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MeSH Review

Cartilage Diseases

 
 
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Disease relevance of Cartilage Diseases

 

High impact information on Cartilage Diseases

  • Hence, the EP2 agonist may be a potent therapeutic agent for degenerative cartilage diseases [3].
  • The goal is to stimulate critical thought and discussion in the field about cartilage fibronectin isoforms, their function(s) in normal cartilage, and their role(s) in the pathogenesis of cartilage diseases [4].
  • A more complete understanding of the role of TGF-beta and its down-stream signals will lead to improved understanding and treatment of cartilage diseases [5].
  • DDP is a potential indicator of cartilage metabolism during normal growth, ageing, and cartilage disease [6].
  • Our findings point to a pathological role for serine proteinase(s) in the development of cartilage diseases such as arthritis, possibly in a cascade which results in the activation of the enzyme(s) directly responsible for proteoglycan breakdown [7].
 

Chemical compound and disease context of Cartilage Diseases

 

Biological context of Cartilage Diseases

 

Anatomical context of Cartilage Diseases

 

Gene context of Cartilage Diseases

References

  1. Identification of COL2A1 gene mutations in patients with chondrodysplasias and familial osteoarthritis. Ritvaniemi, P., Körkkö, J., Bonaventure, J., Vikkula, M., Hyland, J., Paassilta, P., Kaitila, I., Kääriäinen, H., Sokolov, B.P., Hakala, M. Arthritis Rheum. (1995) [Pubmed]
  2. Characteristics and performance of an immunosorbent assay for human matrix Gla-protein. Schurgers, L.J., Teunissen, K.J., Knapen, M.H., Geusens, P., van der Heijde, D., Kwaijtaal, M., van Diest, R., Ketteler, M., Vermeer, C. Clin. Chim. Acta (2005) [Pubmed]
  3. PGE2 signal through EP2 promotes the growth of articular chondrocytes. Aoyama, T., Liang, B., Okamoto, T., Matsusaki, T., Nishijo, K., Ishibe, T., Yasura, K., Nagayama, S., Nakayama, T., Nakamura, T., Toguchida, J. J. Bone Miner. Res. (2005) [Pubmed]
  4. Cartilage fibronectin isoforms: in search of functions for a special population of matrix glycoproteins. Burton-Wurster, N., Lust, G., Macleod, J.N. Matrix Biol. (1997) [Pubmed]
  5. Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo. Ferguson, C.M., Schwarz, E.M., Puzas, J.E., Zuscik, M.J., Drissi, H., O'Keefe, R.J. J. Orthop. Res. (2004) [Pubmed]
  6. Novel fluorescent compound (DDP) in calf, rabbit, and human articular cartilage and synovial fluid. Gahunia, H.K., Vieth, R., Pritzker, K. J. Rheumatol. (2002) [Pubmed]
  7. A serine proteinase inactivator inhibits chondrocyte-mediated cartilage proteoglycan breakdown occurring in response to proinflammatory cytokines. Bryson, H., Bunning, R.A., Feltell, R., Kam, C.M., Kerrigan, J., Powers, J.C., Buttle, D.J. Arch. Biochem. Biophys. (1998) [Pubmed]
  8. Malignant hypophosphathaemic bone disease. Kozlowski, K., Posen, S. European journal of radiology. (2001) [Pubmed]
  9. Monoclonal autoantibodies from patients with autoimmune diseases: specificity, affinity and crossreactivity of MAbs binding to cytoskeletal and nucleolar epitopes, cartilage antigens and mycobacterial heat-shock protein 60. Menge, T., Rzepka, R., Melchers, I. Immunobiology (2002) [Pubmed]
  10. Peptide growth factors and their interactions during chondrogenesis. Hill, D.J., Logan, A. Prog. Growth Factor Res. (1992) [Pubmed]
  11. Cartilage disorders: potential therapeutic use of mesenchymal stem cells. Spagnoli, A., Longobardi, L., O'Rear, L. Endocrine development. (2005) [Pubmed]
 
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