Disease relevance of Cross Circulation

• Galactosamine induced hepatic failure rats were treated by whole blood and plasma cross circulation [1].
• This technique of cross circulation was then used in a total of 45 children during the next 16 months to successfully repair tetralogy of Fallot, atrioventricular canal, and ventricular septal defect [2].

High impact information on Cross Circulation

• Competition was demonstrated by cross-circulation of normal and cholesterol-fed or normal and WHHL rabbits, in which the rapid influx of plasma containing the accumulated plasma lipoproteins from cholesterol-fed or WHHL rabbits was shown to impair the uptake of chylomicrons by the liver and bone marrow of normal rabbits [3].
• Cross-circulation between adrenalectomized and nephrectomized rats for 15 or 30 minutes, dramatically lowered prorenin and raised renin levels in both types of rats, suggesting extensive activation of prorenin to renin [4].
• Similar cross-circulation experiments between pairs of normal rabbits did not alter the pressor responses to NE [5].
• Administration of this AII antagonist to the normal rabbits prevented them from showing pressor hyperresponsiveness following the cross-circulation of blood [6].
• CONCLUSION: The hDAF transgenic porcine liver reduced complement activation in xenoperfusion with healthy nonhuman primate blood and led to extended duration of cross-circulation [7].

Biological context of Cross Circulation

• We examined the role of endothelium-derived relaxing factor (EDRF) in lidocaine-induced pulmonary vasoconstriction in experiments using the nitric oxide synthase inhibitor NG-nitro-L-arginine (L-NNA) and EDRF precursor L-arginine in a canine cross-circulation model [8].

Associations of Cross Circulation with chemical compounds

• C1 appears to possess relaxin bioactivity since the frequency of intrauterine pressure cycles in nonpregnant rats declined during cross-circulation with day 15 pregnant rats [9].
• A final experiment examined pressor responses to NE in six normal rabbits before and after cross circulation of blood with six DOCA-salt rabbits [10].
• Proceedings: Cross-circulation experiments in dogs discerning the target organ of carbon monoxide intoxication [11].
• 1. The effect of compound 48/80 on the rat femoral vasculature was examined by means of a cross-circulation technique [12].
• After cross-circulation the ASA-treated animals were still unable to generate TXB in response to ZAP infusion [13].

Gene context of Cross Circulation

• The effects of centrally administered thyrotropin-releasing hormone (TRH) on vagal efferent and cortical electroencephalographic (EEG) activity were assessed in rat brains which were functionally isolated from the body trunk and maintained via cross-circulation [14].
• Cross circulation for hepatic coma [15].
• Parabiosis experiments suggest that ob/ob mice are deficient in a circulating "lipostatic" signal but respond to such a signal when it is delivered in the cross circulation from their parabiotic partner [16].

Analytical, diagnostic and therapeutic context of Cross Circulation

• The effects of cross-circulation and charcoal hemoperfusion on adenylate energy charge of the remnant liver after major hepatic resection [17].

References