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Chemical Compound Review

Reticuline     1-[(3-hydroxy-4-methoxy- phenyl)methyl]-6...

Synonyms: CHEMBL464734, SureCN147596, CHEBI:26533, AC1L1URK, LS-86186, ...
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Disease relevance of Reticulin


Psychiatry related information on Reticulin


High impact information on Reticulin


Chemical compound and disease context of Reticulin


Biological context of Reticulin


Anatomical context of Reticulin

  • Ex vivo studies demonstrated that TGF-beta1 significantly enhances the production and deposition of reticulin and collagen fibers by BM fibroblasts [1].
  • Our family study shows that healthy reticulin-antibody-positive first-degree relatives of coeliac disease patients, irrespective of the state of the jejunal mucosa, are genetically similar to known coeliac disease patients [3].
  • It is characterized by a sustained proliferation of megakaryocytes and increased medullary reticulin fibers [19].
  • We conclude that green light epifluorescence microscopy identifies extracellular deposits of eosinophil granules in bone marrow biopsies of some neoplastic disorders and in diseases associated with reticulin fibrosis [20].
  • After 3 to 4 months, polycythemia regressed, abnormally shaped red blood cells and platelets were seen in circulation, and a deposition of reticulin fibers was observed in marrow and spleen [21].

Associations of Reticulin with other chemical compounds


Gene context of Reticulin


Analytical, diagnostic and therapeutic context of Reticulin


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  2. Action of intensive cigarette smoke inhalations on the rat lung. Role of particulate and gaseous cofactors. Le Bouffant, L., Martin, J.C., Daniel, H., Henin, J.P., Normand, C. J. Natl. Cancer Inst. (1980) [Pubmed]
  3. Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease. Mäki, M., Holm, K., Lipsanen, V., Hällström, O., Viander, M., Collin, P., Savilahti, E., Koskimies, S. Lancet (1991) [Pubmed]
  4. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A., Gralnick, H.R., Sultan, C. Ann. Intern. Med. (1985) [Pubmed]
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  7. Distribution of a major connective tissue protein, fibronectin, in normal human tissues. Stenman, S., Vaheri, A. J. Exp. Med. (1978) [Pubmed]
  8. Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation. Halttunen, T., Mäki, M. Gastroenterology (1999) [Pubmed]
  9. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Sulkanen, S., Halttunen, T., Laurila, K., Kolho, K.L., Korponay-Szabó, I.R., Sarnesto, A., Savilahti, E., Collin, P., Mäki, M. Gastroenterology (1998) [Pubmed]
  10. Endogenous formation of morphine in human cells. Poeaknapo, C., Schmidt, J., Brandsch, M., Dräger, B., Zenk, M.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  11. Portal hypertension in acute liver failure. Navasa, M., Garcia-Pagán, J.C., Bosch, J., Riera, J.R., Bañares, R., Mas, A., Bruguera, M., Rodés, J. Gut (1992) [Pubmed]
  12. Epithelioid angiosarcoma of deep soft tissue: a distinctive tumor readily mistaken for an epithelial neoplasm. Fletcher, C.D., Beham, A., Bekir, S., Clarke, A.M., Marley, N.J. Am. J. Surg. Pathol. (1991) [Pubmed]
  13. Antibodies to gliadin, gluten and reticulin glycoprotein in rheumatic diseases: elevated levels in Sjögren's syndrome. Teppo, A.M., Maury, C.P. Clin. Exp. Immunol. (1984) [Pubmed]
  14. The degree of bone marrow fibrosis in chronic myelogenous leukemia is not a prognostic factor with imatinib mesylate therapy. Kantarjian, H.M., Bueso-Ramos, C.E., Talpaz, M., O'Brien, S., Giles, F., Rios, M.B., Shan, J., Cortes, J. Leuk. Lymphoma (2005) [Pubmed]
  15. RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy. Allen, R.S., Millgate, A.G., Chitty, J.A., Thisleton, J., Miller, J.A., Fist, A.J., Gerlach, W.L., Larkin, P.J. Nat. Biotechnol. (2004) [Pubmed]
