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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Glottis


High impact information on Glottis

  • We calculated Qaw using the time-dependent decrease in DME concentration in relation to the helium concentration in an expired volume fraction between 80 and 130 ml (representing an anatomic dead-space segment distal to the glottis) and the mean DME concentration [3].
  • A fiberoptic bronchoscope positioned in the airway photographed the glottis before induction of anesthesia A second photograph was obtained after induction with 3 microg/kg sufentanil administered during a period of 2 min [4].
  • The endocrine cells, which were immunoreactive for protein gene product 9.5 (PGP 9.5) and calcitonin gene-related peptide (CGRP), were observed within the epithelial layer of the laryngeal cavity and in the laryngeal gland, while solitary endocrine cells with apical and/or basal cytoplasmic processes appeared near the glottis [5].
  • The structure of the nervous network and the distribution of tyrosine hydroxylase (TH)- and various neuropeptide-containing nerves were immunohistochemically studied in the glottis of the dog [6].
  • In the subepithelial layer of the posterior glottis, a moderate number of galanin (GAL)-immunoreactive nerve fibers were observed, while only a few fibers were present in the anterior glottis [6].

Biological context of Glottis


Anatomical context of Glottis

  • It is concluded that the site of the cause of inability to maintain bag-and-mask ventilation after fentanyl lies above the trachea, specifically at the glottis [8].
  • We advanced a 3.1-mm pediatric fibreoptic bronchoscope (FOB) through an orally inserted nasopharyngeal airway to identify the glottis and sprayed 0.5% lidocaine onto the airway mucosa [9].

Associations of Glottis with chemical compounds

  • Adding CO2 to the inspired gas led to partial widening of the glottis in two of three subjects [10].
  • Benzocaine-based anesthetic sprays are commonly used in sheep to anesthetize the nasal passages and glottis before intubation [11].
  • Thus, as in the diaphragm and thyroarytenoideus muscles, onset time and duration of succinylcholine or vecuronium blockade were shorter in the abductor muscle of the glottis, cricoarytenoideus dorsalis, than in the limb muscle [12].
  • Any movement of the injected O2 to the alveoli through an open glottis probably resulted from simple diffusion as well as from agitation and mixing of gases by simulated respiratory activity [13].
  • Both inspiratory and expiratory glottis width decreased after histamine had been inhaled (dose range 2.4-9.6 mg) or injected intravenously (dose of 4 micrograms/kg), being associated with a reduction in forced expired volume in 1.0 s [14].

Gene context of Glottis

  • Twenty-five patients with severe squamous intraepithelial neoplasia, grade 3 (SIN III) of the glottis were identified and followed up; three patients (12%) eventually developed invasive carcinoma and nine patients (36%) were noted to have coexisting microinvasive carcinoma [15].
  • The integrated peak V activity (I-ENGv) showed a linear relationship to OBP (r = 0.944) in the glottis occluded frog, but a curvilinear relationship to peak buccal pressure (peak BP) in the spontaneously breathing frog during inflation period [16].
  • The regurgitation of a bolus started with a contraction of cranial compartment 1 (C 1) during a B-sequence, followed by a deep inspiration with closed glottis [17].
  • In a patient with the Treacher-Collins syndrome in whom conventional laryngoscopy had proved impossible and tracheal intubation extremely difficult, this manoeuvre exposed the entire glottis and made tracheal intubation under direct vision easy [18].
  • In all T2 cancers of the glottis and subglottis (n = 36), a total resection was possible [19].


  1. Lansoprazole and glottis edema. Pérez Roldán, F., de los Ríos, I.L., Rodríguez Quinzaños, E. Am. J. Gastroenterol. (1999) [Pubmed]
  2. Predictors of thyroid gland invasion in glottic squamous cell carcinoma. Sparano, A., Chernock, R., Laccourreye, O., Weinstein, G., Feldman, M. Laryngoscope (2005) [Pubmed]
  3. Airway mucosal blood flow in humans. Response to adrenergic agonists. Onorato, D.J., Demirozu, M.C., Breitenbücher, A., Atkins, N.D., Chediak, A.D., Wanner, A. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  4. Difficult or impossible ventilation after sufentanil-induced anesthesia is caused primarily by vocal cord closure. Bennett, J.A., Abrams, J.T., Van Riper, D.F., Horrow, J.C. Anesthesiology (1997) [Pubmed]
  5. Laryngeal endocrine cells: topographic distribution and adaptation to chronic hypercapnic hypoxia. Yamamoto, Y., Kusakabe, T., Hayashida, Y., Yoshida, T., Matsuda, H., Atoji, Y., Suzuki, Y. Histochem. Cell Biol. (2000) [Pubmed]
  6. Neurochemical markers in the nervous plexus of the canine glottis. Yamamoto, Y., Atoji, Y., Suzuki, Y. J. Auton. Nerv. Syst. (1998) [Pubmed]
  7. Respiratory neuromuscular output during breath holding. Whitelaw, W.A., McBride, B., Amar, J., Corbet, K. Journal of applied physiology: respiratory, environmental and exercise physiology. (1981) [Pubmed]
  8. Fentanyl-O2-N2O rigidity and pulmonary compliance. Scamman, F.L. Anesth. Analg. (1983) [Pubmed]
  9. Innovative airway management for peritonsillar abscess. Beriault, M., Green, J., Hui, A. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2006) [Pubmed]
  10. Effects of nasal positive-pressure hyperventilation on the glottis in normal awake subjects. Jounieaux, V., Aubert, G., Dury, M., Delguste, P., Rodenstein, D.O. J. Appl. Physiol. (1995) [Pubmed]
  11. Methemoglobinemia induced by a benzocaine-based topically administered anesthetic in eight sheep. Lagutchik, M.S., Mundie, T.G., Martin, D.G. J. Am. Vet. Med. Assoc. (1992) [Pubmed]
  12. Succinylcholine and vecuronium blockade of the diaphragm, laryngeal and limb muscles in the anaesthetized goat. Ibebunjo, C., Hall, L.W. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1994) [Pubmed]
  13. Apnoeic diving safety--experimental approaches to oxygen augmentation. Smit, P.J., Lessing, A.J., Steyn, E.S., Daehne, H.O. S. Afr. Med. J. (1984) [Pubmed]
  14. Narrowing of glottis opening in humans associated with experimentally induced bronchoconstriction. Higenbottam, T. Journal of applied physiology: respiratory, environmental and exercise physiology. (1980) [Pubmed]
  15. Carcinoma in situ and microinvasive squamous carcinoma of the laryngeal glottis. Crissman, J.D., Zarbo, R.J., Drozdowicz, S., Jacobs, J., Ahmad, K., Weaver, A. Arch. Otolaryngol. Head Neck Surg. (1988) [Pubmed]
  16. Trigeminal nerve activity and buccal pressure as an index of total inspiratory activity in the bullfrog. Sakakibara, Y. Jpn. J. Physiol. (1984) [Pubmed]
  17. Chewing activities and oesophageal motility during feed intake, rumination and eructation in camels. von Engelhardt, W., Haarmeyer, P., Kaske, M., Lechner-Doll, M. J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. (2006) [Pubmed]
  18. Difficult laryngoscopy made easy with a "BURP". Knill, R.L. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1993) [Pubmed]
  19. Laser surgery for the treatment of larynx carcinomas: indications, techniques, and preliminary results. Eckel, H.E., Thumfart, W.F. The Annals of otology, rhinology, and laryngology. (1992) [Pubmed]
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