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Disease relevance of Fibroma


Psychiatry related information on Fibroma


High impact information on Fibroma

  • Overexpression of junB or c-jun by transfection into the mild fibromatosis stage elicited changes in cell shape and anchorage independence, whereas junD did not [6].
  • I investigated whether and how actin subunits exchange in this region by microinjecting living gerbil fibroma cells (IMR-33) with actin that had been labeled with iodoacetamidotetramethylrhodamine [7].
  • In the stress fibers of two types of nonmuscle cells, epithelia (PtK2, bovine lens) and fibroblasts (Gerbil fibroma, WI-38, primary human) the spacing between sites of alpha-actinin localization differs by a factor of about 1.6 as determined by indirect immunofluorescence and ultrastructural localization with peroxidase-labeled antibody [8].
  • Periodic densities spaced at comparable distances are seen in PtK2 and in gerbil fibroma cells when they are treated with tannic acid and examined in the electron microscope [8].
  • The structural data also allow molecular interpretation of known CMG2 VWA domain mutations linked to the genetic disorders, juvenile hyaline fibromatosis, and infantile systemic hyalinosis [9].

Chemical compound and disease context of Fibroma

  • The specificity and stability of the triton-extracted cytoskeletal framework of gerbil fibroma cells [10].
  • Effects of transforming growth factor-beta1 and tumour necrosis factor-alpha on cultured fibroblasts from skin fibroma as modulated by toremifene [11].
  • Following the NMR experiment, tumors were chemically assayed for lactate giving 8.17, 9.1, and 6.73 mumols/g wet wt for RIF-1, EMT6, and fibroma, respectively [12].
  • In the STI571 (Gleevec, Imatinib) era, the problem may be further compounded when protocol-driven staining for CD117 (c-kit) is performed on spindle cell proliferations presenting in the bowel wall and mesentery using an antibody known to react with the majority of mesenteric fibromatoses when other antibodies are more specific [13].
  • The antibody 6B6 raised against dermatan sulphate PG obtained from an ovarian fibroma capsule in our laboratory was also used [14].

Biological context of Fibroma


Anatomical context of Fibroma


Gene context of Fibroma

  • Hypermethylation of the BAMBI promoter was observed in microdissected tissue from the ossifying focus but not in that from the typical desmoid-type fibromatosis [19].
  • Important diagnostic criteria for TSC include facial angiofibromas, ungual fibromas, retinal hamartomas, and cortical tubers [24].
  • Median VEGF concentration is given in pg/mg protein (25%-quantile-75%-quantile) and it was 0 (0-1.8) in normal breast tissue, 9.8 (0.52-43.0) in fibromas and 130.4 (50.8-362.2) in invasive carcinomas [25].
  • All 21 examples of deep fibromatosis displayed nuclear beta-catenin (focal nuclear staining in one case to 90% staining) [26].
  • Nuchal-type fibroma is positive for CD34 and CD99 [27].

