High impact information on Radiochemistry

• However, recent advances in PET radiochemistry, instrumentation, and image processing have paved the way for noninvasive means to test specific hypotheses regarding the direct involvement of 5-HT neurons in the behavioral features of aging and to define and monitor therapeutic regimens for neuropsychiatric conditions of late life [1].
• Prostaglandin E2 (PGE2) levels, measured either by radiochemistry or radioimmunoassay, rose rapidly and abruptly plateaued within 5 min, while prostaglandin F2 alpha (PGF2 alpha) levels continued to rise for 30 min [2].
• Serotonin 5-HT1A receptor imaging in the human brain with PET. Co-ordination of the standardisation and dissemination of methodology. Workshop on [carbonyl-11C]WAY-100635 radiochemistry and metabolite analysis 30-31 March 1999. MRC Cyclotron Unit, London, UK [3].
• Synthesis, radiochemistry and biological evaluation of a new somatostatin analogue (SDZ 219-387) labelled with technetium-99m [4].
• These aspects include production of fluorine-18 and carbon-11, workup of fluorine-18, (18)F radiochemistry, production of [(11)C]methyl iodide and triflate, and (11)C-methylation radiochemistry [5].

Biological context of Radiochemistry

• The radiochemistry and dosimetry of and clinical experience with these new agents are summarized, and are compared with more widely used methods for assessing myocardial perfusion (thallium-201 scintigraphy) and ventricular function (technetium-99m radioangiography) [6].

Associations of Radiochemistry with chemical compounds

• Rhodium-105 tetrathioether complexes: radiochemistry and initial biological evaluation [7].
• Herein we describe the radiosynthesis of an (18)F-labelled resveratrol derivative, 3,5-dihydroxy-4'-[(18)F]fluoro-trans-stilbene ([(18)F]-1), using the Horner-Wadsworth-Emmons reaction as a novel radiolabelling technique in PET radiochemistry for subsequent functional imaging of polyphenol metabolism in vivo [8].
• Nuclide migration and the environmental radiochemistry of Florida phosphogypsum [9].
• The basic facility consists of a medical cyclotron (10 MeV proton & 5 MeV deuteron), six lead-shielded hotcells with associated radiochemistry facilities, radiopharmacy and a whole body PET scanner [10].
• Technetium-99 m complexes of EDTA analogs: studies of the radiochemistry and biodistribution [11].

Gene context of Radiochemistry

• In contrast to FDG/PET, this technique demands specialized radiochemistry, plasma analysis, and modeling approaches that currently restrict its applicability to a few research PET centers [12].
• For example, PET imaging is very much a part of Nuclear Medicine now and its expected growth in the future, along with the accompanying cyclotron and radiochemistry complexities, may prove to be a very large bite for any other discipline to follow [13].
• New production methods for NCA Pt, Ir, Au, Cu and Ga radiotracers are presented, with some details on radiochemistry and quality controls [14].

References