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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Theilovirus


High impact information on Theilovirus

  • Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors [6].
  • Furthermore, a competition ELISA for TMEV or GC antigen revealed that sera from these infected mice contained antibody(s) with the same specificity as mAb H8 [7].
  • The IRES of a neurovirulent picornavirus, the GDVII strain of Theiler's murine encephalomyelitis virus, requires polypyrimidine tract-binding protein (PTB) for its function [8].
  • Hematopoietic transplant performed after onset of disease resulted in 42% mortality in SJL/J syngeneic transplants, 47% mortality in diseased DBA2 recipients restored with marrow from naive B6D2 donors, and 12% in diseased DBA2 recipients receiving marrow from B6D2 donors previously infected with TMEV [9].
  • CD40L-mediated interactions were also necessary for development of protective H-2b-restricted cytotoxic T cell responses directed against the VP2 region of TMEV as well as for spontaneous remyelination of the spinal cord white matter [10].

Chemical compound and disease context of Theilovirus

  • Treatment of SJL/J mice with TMEV-coupled, ethyl carbodiimide-treated splenocytes either before or after infection with live TMEV prevented the development of clinical disease, including inflammation and demyelination in the CNS [11].
  • A naturally occurring, low pathogenic Theiler's murine encephalomyelitis virus variant showed a single amino acid change within a predominant Th epitope from lysine to arginine at position 244 of VP1 [12].
  • Virus binding was also blocked by wheat germ agglutinin, which specifically binds to sialic acid residues and blocks TMEV binding to whole BHK-21 cells [13].
  • Thus, we demonstrated that the single nucleotide change resulting in an amino acid substitution at position 101 (threonine to isoleucine) of VP-1 determines one aspect of Theiler's virus persistence and disease in mice [14].
  • We report the effect of sialylation on cell surface on entry and the complex structure of DA virus, a persistent TMEV, and the receptor moiety mimic, sialyllactose, refined to a resolution of 3.0 A [15].

