechanism also contributes to the overall level of deltamethrin resistance [34].
  • Separation and identification of enantiomers by high-performance liquid chromatography with a chiral column and a polarimetric detector as applied to deltamethrin [35].
  • RT-PCR analysis revealed dose-dependent increase in the mRNA expression of cerebral and hepatic CYP1A1, 1A2, 2B1, 2B2, and 2E1 isoenzymes in the offsprings exposed prenatally to deltamethrin [36].


  1. Effect of fly control on trachoma and diarrhoea. Emerson, P.M., Lindsay, S.W., Walraven, G.E., Faal, H., Bøgh, C., Lowe, K., Bailey, R.L. Lancet (1999) [Pubmed]
  2. Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells. Høy, M., Bokvist, K., Xiao-Gang, W., Hansen, J., Juhl, K., Berggren, P.O., Buschard, K., Gromada, J. J. Biol. Chem. (2001) [Pubmed]
  3. Topical insecticide treatments to protect dogs from sand fly vectors of leishmaniasis. Reithinger, R., Teodoro, U., Davies, C.R. Emerging Infect. Dis. (2001) [Pubmed]
  4. Stabilization of sodium channel states by deltamethrin in mouse neuroblastoma cells. Chinn, K., Narahashi, T. J. Physiol. (Lond.) (1986) [Pubmed]
  5. Deltamethrin-induced thymus atrophy in male Balb/c mice. Enan, E., Pinkerton, K.E., Peake, J., Matsumura, F. Biochem. Pharmacol. (1996) [Pubmed]
  6. Pyrethroid insecticides and the gamma-aminobutyric acidA receptor complex: motor activity and the acoustic startle response in the rat. Crofton, K.M., Reiter, L.W. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  7. Effect of deltamethrin, a synthetic pyrethroid, on the induction of chromosome aberrations, micronuclei and sperm abnormalities in mice. Bhunya, S.P., Pati, P.C. Mutagenesis (1990) [Pubmed]
  8. Excito-repellency of deltamethrin on the malaria vectors, Anopheles minimus, Anopheles dirus, Anopheles swadiwongporni, and Anopheles maculatus, in Thailand. Chareonviriyaphap, T., Prabaripai, A., Bangs, M.J. J. Am. Mosq. Control Assoc. (2004) [Pubmed]
  9. Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4. Ranta, F., Avram, D., Berchtold, S., Düfer, M., Drews, G., Lang, F., Ullrich, S. Diabetes (2006) [Pubmed]
  10. Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells. Macdonald, P.E., Eliasson, L., Rorsman, P. J. Cell. Sci. (2005) [Pubmed]
  11. A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyrethroid action. Wang, S.Y., Barile, M., Wang, G.K. Mol. Pharmacol. (2001) [Pubmed]
  12. Characterization of deltamethrin metabolism by rat plasma and liver microsomes. Anand, S.S., Bruckner, J.V., Haines, W.T., Muralidhara, S., Fisher, J.W., Padilla, S. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  13. Pyrethroid insecticides and sediment toxicity in urban creeks from California and Tennessee. Amweg, E.L., Weston, D.P., You, J., Lydy, M.J. Environ. Sci. Technol. (2006) [Pubmed]
  14. Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat. Crofton, K.M., Reiter, L.W. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
  15. Effects of prenatal exposure to deltamethrin on forced swimming behavior, motor activity, and striatal dopamine levels in male and female rats. Lazarini, C.A., Florio, J.C., Lemonica, I.P., Bernardi, M.M. Neurotoxicology and teratology. (2001) [Pubmed]
  16. Joint actions of deltamethrin and azole fungicides on honey bee thermoregulation. Vandame, R., Belzunces, L.P. Neurosci. Lett. (1998) [Pubmed]
  17. Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations. Vais, H., Williamson, M.S., Goodson, S.J., Devonshire, A.L., Warmke, J.W., Usherwood, P.N., Cohen, C.J. J. Gen. Physiol. (2000) [Pubmed]
  18. Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. Gromada, J., Høy, M., Buschard, K., Salehi, A., Rorsman, P. J. Physiol. (Lond.) (2001) [Pubmed]