  16. A variant form of hairy cell leukemia resistant to alpha-interferon: clinical and phenotypic characteristics of 17 patients. Sainati, L., Matutes, E., Mulligan, S., de Oliveira, M.P., Rani, S., Lampert, I.A., Catovsky, D. Blood (1990) [Pubmed]
  17. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Wernig, G., Mercher, T., Okabe, R., Levine, R.L., Lee, B.H., Gilliland, D.G. Blood (2006) [Pubmed]
  18. Karyotypic polymorphism in acute myelofibrosis. Shah, I., Mayeda, K., Koppitch, F., Mahmood, S., Nemitz, B. Blood (1982) [Pubmed]
  19. Clonal granulocytes and bone marrow cells in the cellular phase of agnogenic myeloid metaplasia. Kreipe, H., Jaquet, K., Felgner, J., Radzun, H.J., Parwaresch, M.R. Blood (1991) [Pubmed]
  20. Deposition of autofluorescent eosinophil granules in pathologic bone marrow biopsies. Samoszuk, M.K., Espinoza, F.P. Blood (1987) [Pubmed]
  21. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Lacout, C., Pisani, D.F., Tulliez, M., Gachelin, F.M., Vainchenker, W., Villeval, J.L. Blood (2006) [Pubmed]
  22. Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica. Morishige, T., Tsujita, T., Yamada, Y., Sato, F. J. Biol. Chem. (2000) [Pubmed]
  23. Some chemical principles applicable to some silver and gold staining methods for neuropathological studies. Feigin, I., Naoumenko, J. J. Neuropathol. Exp. Neurol. (1976) [Pubmed]
  24. (R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy. Ounaroon, A., Decker, G., Schmidt, J., Lottspeich, F., Kutchan, T.M. Plant J. (2003) [Pubmed]
  25. Nodular regenerative hyperplasia in partial hepatectomy specimens. Washington, K., Lane, K.L., Meyers, W.C. Am. J. Surg. Pathol. (1993) [Pubmed]
  26. Organization and relative content of smooth muscle cells, collagen and elastic fibers in the corpus cavernosum of rat penis. Pinheiro, A.C., Costa, W.S., Cardoso, L.E., Sampaio, F.J. J. Urol. (2000) [Pubmed]
  27. Deregulated expression of PAX5 in medulloblastoma. Kozmik, Z., Sure, U., Rüedi, D., Busslinger, M., Aguzzi, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  28. Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice. Chagraoui, H., Komura, E., Tulliez, M., Giraudier, S., Vainchenker, W., Wendling, F. Blood (2002) [Pubmed]
  29. Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: evidence for a medulloblastoma subtype derived from the external granule cell layer. Bühren, J., Christoph, A.H., Buslei, R., Albrecht, S., Wiestler, O.D., Pietsch, T. J. Neuropathol. Exp. Neurol. (2000) [Pubmed]
  30. Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies. Korponay-Szabó, I.R., Sulkanen, S., Halttunen, T., Maurano, F., Rossi, M., Mazzarella, G., Laurila, K., Troncone, R., Mäki, M. J. Pediatr. Gastroenterol. Nutr. (2000) [Pubmed]
  31. Vasculitis and expression of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin in salivary glands of patients with Sjögren's syndrome. Turkcapar, N., Sak, S.D., Saatci, M., Duman, M., Olmez, U. J. Rheumatol. (2005) [Pubmed]
  32. Reaction of human non-collagenous polypeptides with coeliac disease autoantibodies. Mäki, M., Hällström, O., Marttinen, A. Lancet (1991) [Pubmed]
  33. Pathology of lymphosarcoma in sheep induced with bovine leukemia virus. Olson, C., Baumgartener, L.E. Cancer Res. (1976) [Pubmed]
  34. Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease? Hirsch, E.C., Duyckaerts, C., Javoy-Agid, F., Hauw, J.J., Agid, Y. Ann. Neurol. (1990) [Pubmed]
  35. Neuronal migration defects in the Dreher (Lmx1a) mutant mouse: role of disorders of the glial limiting membrane. Costa, C., Harding, B., Copp, A.J. Cereb. Cortex (2001) [Pubmed]
  36. Does the reticulin binding property of cereal proteins demonstrable in vitro have pathogenetic significance for coeliac disease? Unsworth, D.J., Holborow, E.J. Gut (1985) [Pubmed]
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