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High impact information on Radiochemistry


Biological context of Radiochemistry


Associations of Radiochemistry with chemical compounds

  • Rhodium-105 tetrathioether complexes: radiochemistry and initial biological evaluation [7].
  • Herein we describe the radiosynthesis of an (18)F-labelled resveratrol derivative, 3,5-dihydroxy-4'-[(18)F]fluoro-trans-stilbene ([(18)F]-1), using the Horner-Wadsworth-Emmons reaction as a novel radiolabelling technique in PET radiochemistry for subsequent functional imaging of polyphenol metabolism in vivo [8].
  • Nuclide migration and the environmental radiochemistry of Florida phosphogypsum [9].
  • The basic facility consists of a medical cyclotron (10 MeV proton & 5 MeV deuteron), six lead-shielded hotcells with associated radiochemistry facilities, radiopharmacy and a whole body PET scanner [10].
  • Technetium-99 m complexes of EDTA analogs: studies of the radiochemistry and biodistribution [11].

Gene context of Radiochemistry

  • In contrast to FDG/PET, this technique demands specialized radiochemistry, plasma analysis, and modeling approaches that currently restrict its applicability to a few research PET centers [12].
  • For example, PET imaging is very much a part of Nuclear Medicine now and its expected growth in the future, along with the accompanying cyclotron and radiochemistry complexities, may prove to be a very large bite for any other discipline to follow [13].
  • New production methods for NCA Pt, Ir, Au, Cu and Ga radiotracers are presented, with some details on radiochemistry and quality controls [14].


  1. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Meltzer, C.C., Smith, G., DeKosky, S.T., Pollock, B.G., Mathis, C.A., Moore, R.Y., Kupfer, D.J., Reynolds, C.F. Neuropsychopharmacology (1998) [Pubmed]
  2. Evidence for two distinct forms of fatty acid cyclooxygenase in brain. Lysz, T.W., Needleman, P. J. Neurochem. (1982) [Pubmed]
  3. Serotonin 5-HT1A receptor imaging in the human brain with PET. Co-ordination of the standardisation and dissemination of methodology. Workshop on [carbonyl-11C]WAY-100635 radiochemistry and metabolite analysis 30-31 March 1999. MRC Cyclotron Unit, London, UK. Pike, V.W. European journal of nuclear medicine. (1999) [Pubmed]
  4. Synthesis, radiochemistry and biological evaluation of a new somatostatin analogue (SDZ 219-387) labelled with technetium-99m. Maina, T., Stolz, B., Albert, R., Bruns, C., Koch, P., Mäcke, H. European journal of nuclear medicine. (1994) [Pubmed]
  5. Radiopharmaceutical chemistry for positron emission tomography. Elsinga, P.H. Methods (2002) [Pubmed]
  6. Radiopharmaceuticals for cardiac imaging. Miller, D.D., Elmaleh, D.R., McKusick, K.A., Boucher, C.A., Callahan, R.J., Strauss, H.W. Radiol. Clin. North Am. (1985) [Pubmed]
  7. Rhodium-105 tetrathioether complexes: radiochemistry and initial biological evaluation. Goswami, N., Higginbotham, C., Volkert, W., Alberto, R., Nef, W., Jurisson, S. Nucl. Med. Biol. (1999) [Pubmed]
  8. Synthesis and biodistribution of an (18)F-labelled resveratrol derivative for small animal positron emission tomography. Gester, S., Wuest, F., Pawelke, B., Bergmann, R., Pietzsch, J. Amino Acids (2005) [Pubmed]
  9. Nuclide migration and the environmental radiochemistry of Florida phosphogypsum. Burnett, W.C., Elzerman, A.W. Journal of environmental radioactivity. (2001) [Pubmed]
  10. Positron emission tomography: radioisotope and radiopharmaceutical production. Tochon-Danguy, H.J., Sachinidis, J.I., Egan, G.F., Chan, J.G., Berlangieri, S.U., McKay, W.J., Scott, A.M. Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine. (1999) [Pubmed]
  11. Technetium-99 m complexes of EDTA analogs: studies of the radiochemistry and biodistribution. Baker, R.J., Diamanti, C.I., Goodwin, D.A., Meares, C.F. International journal of nuclear medicine and biology. (1981) [Pubmed]
  12. Positron emission tomography studies in parkinsonism. Eidelberg, D. Neurologic clinics. (1992) [Pubmed]
  13. Whither, or wither nuclear medicine? MacIntyre, W.J., Go, R.T. Administrative radiology : AR. (1991) [Pubmed]
  14. "High specific activity" radiotracers for metallo-toxicological studies: cyclotron and nuclear reactor production, radiochemical separation and "quality control": platinum, iridium, gold, copper and gallium. Bonardi, M., Groppi, F., Birattari, C., Arginelli, D. Annali di chimica. (2002) [Pubmed]
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