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MeSH Review

Granular Cell Tumor

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Disease relevance of Granular Cell Tumor


High impact information on Granular Cell Tumor


Chemical compound and disease context of Granular Cell Tumor


Biological context of Granular Cell Tumor

  • Unlike the usual granular cell tumors arising in the tongue or buccal mucosa, such lesions are not S-100 positive and can exhibit mitoses and cytologic atypia, features that may suggest a low-grade mesenchymal malignancy necessitating aggressive therapy [16].

Anatomical context of Granular Cell Tumor


Gene context of Granular Cell Tumor

  • Immunoperoxidase staining using five antisera to human carcinoembryonic antigen (CEA), including a mouse monoclonal antibody, was performed to investigate the expression of CEA reactivity in ten cases of granular cell myoblastoma [21].
  • Thirty-one granular cell lesions (26 granular cell tumors [GCT] and five other granular cell lesions) from 18 different sites were evaluated immunohistochemically for keratins, vimentin, desmin, muscle actin, ACT, HLA-DR, and S-100 protein [22].
  • Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation [23].
  • Granular cell tumor in a PHTS patient with a novel germline PTEN mutation [24].
  • For further characterization of S-100 protein-positive granular cell tumor (GCT), the expression of osteopontin (OPN) in the tumor cells was compared with other types of Schwannian cell tumors [25].

Analytical, diagnostic and therapeutic context of Granular Cell Tumor


  1. Immunohistochemical detection of epithelial membrane antigen in normal perineurial cells and perineurioma. Ariza, A., Bilbao, J.M., Rosai, J. Am. J. Surg. Pathol. (1988) [Pubmed]
  2. Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. Weiss, S.W., Langloss, J.M., Enzinger, F.M. Lab. Invest. (1983) [Pubmed]
  3. A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center. Kim, D.H., Murovic, J.A., Tiel, R.L., Moes, G., Kline, D.G. J. Neurosurg. (2005) [Pubmed]
  4. Correlation of carcinoembryonic antigen in tissue sections with spread of mammary carcinoma. Shousha, S., Lyssiotis, T. Histopathology (1978) [Pubmed]
  5. Congenital granular cell epulis. Immunohistochemical and ultrastructural observations. Lifshitz, M.S., Flotte, T.J., Greco, M.A. Cancer (1984) [Pubmed]
  6. FDG PET evaluation of granular cell tumor of the breast. Hoess, C., Freitag, K., Kolben, M., Allgayer, B., Laemmer-Skarke, I., Nathrath, W.B., Avril, N., Roemer, W., Schwaiger, M., Graeff, H. J. Nucl. Med. (1998) [Pubmed]
  7. Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. Fine, S.W., Li, M. Am. J. Clin. Pathol. (2003) [Pubmed]
  8. Malignant granular cell tumor metastatic to the orbit. Callejo, S.A., Kronish, J.W., Decker, S.J., Cohen, G.R., Rosa, R.H. Ophthalmology (2000) [Pubmed]
  9. Malignant granular cell tumor: a case report and review of the recent literature. Simsir, A., Osborne, B.M., Greenebaum, E. Hum. Pathol. (1996) [Pubmed]
  10. Immunoreactivity of S100 protein, alpha-1-antitrypsin, and CD68 in adult and congenital granular cell tumors. Filie, A.C., Lage, J.M., Azumi, N. Mod. Pathol. (1996) [Pubmed]
  11. Treatment of granular cell tumor of the esophagus by endoscopic injection of dehydrated alcohol. Moreira, L.S., Dani, R. Am. J. Gastroenterol. (1992) [Pubmed]
  12. Granular cell tumors of the tracheobronchial tree. van der Maten, J., Blaauwgeers, J.L., Sutedja, T.G., Kwa, H.B., Postmus, P.E., Wagenaar, S.S. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  13. Congenital granular-cell myoblastoma. Cussen, L.J., MacMahon, R.A. J. Pediatr. Surg. (1975) [Pubmed]
  14. Endosonographic features of esophageal granular cell tumors. Palazzo, L., Landi, B., Cellier, C., Roseau, G., Chaussade, S., Couturier, D., Barbier, J. Endoscopy. (1997) [Pubmed]
  15. Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein. Ingram, D.L., Mossler, J.A., Snowhite, J., Leight, G.S., McCarty, K.S. Arch. Pathol. Lab. Med. (1984) [Pubmed]
  16. Polypoid S-100-negative granular cell tumor of the oral cavity: a case report and review of literature. Basile, J.R., Woo, S.B. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2003) [Pubmed]
  17. Granular cell tumor of the stomach coincident with two early gastric carcinomas. Yamaguchi, K., Maeda, S., Kitamura, K. Am. J. Gastroenterol. (1989) [Pubmed]
  18. Alveolar soft-part sarcoma. A review on its histogenesis and further studies based on electron microscopy, immunohistochemistry, and biochemistry. Mukai, M., Iri, H., Nakajima, T., Hirose, S., Torikata, C., Kageyama, K., Ueno, N., Murakami, K. Am. J. Surg. Pathol. (1983) [Pubmed]
  19. Granular cell tumor of the thyroid gland in a girl receiving high-dose estrogen therapy. Mahoney, C.P., Patterson, S.D., Ryan, J. Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association. (1995) [Pubmed]
  20. Expression of intermediate filaments and stromal proteins in granular cell tumor of the tongue. Ophir, D., Lifschitz-Mercer, B., Czernobilsky, B. Oral Surg. Oral Med. Oral Pathol. (1988) [Pubmed]
  21. Granular cell myoblastoma: an immunoperoxidase study using a variety of antisera to human carcinoembryonic antigen. Matthews, J.B., Mason, G.I. Histopathology (1983) [Pubmed]
  22. Immunoreactivity of granular cell lesions of skin, mucosa, and jaw. Regezi, J.A., Zarbo, R.J., Courtney, R.M., Crissman, J.D. Cancer (1989) [Pubmed]
  23. Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. Le, B.H., Boyer, P.J., Lewis, J.E., Kapadia, S.B. Arch. Pathol. Lab. Med. (2004) [Pubmed]
  24. Granular cell tumor in a PHTS patient with a novel germline PTEN mutation. Marchese, C., Montera, M., Torrini, M., Goldoni, F., Mareni, C., Forni, M., Locatelli, L. Am. J. Med. Genet. A (2003) [Pubmed]
  25. Regular expression of osteopontin in granular cell tumor: distinctive feature among Schwannian cell tumors. Hoshi, N., Sugino, T., Suzuki, T. Pathol. Int. (2005) [Pubmed]
  26. Absence of myelin basic protein in granular cell tumors. Osborne, P.T., Giltman, L.I., Jennings, B.R., McClellan, G. Acta Neuropathol. (1987) [Pubmed]
  27. Mohs micrographic surgery for granular cell tumor using S-100 immunostain. Smith, S.B., Farley, M.F., Albertini, J.G., Elston, D.M. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2002) [Pubmed]
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