  19. Potent modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels by the type II pyrethroid deltamethrin. Tabarean, I.V., Narahashi, T. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  20. Activation of phosphoinositide/protein kinase C pathway in rat brain tissue by pyrethroids. Enan, E., Matsumura, F. Biochem. Pharmacol. (1993) [Pubmed]
  21. Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells. Düfer, M., Krippeit-Drews, P., Lembert, N., Idahl, L.A., Drews, G. Mol. Pharmacol. (2001) [Pubmed]
  22. Regulation of ATP-induced calcium release in COS-7 cells by calcineurin. Bandyopadhyay, A., Shin, D.W., Kim, D.H. Biochem. J. (2000) [Pubmed]
  23. Deltamethrin, a pyrethroid insecticide, is a potent inducer for the activity-dependent gene expression of brain-derived neurotrophic factor in neurons. Imamura, L., Yasuda, M., Kuramitsu, K., Hara, D., Tabuchi, A., Tsuda, M. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  24. Role of ion channels and intraterminal calcium homeostasis in the action of deltamethrin at presynaptic nerve terminals. Clark, J.M., Brooks, M.W. Biochem. Pharmacol. (1989) [Pubmed]
  25. Sensitivity of the Drosophila para sodium channel to DDT is not lowered by the super-kdr mutation M918T on the IIS4-S5 linker that profoundly reduces sensitivity to permethrin and deltamethrin. Usherwood, P.N., Vais, H., Khambay, B.P., Davies, T.G., Williamson, M.S. FEBS Lett. (2005) [Pubmed]
  26. Involvement of peripheral-type benzodiazepine receptors in the proconvulsant actions of pyrethroid insecticides. Devaud, L.L., Murray, T.F. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  27. A novel action of deltamethrin on membrane resistance in mammalian skeletal muscle and non-myelinated nerve fibres. Forshaw, P.J., Ray, D.E. Neuropharmacology (1990) [Pubmed]
  28. Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides. Enan, E., Matsumura, F. Biochem. Pharmacol. (1992) [Pubmed]
  29. Regional specificity in deltamethrin induced cytochrome P450 expression in rat brain. Yadav, S., Johri, A., Dhawan, A., Seth, P.K., Parmar, D. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  30. Changes in enzyme titres with age in four geographical strains of Aedes aegypti and their association with insecticide resistance. Mourya, D.T., Hemingway, J., Leake, C.J. Med. Vet. Entomol. (1993) [Pubmed]
  31. Effects of deltamethrin on lipid peroxidation in mice. Yarsan, E., Bilgili, A., Kanbur, M., Celik, S. Veterinary and human toxicology. (2002) [Pubmed]
  32. Deltamethrin induces apoptotic cell death in cultured cerebral cortical neurons. Wu, A., Li, L., Liu, Y. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  33. Environmental health assessment of deltamethrin in a malarious area of Mexico: environmental persistence, toxicokinetics, and genotoxicity in exposed children. Ortiz-Pérez, M.D., Torres-Dosal, A., Batres, L.E., López-Guzmán, O.D., Grimaldo, M., Carranza, C., Pérez-Maldonado, I.N., Martínez, F., Pérez-Urizar, J., Díaz-Barriga, F. Environ. Health Perspect. (2005) [Pubmed]
  34. A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in the peach-potato aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae). Martinez-Torres, D., Foster, S.P., Field, L.M., Devonshire, A.L., Williamson, M.S. Insect Mol. Biol. (1999) [Pubmed]
  35. Separation and identification of enantiomers by high-performance liquid chromatography with a chiral column and a polarimetric detector as applied to deltamethrin. Meinard, C., Bruneau, P. J. Chromatogr. (1988) [Pubmed]
  36. Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cytochrome P450s in the brain and liver of offsprings. Johri, A., Dhawan, A., Lakhan Singh, R., Parmar, D. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
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