Biological context of Theilovirus


Anatomical context of Theilovirus


Gene context of Theilovirus


Analytical, diagnostic and therapeutic context of Theilovirus


  1. Theiler's virus-induced demyelination: prevention by immunosuppression. Lipton, H.L., Dal Canto, M.C. Science (1976) [Pubmed]
  2. Perforin-dependent neurologic injury in a viral model of multiple sclerosis. Murray, P.D., McGavern, D.B., Lin, X., Njenga, M.K., Leibowitz, J., Pease, L.R., Rodriguez, M. J. Neurosci. (1998) [Pubmed]
  3. Viral delivery of an epitope from Haemophilus influenzae induces central nervous system autoimmune disease by molecular mimicry. Croxford, J.L., Anger, H.A., Miller, S.D. J. Immunol. (2005) [Pubmed]
  4. Activity of a newly identified serine protease in CNS demyelination. Scarisbrick, I.A., Blaber, S.I., Lucchinetti, C.F., Genain, C.P., Blaber, M., Rodriguez, M. Brain (2002) [Pubmed]
  5. Characterization of interferon-alpha 13, a novel constitutive murine interferon-alpha subtype. van Pesch, V., Michiels, T. J. Biol. Chem. (2003) [Pubmed]
  6. Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors. Fiette, L., Aubert, C., Müller, U., Huang, S., Aguet, M., Brahic, M., Bureau, J.F. J. Exp. Med. (1995) [Pubmed]
  7. Monoclonal antibody to Theiler's murine encephalomyelitis virus defines a determinant on myelin and oligodendrocytes, and augments demyelination in experimental allergic encephalomyelitis. Yamada, M., Zurbriggen, A., Fujinami, R.S. J. Exp. Med. (1990) [Pubmed]
  8. Cell-specific proteins regulate viral RNA translation and virus-induced disease. Pilipenko, E.V., Viktorova, E.G., Guest, S.T., Agol, V.I., Roos, R.P. EMBO J. (2001) [Pubmed]
  9. Viral hyperinfection of the central nervous system and high mortality after hematopoietic stem cell transplantation for treatment of Theiler's murine encephalomyelitis virus-induced demyelinating disease. Burt, R.K., Padilla, J., Dal Canto, M.C., Miller, S.D. Blood (1999) [Pubmed]
  10. CD40L is critical for protection from demyelinating disease and development of spontaneous remyelination in a mouse model of multiple sclerosis. Drescher, K.M., Zoecklein, L.J., Pavelko, K.D., Rivera-Quinones, C., Hollenbaugh, D., Rodriguez, M. Brain Pathol. (2000) [Pubmed]
  11. Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction. Karpus, W.J., Pope, J.G., Peterson, J.D., Dal Canto, M.C., Miller, S.D. J. Immunol. (1995) [Pubmed]
  12. Preferential induction of IL-10 in APC correlates with a switch from Th1 to Th2 response following infection with a low pathogenic variant of Theiler's virus. Palma, J.P., Yauch, R.L., Kang, H.K., Lee, H.G., Kim, B.S. J. Immunol. (2002) [Pubmed]
  13. Predominant binding of Theiler's viruses to a 34-kilodalton receptor protein on susceptible cell lines. Kilpatrick, D.R., Lipton, H.L. J. Virol. (1991) [Pubmed]
  14. Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection. Zurbriggen, A., Thomas, C., Yamada, M., Roos, R.P., Fujinami, R.S. J. Virol. (1991) [Pubmed]
  15. Sialylation of the host receptor may modulate entry of demyelinating persistent Theiler's virus. Zhou, L., Luo, Y., Wu, Y., Tsao, J., Luo, M. J. Virol. (2000) [Pubmed]
  16. Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection. Rodriguez, M., Zoecklein, L.J., Howe, C.L., Pavelko, K.D., Gamez, J.D., Nakane, S., Papke, L.M. J. Virol. (2003) [Pubmed]
  17. Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses. Pevear, D.C., Calenoff, M., Rozhon, E., Lipton, H.L. J. Virol. (1987) [Pubmed]
  18. Clearance of Theiler's virus infection depends on the ability to generate a CD8+ T cell response against a single immunodominant viral peptide. Mendez-Fernandez, Y.V., Johnson, A.J., Rodriguez, M., Pease, L.R. Eur. J. Immunol. (2003) [Pubmed]
  19. Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP-1 and NF-kappa B. Kwon, D., Fuller, A.C., Palma, J.P., Choi, I.H., Kim, B.S. Glia (2004) [Pubmed]
  20. The scope and activation mechanisms of chemokine gene expression in primary astrocytes following infection with Theiler's virus. Palma, J.P., Kim, B.S. J. Neuroimmunol. (2004) [Pubmed]
  21. Role of natural killer cells as immune effectors in encephalitis and demyelination induced by Theiler's virus. Paya, C.V., Patick, A.K., Leibson, P.J., Rodriguez, M. J. Immunol. (1989) [Pubmed]
  22. Infection with Theiler's murine encephalomyelitis virus directly induces proinflammatory cytokines in primary astrocytes via NF-kappaB activation: potential role for the initiation of demyelinating disease. Palma, J.P., Kwon, D., Clipstone, N.A., Kim, B.S. J. Virol. (2003) [Pubmed]
  23. Split tolerance of Th1 and Th2 cells in tolerance to Theiler's murine encephalomyelitis virus. Peterson, J.D., Karpus, W.J., Clatch, R.J., Miller, S.D. Eur. J. Immunol. (1993) [Pubmed]
  24. Failure of treatment with Linomide or oral myelin tolerization to ameliorate demyelination in a viral model of multiple sclerosis. Drescher, K.M., Rivera-Quinones, C., Lucchinetti, C.F., Rodriguez, M. J. Neuroimmunol. (1998) [Pubmed]
  25. Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. Correa, F., Mestre, L., Docagne, F., Guaza, C. Br. J. Pharmacol. (2005) [Pubmed]
  26. Tmevpg1, a candidate gene for the control of Theiler's virus persistence, could be implicated in the regulation of gamma interferon. Vigneau, S., Rohrlich, P.S., Brahic, M., Bureau, J.F. J. Virol. (2003) [Pubmed]
  27. Induction of chemokine and cytokine genes in astrocytes following infection with Theiler's murine encephalomyelitis virus is mediated by the Toll-like receptor 3. So, E.Y., Kang, M.H., Kim, B.S. Glia (2006) [Pubmed]
  28. Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes. Molina-Holgado, E., Arévalo-Martín, A., Castrillo, A., Boscá, L., Vela, J.M., Guaza, C. J. Neurochem. (2002) [Pubmed]
  29. Membrane lymphotoxin is required for resistance to Theiler's virus infection. Lin, X., Ma, X., Rodriguez, M., Feng, X., Zoecklein, L., Fu, Y.X., Roos, R.P. Int. Immunol. (2003) [Pubmed]
  30. Treatment with bacterial LPS renders genetically resistant C57BL/6 mice susceptible to Theiler's virus-induced demyelinating disease. Pullen, L.C., Park, S.H., Miller, S.D., Dal Canto, M.C., Kim, B.S. J. Immunol. (1995) [Pubmed]
  31. Lack of cross-reaction between myelin basic proteins and putative demyelinating virus envelope proteins. Rubio, N., Cuesta, A. Mol. Immunol. (1989) [Pubmed]
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