Disease relevance of Cartilage Diseases

• To use a recently developed procedure for analysis of blood leukocyte DNA to detect mutations in the gene for type II procollagen (COL2A1) in patients with cartilage diseases ranging from early-onset familial osteoarthritis (OA) to lethal chondrodysplasias [1].
• Serum MGP concentrations were significantly decreased in patients with angina pectoris and in various cartilage diseases [2].

High impact information on Cartilage Diseases

• Hence, the EP2 agonist may be a potent therapeutic agent for degenerative cartilage diseases [3].
• The goal is to stimulate critical thought and discussion in the field about cartilage fibronectin isoforms, their function(s) in normal cartilage, and their role(s) in the pathogenesis of cartilage diseases [4].
• A more complete understanding of the role of TGF-beta and its down-stream signals will lead to improved understanding and treatment of cartilage diseases [5].
• DDP is a potential indicator of cartilage metabolism during normal growth, ageing, and cartilage disease [6].
• Our findings point to a pathological role for serine proteinase(s) in the development of cartilage diseases such as arthritis, possibly in a cascade which results in the activation of the enzyme(s) directly responsible for proteoglycan breakdown [7].

Chemical compound and disease context of Cartilage Diseases

• This bone/cartilage disease failed to respond to phosphate supplementation, parathyroidectomy and calcitriol [8].

Biological context of Cartilage Diseases

• The technique of denaturing gradient gel electrophoresis was used to scan polymerase chain reaction (PCR) products from 45 exons and exon-flanking sequences of the COL2A1 gene in more than 70 patients with cartilage diseases whose severity ranged from mild to lethal [1].

Anatomical context of Cartilage Diseases

• Similar to an animal model such human B cells may be induced by the exogenous antigen (HSP60) and crossreact with local auto-antigens related to the disease (cartilage) [9].
• Basic FGF may prove useful in articular cartilage repair, while basic FGF, IGFs and TGF-beta are among a number of growth factors and cytokines that have been implicated in cartilage disease [10].

Gene context of Cartilage Diseases

• IGFBP-3 levels are increased in degenerative cartilage diseases such as osteoarthritis [11].

References