Analytical, diagnostic and therapeutic context of Fibroma


  1. MCP-1 overexpressed in tuberous sclerosis lesions acts as a paracrine factor for tumor development. Li, S., Takeuchi, F., Wang, J.A., Fuller, C., Pacheco-Rodriguez, G., Moss, J., Darling, T.N. J. Exp. Med. (2005) [Pubmed]
  2. Transforming growth factor beta 2 in epithelial differentiation of developing teeth and odontogenic tumors. Heikinheimo, K., Happonen, R.P., Miettinen, P.J., Ritvos, O. J. Clin. Invest. (1993) [Pubmed]
  3. Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1S by a myxoma virus serine proteinase inhibitor. Lomas, D.A., Evans, D.L., Upton, C., McFadden, G., Carrell, R.W. J. Biol. Chem. (1993) [Pubmed]
  4. Identification of a large insertion and two novel point mutations (3671del8 and S1221X) in tuberous sclerosis complex (TSC) patients. Mutations in brief no. 119. Online. Wang, Q., Verhoef, S., Tempelaars, A.M., Bakker, P.L., Vrtel, R., Hesseling-Janssen, A.L., Nellist, M., Oranje, A.P., Stroink, H., Lindhout, D., Halley, D.J., van den Ouweland, A.M. Hum. Mutat. (1998) [Pubmed]
  5. Intermediate filaments cytokeratin and vimentin in ovarian sex cord-stromal tumours with correlative studies in adult and fetal ovaries. Benjamin, E., Law, S., Bobrow, L.G. J. Pathol. (1987) [Pubmed]
  6. Transcription factors junB and c-jun are selectively up-regulated and functionally implicated in fibrosarcoma development. Bossy-Wetzel, E., Bravo, R., Hanahan, D. Genes Dev. (1992) [Pubmed]
  7. Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling. Wang, Y.L. J. Cell Biol. (1985) [Pubmed]
  8. Differences in the stress fibers between fibroblasts and epithelial cells. Sanger, J.W., Sanger, J.M., Jockusch, B.M. J. Cell Biol. (1983) [Pubmed]
  9. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Lacy, D.B., Wigelsworth, D.J., Scobie, H.M., Young, J.A., Collier, R.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  10. The specificity and stability of the triton-extracted cytoskeletal framework of gerbil fibroma cells. Gilbert, M., Fulton, A.B. J. Cell. Sci. (1985) [Pubmed]
  11. Effects of transforming growth factor-beta1 and tumour necrosis factor-alpha on cultured fibroblasts from skin fibroma as modulated by toremifene. Lilli, C., Marinucci, L., Bellocchio, S., Ribatti, D., Balducci, C., Baroni, T., Cagini, L., Giustozzi, G., Locci, P. Int. J. Cancer (2002) [Pubmed]
  12. A double quantum coherence transfer proton NMR spectroscopy technique for monitoring steady-state tumor lactic acid levels in vivo. Freeman, D.M., Sotak, C.H., Muller, H.H., Young, S.W., Hurd, R.E. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1990) [Pubmed]
  13. Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritis. Montgomery, E., Torbenson, M.S., Kaushal, M., Fisher, C., Abraham, S.C. Am. J. Surg. Pathol. (2002) [Pubmed]
  14. Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans in tumour tissues. Fukatsu, T., Sobue, M., Nagasaka, T., Ohiwa, N., Fukata, S., Nakashima, N., Takeuchi, J. Br. J. Cancer (1988) [Pubmed]
  15. Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). Tolg, C., Poon, R., Fodde, R., Turley, E.A., Alman, B.A. Oncogene (2003) [Pubmed]
  16. Chondromyxoid fibroma resembles in vitro chondrogenesis, but differs in expression of signalling molecules. Romeo, S., Bovée, J.V., Grogan, S.P., Taminiau, A.H., Eilers, P.H., Cleton-Jansen, A.M., Mainil-Varlet, P., Hogendoorn, P.C. J. Pathol. (2005) [Pubmed]
  17. Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors? Tsuji, T., Catasus, L., Prat, J. Hum. Pathol. (2005) [Pubmed]
  18. Fibrosarcoma versus cellular fibroma of the ovary: a comparative study of their proliferative activity and chromosome aberrations using MIB-1 immunostaining, DNA flow cytometry, and fluorescence in situ hybridization. Tsuji, T., Kawauchi, S., Utsunomiya, T., Nagata, Y., Tsuneyoshi, M. Am. J. Surg. Pathol. (1997) [Pubmed]
  19. Desmoid tumor with ossification in chest wall: possible involvement of BAMBI promoter hypermethylation in metaplastic bone formation. Kitazawa, S., Kitazawa, R., Obayashi, C., Yamamoto, T. J. Bone Miner. Res. (2005) [Pubmed]
  20. Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells. Liu, J., Kuulasmaa, T., Kosma, V.M., Bützow, R., Vänttinen, T., Hydén-Granskog, C., Voutilainen, R. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  21. Myofibroblasts of palmar fibromatosis co-express transforming growth factor-alpha and epidermal growth factor receptor. Magro, G., Lanteri, E., Micali, G., Paravizzini, G., Travali, S., Lanzafame, S. J. Pathol. (1997) [Pubmed]
  22. Somatostatin inhibits rapid centrosomal separation and cell proliferation induced by epidermal growth factor. Mascardo, R.N., Sherline, P. Endocrinology (1982) [Pubmed]
  23. Establishment of human cementifying fibroma cell lines by transfection with temperature-sensitive simian virus-40 T-antigen gene and hTERT gene. Kudo, Y., Hiraoka, M., Kitagawa, S., Miyauchi, M., Kakuo, S., Zhao, M., Ide, T., Takata, T. Bone (2002) [Pubmed]
  24. New developments in the neurobiology of the tuberous sclerosis complex. Crino, P.B., Henske, E.P. Neurology (1999) [Pubmed]
  25. Vascular endothelial growth factor (VEGF) in human breast cancer: correlation with disease-free survival. Obermair, A., Kucera, E., Mayerhofer, K., Speiser, P., Seifert, M., Czerwenka, K., Kaider, A., Leodolter, S., Kainz, C., Zeillinger, R. Int. J. Cancer (1997) [Pubmed]
  26. Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions. Bhattacharya, B., Dilworth, H.P., Iacobuzio-Donahue, C., Ricci, F., Weber, K., Furlong, M.A., Fisher, C., Montgomery, E. Am. J. Surg. Pathol. (2005) [Pubmed]
  27. Nuchal-type fibroma is positive for CD34 and CD99. Zamecnik, M., Michal, M. Am. J. Surg. Pathol. (2001) [Pubmed]
  28. An immunohistochemical study of metaplastic spindle cell carcinoma, phyllodes tumor and fibromatosis of the breast. Dunne, B., Lee, A.H., Pinder, S.E., Bell, J.A., Ellis, I.O. Hum. Pathol. (2003) [Pubmed]
  29. Evidence of ED-B+ fibronectin synthesis in human tissues by non-radioactive RNA in situ hybridization. Investigations on carcinoma (oral squamous cell and breast carcinoma), chronic inflammation (rheumatoid synovitis) and fibromatosis (Morbus Dupuytren). Berndt, A., Borsi, L., Luo, X., Zardi, L., Katenkamp, D., Kosmehl, H. Histochem. Cell Biol. (1998) [Pubmed]
  30. Endocrine therapy for desmoid tumors. Wilcken, N., Tattersall, M.H. Cancer (1991) [Pubmed]
  31. Cardiac fibroma mimicking apical hypertrophic cardiomyopathy: a case report and differential diagnosis. Veinot, J.P., O'Murchu, B., Tazelaar, H.D., Orszulak, T.A., Seward, J.B. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. (1996) [Pubmed]
  32. Role of technetium-99m pertechnetate scintigraphy in the management of extra-abdominal fibromatosis. Terui, S., Terauchi, T., Abe, H., Muramatsu, Y., Fukuma, H., Beppu, Y., Yokoyama, R. Skeletal radiology. (1995) [Pubmed]
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