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MeSH Review

Neoplasms, Muscle Tissue

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Disease relevance of Neoplasms, Muscle Tissue


High impact information on Neoplasms, Muscle Tissue

  • Expression of androgen receptors in five mammary myofibroblastomas in both sexes [4].
  • Given the demographics of this lesion, the established trophic effect of steroid hormones, and the potential diagnostic utility of hormone receptor analysis in differentiating spindle cell tumors, we immunohistochemically tested for estrogen and androgen receptors in a host of spindle cell lesions including myofibroblastoma of the breast [5].
  • We postulate that the androgen receptor or its ligands may be pathologically related to the development of myofibroblastoma of the breast and diagnostically useful in differentiating it from other spindle cell lesions [5].
  • The central portion resembled mammary myofibroblastoma or solitary fibrous tumor of other sites and showed reactivity for CD34 and muscle-specific actin, with few cells staining for desmin [6].
  • Although closely related to solitary fibrous tumor, mammary myofibroblastoma appears slightly different because of its consistent slant toward myoid differentiation in the form of actin and variable desmin reactivity as opposed to the rare and sparse immunohistochemical expression of myoid features by solitary fibrous tumors of other sites [6].

Chemical compound and disease context of Neoplasms, Muscle Tissue


Gene context of Neoplasms, Muscle Tissue

  • Intranodal palisaded myofibroblastoma with overexpression of cyclin D1 [8].
  • The latter subtype, comprised nine cases exhibiting evidence of myofibroblastic differentiation (desmin and alpha-smooth muscle actin) which were classified as myofibroblastomas (MFBs) [9].
  • Intranodal palisaded myofibroblastoma is thought to arise from intranodal myofibroblasts, a finding that is supported by its immunophenotype, positive immunostaining for actin and vimentin, and negative immunostaining for desmin [10].


  1. Prolapse of the fallopian tube after hysterectomy associated with exuberant angiomyofibroblastic stroma response: a diagnostic pitfall. Michal, M., Rokyta, Z., Mejchar, B., Pelikan, K., Kummel, M., Mukensnabl, P. Virchows Arch. (2000) [Pubmed]
  2. Fibromatosis of the breast: age-correlated morphofunctional features of 33 cases. Devouassoux-Shisheboran, M., Schammel, M.D., Man, Y.G., Tavassoli, F.A. Arch. Pathol. Lab. Med. (2000) [Pubmed]
  3. Central odontogenic fibroma, granular cell variant. A case report with S-100 immunohistochemistry and a review of the literature. Shiro, B.C., Jacoway, J.R., Mirmiran, S.A., McGuirt, W.F., Siegal, G.P. Oral Surg. Oral Med. Oral Pathol. (1989) [Pubmed]
  4. Expression of androgen receptors in five mammary myofibroblastomas in both sexes. Silverman, J.S., Hamilton, J., Tamsen, A. Hum. Pathol. (1999) [Pubmed]
  5. Myofibroblastoma of the breast revisited: an etiologic association with androgens? Morgan, M.B., Pitha, J.V. Hum. Pathol. (1998) [Pubmed]
  6. Mammary myofibroblastoma with leiomyomatous differentiation. Thomas, T.M., Myint, A., Mak, C.K., Chan, J.K. Am. J. Clin. Pathol. (1997) [Pubmed]
  7. Granular cell variants in a rat schwannoma. Evidence of neurogenic origin of granular cell tumor (myoblastoma). Berman, J.J., Rice, J.M., Strandberg, J. Vet. Pathol. (1978) [Pubmed]
  8. Intranodal palisaded myofibroblastoma with overexpression of cyclin D1. Kleist, B., Poetsch, M., Schmoll, J. Arch. Pathol. Lab. Med. (2003) [Pubmed]
  9. Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept. Magro, G., Bisceglia, M., Michal, M., Eusebi, V. Virchows Arch. (2002) [Pubmed]
  10. Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation. Creager, A.J., Garwacki, C.P. Arch. Pathol. Lab. Med. (1999) [Pubmed]
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