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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Parabiosis


High impact information on Parabiosis

  • In additional studies, animals were exposed to granulocyte-colony-stimulating factor (G-CSF) and stem cell factor at days 17 to 20 of parabiosis and were studied 3 weeks later; 10.1% of marrow HSCs derived from the parabiotic partner [3].
  • Parabiosis with a castrate male partner did not appear to alter the process significantly, but surgical cryptorchidy, even when combined with parabiosis, completely prevented the development of this pretumorous lesion as did the chronic administration of diethylstilbestrol [4].
  • Therefore, mice primed with either SRBC or LPS 6 months previously and nonprimed mice were joined for parabiosis [5].
  • The transfer of tolerance to DNCB-contact sensitivity in guinea pigs by parabiosis [6].
  • In summary, parabiosis of normal mice to Hyp mice resulted in the development of phosphaturia and decreased BBMV phosphate transport in the normal mice [7].

Biological context of Parabiosis


Associations of Parabiosis with chemical compounds

  • The onset of repression of a known innervation-dependent acetylcholine receptor mRNA did not coincide with the initiation of troponin T iso-mRNA switching and was not affected by parabiosis [10].
  • Experimental pairs, consisting of a normal rat and a distal 50% small bowel excluded partner, demonstrated significantly increased combined hepatic cholesterol synthesis when compared to control pairs, consisting of two normal rats, both at 3 and 5 days following parabiosis [11].
  • The serum cholesterol level and the biliary and fecal CA/CDCA ratios in old rats were higher than those in young rats but decreased after parabiosis with young rats, although they were still higher than those in young rats [2].
  • The optical and electron microscopy, including histochemistry, of costal cartilage of these rats has been compared with that in single cortisone treated rats, single controls, and control parabiosed with control rats, at 14 and 28 days after parabiosis [12].
  • The unresponsiveness induced by immunosuppressive treatment has not been reversed by an additional treatment with the high dose of cyclophosphamide known to reverse hapten-induced tolerance, and has not been transferred by parabiosis from tolerant to normal partners [13].

Gene context of Parabiosis

  • Suppression and reversal of gld disease by parabiosis with normal mice [8].
  • Further, parabiosis of Rsl and rsl mice does not alter expression patterns, consistent with rsl action being liver intrinsic [14].
  • Notably, heterochronic parabiosis restored the activation of Notch signalling as well as the proliferation and regenerative capacity of aged satellite cells [15].
  • Parabiosis between wild-type and heterozygous klotho mice results in restoration of endothelial function in heterozygous klotho mice [16].
  • We have previously shown that mice heterozygous for a defect in the klotho gene upon parabiosis with wild-type mice show improved endothelial function, suggesting that the klotho gene product protects against endothelial dysfunction [17].


  1. Failure of pancreatic polypeptide release in congenitally obese mice. Jia, B.Q., Taylor, I.L. Gastroenterology (1984) [Pubmed]
  2. Bile acid metabolism in young-old parabiotic rats. Uchida, K., Takase, H., Nomura, Y., Satoh, T., Igimi, H., Takeuchi, N. Lipids (1997) [Pubmed]
  3. Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure. Abkowitz, J.L., Robinson, A.E., Kale, S., Long, M.W., Chen, J. Blood (2003) [Pubmed]
  4. Effects of cryptorchidy, parabiosis, and estrogen administration upon Leydig cell tumorigenesis in Fischer rats. Huseby, R.A. Cancer Res. (1981) [Pubmed]
  5. B memory cells in the thymus: part of the pool of potentially circulating memory cells. Benner, R., van Oudenaren, A., de Ruiter, H. J. Immunol. (1977) [Pubmed]
  6. The transfer of tolerance to DNCB-contact sensitivity in guinea pigs by parabiosis. Polak, L. J. Immunol. (1975) [Pubmed]
  7. The renal phosphate transport defect in normal mice parabiosed to X-linked hypophosphatemic mice persists after parathyroidectomy. Meyer, R.A., Tenenhouse, H.S., Meyer, M.H., Klugerman, A.H. J. Bone Miner. Res. (1989) [Pubmed]
  8. Suppression and reversal of gld disease by parabiosis with normal mice. Kakkanaiah, V.N., MacDonald, G.C., Cohen, P.L., Eisenberg, R.A. Clin. Immunol. Immunopathol. (1996) [Pubmed]
  9. When did leptin become a reproductive hormone? Castracane, V.D., Henson, M.C. Seminars in reproductive medicine. (2002) [Pubmed]
  10. Troponin T gene switching is developmentally regulated by plasma-borne factors in parabiotic chicks. Wong, T.S., Ordahl, C.P. Dev. Biol. (1996) [Pubmed]
  11. Increased hepatic cholesterol synthesis in normal rats by cross-circulation with ileal bypassed partners. Schneider, P.D., Guzman, I.J., Rucker, R.D., Stocks, T.G., Varco, R.L., Buchwald, H. Atherosclerosis (1979) [Pubmed]
  12. Cortisone induced alterations of costal cartilage in single and in parabiosed rats. Dearden, L.C., Mosier, H.D., Espinosa, T. Cell Tissue Res. (1978) [Pubmed]
  13. Mechanism of tolerance to DNCB-contact sensitivity induced by immunosuppressive agents. Polak, L., Rinck, C. Allergologia et immunopathologia. (1978) [Pubmed]
  14. The regulator of sex-limitation gene, rsl, enforces male-specific liver gene expression by negative regulation. Tullis, K.M., Krebs, C.J., Leung, J.Y., Robins, D.M. Endocrinology (2003) [Pubmed]
  15. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Conboy, I.M., Conboy, M.J., Wagers, A.J., Girma, E.R., Weissman, I.L., Rando, T.A. Nature (2005) [Pubmed]
  16. Klotho protein protects against endothelial dysfunction. Saito, Y., Yamagishi, T., Nakamura, T., Ohyama, Y., Aizawa, H., Suga, T., Matsumura, Y., Masuda, H., Kurabayashi, M., Kuro-o, M., Nabeshima, Y., Nagai, R. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  17. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Saito, Y., Nakamura, T., Ohyama, Y., Suzuki, T., Iida, A., Shiraki-Iida, T., Kuro-o, M., Nabeshima, Y., Kurabayashi, M., Nagai, R. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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