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Gene Review

NPPA  -  natriuretic peptide A

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Disease relevance of NPPA


High impact information on NPPA

  • This hormone, described in 1981 as atrial natriuretic factor (ANF), is diuretic (natriuretic), hypotensive, and has an inhibitory effect on renin and aldosterone secretion [6].
  • Our results indicate that ANP and BNP can stimulate CNP production through a guanylate cyclase receptor on endothelial cells [7].
  • The enhanced production and secretion of CNP, caused by either ANP or BNP, was significantly prevented by LY 83583, an inhibitor of cGMP generation, and was also attenuated by KT 5823, an inhibitor of cGMP-dependent protein kinase [7].
  • Transfection of the ANP vector decreased DNA synthesis in VSMC under basal and angiotensin II-stimulated conditions [1].
  • Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth [1].

Chemical compound and disease context of NPPA

  • Levels of pertussis toxin sufficient to inhibit subsequent in vitro ribosylation did not significantly alter the ANP effect on aldosterone production, although a partial reduction in the ANP effect on cAMP levels was observed.(ABSTRACT TRUNCATED AT 400 WORDS)[8]
  • Effect of the ANF analog A68828 in cisplatin-induced acute renal failure [9].
  • Pertussis toxin (PTX; 200 ng/ml for 18 h) augmented the relaxation and accumulation of guanosine 3',5'-cyclic monophosphate produced by ANP [10].
  • The inhibitory effect of ANP on Tg mRNA level was reverted in the presence of pertussis toxin, an inhibitor of the G(i)-protein-mediated reduction of the adenylate cyclase activity [11].
  • Original studies with rat adrenocortical carcinoma identified a 180 kDa cell-surface protein which contained both guanylate cyclase and atrial natriuretic factor (ANF) receptor, representing a potentially new type of bifunctional receptor protein [12].

