Disease relevance of Coxsackievirus Infections

• Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy [1].
• We have previously shown that the production of these chemokines and cytokines in astrocytes is induced via the NF-kappaB pathway following TMEV and Coxsackie virus infection [2].
• These results indicate that cytokines may serve as prognostic markers in the therapy of infectious diseases and also that WIN 54954 and LS 2616 are both possible candidates for treatment of coxsackievirus infections in man [3].
• Studies that show an association between coxsackievirus infection and acute pancreatitis in humans are given additional support by the extensive data from mouse studies demonstrating that some serotypes (B4,B3) are tropic for the exocrine pancreas [4].

High impact information on Coxsackievirus Infections

• Dystrophin is also cleaved during Coxsackievirus infection of cultured myocytes and in infected mouse hearts, leading to impaired dystrophin function [5].
• The role of synaptic transmission in preventing susceptibility to Coxsackievirus infection was studied by surgically denervating leg muscles of mice or injecting the muscles with botulinum toxin to block quantal release of acetylcholine [6].
• Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry [7].
• RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection [8].
• Thus, NOS2 is a critical component in the immune response to Coxsackievirus infection [9].

Chemical compound and disease context of Coxsackievirus Infections

• Coxsackievirus infections in children and in infants are being treated with pleconaril with some efficacy in reducing mortality and improving recovery, albeit the treatment is often on a compassionate use basis [10].

Anatomical context of Coxsackievirus Infections

• We have now found that PABP is also proteolytically cleaved during coxsackievirus infection of HeLa cells [11].

Gene context of Coxsackievirus Infections

• A possible role of Coxsackie virus infection in the pathogenesis of idiopathic right ventricular myocardial hypoplasia in association with right ventricular dilatation in man (Uhl's anomaly) is discussed [12].
• CONCLUSION: To our knowledge, CAR-Fc is the only protein that has been shown to block coxsackievirus infection of the pancreas [13].
• dsRNA formed as an intermediate during Coxsackievirus infection does not induce NO production in a beta-cell line with or without addition of IFN-gamma [14].

References