Chemical Compound Review:
Linomide 2-hydroxy-N,1-dimethyl-4-oxo- N-phenyl...
Synonyms:
- Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents. Joseph, I.B., Isaacs, J.T. J. Natl. Cancer Inst. (1998)
- Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide). Karussis, D.M., Lehmann, D., Slavin, S., Vourka-Karussis, U., Mizrachi-Koll, R., Ovadia, H., Kalland, T., Abramsky, O. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Effects of the immunomodulator LS 2616 on growth and metastasis of the murine B16-F10 melanoma. Kalland, T. Cancer Res. (1986)
- Linomide prevents the lethal effect of anti-Fas antibody and reduces Fas-mediated ceramide production in mouse hepatocytes. Redondo, C., Flores, I., Gonzalez, A., Nagata, S., Carrera, A.C., Merida, I., Martinez-A, C. J. Clin. Invest. (1996)
- Human prostatic cancer cells are sensitive to programmed (apoptotic) death induced by the antiangiogenic agent linomide. Vukanovic, J., Isaacs, J.T. Cancer Res. (1995)
- Successful treatment of autoimmunity in MRL/1 mice with LS-2616, a new immunomodulator. Tarkowski, A., Gunnarsson, K., Nilsson, L.A., Lindholm, L., Stålhandske, T. Arthritis Rheum. (1986)
- Suppression of HIV-1 infection in linomide-treated SCID-hu-PBL mice. del Real, G., Llorente, M., Boscá, L., Hortelano, S., Serrano, A., Lucas, P., Gómez, L., Torán, J.L., Redondo, C., Martínez, C. AIDS (1998)
- Linomide activates the adrenocortical axis in the rat: inhibition of experimental autoimmune encephalomyelitis by linomide is not related to the increase of corticosterone. Weidenfeld, J., Karussis, D., Abramsky, O., Lehmann, D., Arbell, I., Ovadia, H. J. Neuroimmunol. (1997)
- Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue. Zou, L.P., Abbas, N., Volkmann, I., Nennesmo, I., Levi, M., Wahren, B., Winblad, B., Hedlund, G., Zhu, J. Neuropharmacology (2002)
- Antiangiogenic treatment with linomide as chemoprevention for prostate, seminal vesicle, and breast carcinogenesis in rodents. Joseph, I.B., Vukanovic, J., Isaacs, J.T. Cancer Res. (1996)
- Prevention of autoimmune diabetes by linomide in nonobese diabetic (NOD) mice is associated with up-regulation of the TCR-mediated activation of p21(ras). Rapoport, M.J., Weiss, L., Mor, A., Bistritzer, T., Ramot, Y., Slavin, S. J. Immunol. (1996)
- Regulation of natural killer progenitors. Studies with a novel immunomodulator with distinct effects at the precursor level. Kalland, T. J. Immunol. (1990)
- Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers. Vukanovic, J., Isaacs, J.T. Cancer Res. (1995)
- Augmentation of mouse natural killer cell activity by LS 2616, a new immunomodulator. Kalland, T., Alm, G., Stålhandshe, T. J. Immunol. (1985)
- Abolition of the effect of cyclosporine on rat cardiac allograft rejection by the new immunomodulator LS-2616 (Linomide). Wanders, A., Larsson, E., Gerdin, B., Tufveson, G. Transplantation (1989)
- Protective effect of Linomide on TNF-alpha-induced hepatic injury. Klintman, D., Hedlund, G., Thorlacius, H. J. Hepatol. (2002)
- Potentiation of the antiangiogenic ability of linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers. Joseph, I.B., Isaacs, J.T. Cancer Res. (1997)
- Interleukin-10 mediates the protective effect of Linomide by reducing CXC chemokine production in endotoxin-induced liver injury. Li, X., Klintman, D., Sato, T., Hedlund, G., Schramm, R., Jeppsson, B., Thorlacius, H. Br. J. Pharmacol. (2004)
- The novel immunomodulator, Linomide, stimulates interleukin-2-induced human natural killer (NK) cell and PHA-stimulated T cell proliferation from normal donors. Condiotti, R., Slavin, S., Barak, V., Nagler, A. Leuk. Res. (1996)
- Inhibition of acute, experimental autoimmune encephalomyelitis by the synthetic immunomodulator linomide. Karussis, D.M., Lehmann, D., Slavin, S., Vourka-Karussis, U., Mizrachi-Koll, R., Ovadia, H., Ben-Nun, A., Kalland, T., Abramsky, O. Ann. Neurol. (1993)