Biological context of NPPA


Anatomical context of NPPA


Associations of NPPA with chemical compounds


Regulatory relationships of NPPA


Other interactions of NPPA


Analytical, diagnostic and therapeutic context of NPPA


  1. Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth. Morishita, R., Gibbons, G.H., Pratt, R.E., Tomita, N., Kaneda, Y., Ogihara, T., Dzau, V.J. J. Clin. Invest. (1994) [Pubmed]
  2. Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. Ohno, M., Gibbons, G.H., Dzau, V.J., Cooke, J.P. Circulation (1993) [Pubmed]
  3. Gene expression and synthesis of natriuretic peptides by cultured human glomerular cells. Lai, K.N., Leung, J.C., Yandle, T.G., Fisher, S., Nicholls, M.G. J. Hypertens. (1999) [Pubmed]
  4. Oxygen modulation of guanylate cyclase-mediated retinal pericyte relaxations with 3-morpholino-sydnonimine and atrial natriuretic peptide. Haefliger, I.O., Anderson, D.R. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  5. Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation. Ni, X.P., Safai, M., Gardner, D.G., Humphreys, M.H. Kidney Int. (2001) [Pubmed]
  6. Atrial natriuretic factor: a hormone produced by the heart. de Bold, A.J. Science (1985) [Pubmed]
  7. Atrial and brain natriuretic peptides stimulate the production and secretion of C-type natriuretic peptide from bovine aortic endothelial cells. Nazario, B., Hu, R.M., Pedram, A., Prins, B., Levin, E.R. J. Clin. Invest. (1995) [Pubmed]
  8. High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells. MacFarland, R.T., Zelus, B.D., Beavo, J.A. J. Biol. Chem. (1991) [Pubmed]
  9. Effect of the ANF analog A68828 in cisplatin-induced acute renal failure. Pollock, D.M., Holst, M., Opgenorth, T.J. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  10. Stimulation of muscarinic M2 receptors inhibits atrial natriuretic peptide-mediated relaxation in bovine tracheal smooth muscle. Nakahara, T., Yunoki, M., Mitani, A., Sakamoto, K., Ishii, K. Naunyn Schmiedebergs Arch. Pharmacol. (2002) [Pubmed]
  11. Atrial natriuretic peptide inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles. Costamagna, M.E., Coleoni, A.H., Pellizas, C.G., Cabanillas, A.M., Vélez, M.L., Masini-Repiso, A.M. Regul. Pept. (2002) [Pubmed]
  12. Ubiquitous and bifunctional 180 kDa atrial natriuretic factor-dependent guanylate cyclase. Marala, R.B., Sharma, R.K. Mol. Cell. Biochem. (1991) [Pubmed]
  13. Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide. Pedram, A., Razandi, M., Levin, E.R. J. Biol. Chem. (2002) [Pubmed]
  14. Structure and analysis of the bovine atrial natriuretic peptide precursor gene. Vlasuk, G.P., Miller, J., Bencen, G.H., Lewicki, J.A. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  15. A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells. Ardati, A., Nemer, M. EMBO J. (1993) [Pubmed]
  16. Purification and sequence determination of bovine atrial natriuretic factor. Ong, H., McNicoll, N., Lazure, C., Seidah, N., Chrétien, M., Cantin, M., De Léan, A. Life Sci. (1986) [Pubmed]
  17. Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of "vascular natriuretic peptide system". Suga, S., Nakao, K., Itoh, H., Komatsu, Y., Ogawa, Y., Hama, N., Imura, H. J. Clin. Invest. (1992) [Pubmed]
  18. Purification and subunit composition of atrial natriuretic peptide receptor. Schenk, D.B., Phelps, M.N., Porter, J.G., Fuller, F., Cordell, B., Lewicki, J.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  19. Specific binding of atrial natriuretic factor in brain microvessels. Chabrier, P.E., Roubert, P., Braquet, P. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  20. Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis. Nikolaev, V.O., Gambaryan, S., Engelhardt, S., Walter, U., Lohse, M.J. J. Biol. Chem. (2005) [Pubmed]
  21. Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells. Mediation through the C receptor. Hu, R.M., Levin, E.R., Pedram, A., Frank, H.J. J. Biol. Chem. (1992) [Pubmed]
  22. Atrial natriuretic peptide inhibits calcium-induced steroidogenic acute regulatory protein gene transcription in adrenal glomerulosa cells. Cherradi, N., Brandenburger, Y., Rossier, M.F., Vallotton, M.B., Stocco, D.M., Capponi, A.M. Mol. Endocrinol. (1998) [Pubmed]
  23. Modulation of the effect of atrial natriuretic peptide in human and bovine bronchi by phosphoramidon. Angus, R.M., Nally, J.E., McCall, R., Young, L.C., McGrath, J.C., Thomson, N.C. Clin. Sci. (1994) [Pubmed]
  24. Atrial natriuretic peptide reduces cyclic AMP by activating cyclic GMP-stimulated phosphodiesterase in vascular endothelial cells. Kishi, Y., Ashikaga, T., Watanabe, R., Numano, F. J. Cardiovasc. Pharmacol. (1994) [Pubmed]
  25. A variant form of the type C atrial natriuretic peptide receptor generated by alternative RNA splicing. Mizuno, T., Iwashina, M., Itakura, M., Hagiwara, H., Hirose, S. J. Biol. Chem. (1993) [Pubmed]
  26. Characterization by affinity cross-linking of a receptor for atrial natriuretic peptide in cultured human thyroid cells associated with reductions in both adenosine 3',5'-monophosphate production and thyroglobulin secretion. Tseng, Y.C., Lahiri, S., Sellitti, D.F., Burman, K.D., D'Avis, J.C., Wartofsky, L. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  27. Action of endogenous atrial natriuretic peptide in calves with experimental acute central venous congestion and low cardiac output. Rokitansky, A.M., Losert, U.M., Trubel, W., Wieselthaler, G., Krausler, S., Shreiner, W., Buxbaum, P., Vierhapper, H., Waldhäusl, W.K., Wolner, E. Cardiovasc. Res. (1990) [Pubmed]
  28. Atrial natriuretic peptide in bovine corpus luteum. Vollmar, A.M., Mytzka, C., Arendt, R.M., Schulz, R. Endocrinology (1988) [Pubmed]
  29. Molecular characterization of the solubilized atrial natriuretic factor receptor from bovine adrenal zona glomerulosa. Meloche, S., Ong, H., Cantin, M., De Léan, A. Mol. Pharmacol. (1986) [Pubmed]
  30. Coexistence of C-type natriuretic peptide and atrial natriuretic peptide systems in the bovine cornea. Kim, S.Z., Kim, H.S., Lee, K.S., Lee, S.J., Seul, K.H., Koh, G.Y., Cho, K.W., Kim, S.H. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
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