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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Heart Conduction System

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Disease relevance of Heart Conduction System

  • In contrast, the VACT in patients with WPW syndrome remained unchanged during ventricular pacing at rates of 145/min and more before and after atropine, indicating the retrograde conduction was taking place through the Kent bundle [1].

High impact information on Heart Conduction System


Associations of Heart Conduction System with chemical compounds

  • Flecainide plasma concentrations correlated to inhibition of a bundle of Kent [7].
  • A histochemical study of some enzymes of glucose metabolism was performed on the heart conduction system of rat, dog, rabbit, pig, calf and lamb [8].
  • The dangerous form of WPW (rapid conduction in the Kent bundle > 240/min in the control state or > 300/min after isoproterenol + AF induction) occurred, respectively, in 3 (21%), 9 (27%), 4 (27%), 1 (6%), and 3 (23%) patients [9].
  • Atropine influence was negative on QRS complex of pattern W i2 cases showing the co-existence of Kent bundle and James fibers or exclusive Kent bundle conduction [10].

Gene context of Heart Conduction System


  1. The effect of atropine on ventriculoatrial conduction during ventricular pacing in patients with and without Wolff-Parkinson-White syndrome. Ito, M., Shinoda, S., Nagashima, M., Furuta, T., Tokudome, T., Otaki, M., Suzuki, H. Tohoku J. Exp. Med. (1977) [Pubmed]
  2. The anatomic substrate for preexcitation in corrected transposition. Bharati, S., Rosen, K., Steinfield, L., Miller, R.A., Lev, M. Circulation (1980) [Pubmed]
  3. Increased immunoexpression of atrial natriuretic peptide in the heart conduction system of the rat after cardiac sympathectomy. Hansson, M., Kjörell, U., Forsgren, S. J. Mol. Cell. Cardiol. (1998) [Pubmed]
  4. Neuropeptide Y-like immunoreactivity in relation to the distribution of sympathetic nerve fibers in the heart conduction system. Forsgren, S. J. Mol. Cell. Cardiol. (1989) [Pubmed]
  5. Atrial natriuretic peptide in the innervation of the bovine heart conduction system: relationship with substance P and autonomic innervation--immunohistochemical studies. Hansson, M., Forsgren, S. Neurosci. Lett. (1994) [Pubmed]
  6. Localization of angiotensin AT1 receptors in the rat heart conduction system. Saavedra, J.M., Viswanathan, M., Shigematsu, K. Eur. J. Pharmacol. (1993) [Pubmed]
  7. Flecainide plasma concentrations correlated to inhibition of a bundle of Kent. Casiglia, E., Martines, C., Moretto, R., Piovan, D. British journal of clinical pharmacology. (1987) [Pubmed]
  8. A comparative enzyme histochemical study of glucose metabolism in the conduction system of mammalian hearts. Gabrielli, F., Aita, M., Arturi, E., Alcini, E. Cell. Mol. Biol. (1992) [Pubmed]
  9. Influence of age on the potential risk of sudden death in asymptomatic Wolff-Parkinson-White syndrome. Brembilla-Perrot, B., Holban, I., Houriez, P., Claudon, O., Beurrier, D., Vançon, A.C. Pacing and clinical electrophysiology : PACE. (2001) [Pubmed]
  10. The effects of atropine on atrio-ventricular conduction in patients with Wolff-Parkinson-White syndrome. Studies with His bundle electrogram. Ito, M. Jpn. Circ. J. (1976) [Pubmed]
  11. The surgical treatment of Wolff-Parkinson-White Syndrome: evolution of improved methods for identification and interruption of the Kent Bundle. Sealy, W.C., Gallagher, J.J., Wallace, A.G. Ann. Thorac. Surg. (1976) [Pubmed]
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